arrow

From NeuroLex

Jump to: navigation, search



Methantheline

Name: Methantheline
Description: Methantheline is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children). Pharmacology: Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites. Mechanism of action: Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. Drug type: Approved. Small Molecule. Drug category: Anticholinergic Agents. Antispasmodics
Synonym(s): Banthine Bromide, MTB 51, Methantheline Bromide, Methanthelinium, Methanthelinium Bromide, Methanthelinum, Methanthine Bromide, Asabaine, Avagal, Banthin, Banthine, Dixamone Bromide, Doladene, Frenogastrico, Gastrin I, Gastrin-1 Human, Gastron, Gastrosedan, Mantheline, Metantyl, Metaxan, Methanide, Methelina, Resobantin, Ulcine, Ulcudexter, Vagamin, Vagantin, Xanteline
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00940
Id: DB00940
Related to: Cholinergic system, Muscarinic acetylcholine receptor M1
Link to OWL / RDF: Download this content as OWL/RDF


Contributors

Ayeliset, Ccdbuser, Nifbot2



bookmark
Facts about MethanthelineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00940  +
DefinitionMethantheline is a synthetic antispasmodic Methantheline is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children). Pharmacology: Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites. Mechanism of action: Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. Drug type: Approved. Small Molecule. Drug category: Anticholinergic Agents. Antispasmodics ry: Anticholinergic Agents. Antispasmodics
Has roleDrug  +
IdDB00940  +
LabelMethantheline  +
ModifiedDate14 April 2014  +
RelatedToCholinergic system  +, and Muscarinic acetylcholine receptor M1  +
SuperCategoryMolecular entity  +
SynonymBanthine Bromide  +, MTB 51  +, Methantheline Bromide  +, Methanthelinium  +, Methanthelinium Bromide  +, Methanthelinum  +, Methanthine Bromide  +, Asabaine  +, Avagal  +, Banthin  +, Banthine  +, Dixamone Bromide  +, Doladene  +, Frenogastrico  +, Gastrin I  +, Gastrin-1 Human  +, Gastron  +, Gastrosedan  +, Mantheline  +, Metantyl  +, Metaxan  +, Methanide  +, Methelina  +, Resobantin  +, Ulcine  +, Ulcudexter  +, Vagamin  +, Vagantin  +, and Xanteline  +