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Naloxone

Name: Naloxone
Description: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. (PubChem) Pharmacology: Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity. Mechanism of action: While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor. Drug type: Approved. Small Molecule. Drug category: Antinarcotic Agents. Depressants. Narcotic Antagonists. Opiate Antagonists
Synonym(s): EN 1530 Base, L-Naloxone, N-Allylnoroxymorphone, Nalossone (Dcit), Naloxona (INN-Spanish), Naloxone HCl, Naloxonum (INN-Latin), Nalone, Narcan, Narcanti, Narcon
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01183
Id: CHEBI_7459
Related to: Estrogen receptor, Delta-type opioid receptor, Mu-type opioid receptor, cAMP response element-binding protein
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Aarnaud, Bandrow, Ccdbuser, Nifbot2



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Facts about NaloxoneRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01183  +
DefinitionA specific opiate antagonist that has no a A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. (PubChem) Pharmacology: Naloxone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity. Mechanism of action: While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor. Drug type: Approved. Small Molecule. Drug category: Antinarcotic Agents. Depressants. Narcotic Antagonists. Opiate Antagonists . Narcotic Antagonists. Opiate Antagonists
Has roleDrug  +
IdCHEBI_7459  +
LabelNaloxone  +
ModifiedDate14 April 2014  +
RelatedToEstrogen receptor  +, Delta-type opioid receptor  +, Mu-type opioid receptor  +, and CAMP response element-binding protein  +
SuperCategoryMolecular entity  +
SynonymEN 1530 Base  +, L-Naloxone  +, N-Allylnoroxymorphone  +, Nalossone (Dcit)  +, Naloxona (INN-Spanish)  +, Naloxone HCl  +, Naloxonum (INN-Latin)  +, Nalone  +, Narcan  +, Narcanti  +, and Narcon  +