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Moclobemide

Name: Moclobemide
Description: A reversible inhibitor of monoamine oxidase type A; (RIMA); (see monoamine oxidase inhibitors) that has antidepressive properties. (PubChem) Pharmacology: Moclobemide belongs to a class of MAOI antidepressants known as reversible inhibitors of monoamine oxidase type-A (RIMAs). The primary role of monoamine oxidase MAO lies in the metabolism of and regulation of the levels of monoamines (serotonin, norepinephrine, and dopamine). Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms. RIMAs demonstrate transient inhibition of the substrate binding site of MAO-A as well as competitive displacement from this site by bioamines. The RIMAs are distinguished from the older monoamine oxidase inhibitors (MAOIs) by their selectivity and reversibility. Mechanism of action: The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of monoamines in the neurotransmitters. This results in an increase in the monoamines, relieving depressive symptoms. Drug type: Approved. Investigational. Small Molecule. Drug category: Antidepressive Agents. Monoamine Oxidase Inhibitors
Synonym(s): 4-Chlor-N-(2-morpholinoethyl)benzamid, 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide, 4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide, Moclaime, Moclamide, Moclamine, Moclobemid, Moclobemida (INN-Spanish), Moclobemide (Usan:Ban:Inn), Moclobemidum (INN-Latin), moclobemide, p-Chloro-N-(2-morpholinoethyl)benzamide, Aurorix, Manerix
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01171
*Id: DB01171
Related to: Amine oxidase (flavin-containing) A
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Facts about MoclobemideRDF feed
Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01171  +
DefinitionA reversible inhibitor of monoamine oxidas A reversible inhibitor of monoamine oxidase type A; (RIMA); (see monoamine oxidase inhibitors) that has antidepressive properties. (PubChem) Pharmacology: Moclobemide belongs to a class of MAOI antidepressants known as reversible inhibitors of monoamine oxidase type-A (RIMAs). The primary role of monoamine oxidase MAO lies in the metabolism of and regulation of the levels of monoamines (serotonin, norepinephrine, and dopamine). Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms. RIMAs demonstrate transient inhibition of the substrate binding site of MAO-A as well as competitive displacement from this site by bioamines. The RIMAs are distinguished from the older monoamine oxidase inhibitors (MAOIs) by their selectivity and reversibility. Mechanism of action: The mechanism of action of moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of monoamines in the neurotransmitters. This results in an increase in the monoamines, relieving depressive symptoms. Drug type: Approved. Investigational. Small Molecule. Drug category: Antidepressive Agents. Monoamine Oxidase Inhibitors ssive Agents. Monoamine Oxidase Inhibitors
Has roleDrug  +
IdDB01171  +
LabelMoclobemide  +
ModifiedDate14 April 2014  +
RelatedToAmine oxidase (flavin-containing) A  +
SuperCategoryMolecular entity  +
Synonym4-Chlor-N-(2-morpholinoethyl)benzamid  +, 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide  +, 4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide  +, Moclaime  +, Moclamide  +, Moclamine  +, Moclobemid  +, Moclobemida (INN-Spanish)  +, Moclobemide (Usan:Ban:Inn)  +, Moclobemidum (INN-Latin)  +, moclobemide  +, p-Chloro-N-(2-morpholinoethyl)benzamide  +, Aurorix  +, and Manerix  +