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Nateglinide

Name: Nateglinide
Description: Nateglinide is an amino-acid derivative that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. Pharmacology: Nateglinide is an amino-acid derivative that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. Mechanism of action: Nateglinide interacts with the ATP-sensitive potassium (K+ATP) channel on pancreatic beta-cells. The subsequent depolarization of the beta cell opens the calcium channel, producing calcium influx and insulin secretion. The extent of insulin release is glucose dependent and diminishes at low glucose levels. Nateglinide is highly tissue selective with low affinity for heart and skeletal muscle. Drug type: Approved. Investigational. Small Molecule. Drug category: Hypoglycemic Agents. Meglitinides
Synonym(s): Nateglinide (INN), SDZ-DJN 608, nateglinide, Fastic, Starlix, Starsis
Related to: ATP-binding cassette transporter sub-family C member 8, ATP-sensitive inward rectifier potassium channel 1, ATP-sensitive inward rectifier potassium channel 11
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00731
Id: DB00731
Link to OWL / RDF: Download this content as OWL/RDF


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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00731  +
DefinitionNateglinide is an amino-acid derivative th Nateglinide is an amino-acid derivative that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. Pharmacology: Nateglinide is an amino-acid derivative that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. Mechanism of action: Nateglinide interacts with the ATP-sensitive potassium (K+ATP) channel on pancreatic beta-cells. The subsequent depolarization of the beta cell opens the calcium channel, producing calcium influx and insulin secretion. The extent of insulin release is glucose dependent and diminishes at low glucose levels. Nateglinide is highly tissue selective with low affinity for heart and skeletal muscle. Drug type: Approved. Investigational. Small Molecule. Drug category: Hypoglycemic Agents. Meglitinides ategory: Hypoglycemic Agents. Meglitinides
Has roleDrug  +
IdDB00731  +
LabelNateglinide  +
ModifiedDate14 April 2014  +
RelatedToATP-binding cassette transporter sub-family C member 8  +, ATP-sensitive inward rectifier potassium channel 1  +, and ATP-sensitive inward rectifier potassium channel 11  +
SuperCategoryMolecular entity  +
SynonymNateglinide (INN)  +, SDZ-DJN 608  +, nateglinide  +, Fastic  +, Starlix  +, and Starsis  +