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Neostigmine

Name: Neostigmine
Description: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. (PubChem) Pharmacology: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Mechanism of action: Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Parasympathomimetics
Synonym(s): Neostigmine omega, Prostigmin
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01400
*Id: CHEBI:7514
Related to: Acetylcholinesterase
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Contributors

Bandrow, Ccdbuser, Nifbot2, Whetzel



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about NeostigmineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01400  +
DefinitionA cholinesterase inhibitor used in the tre A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. (PubChem) Pharmacology: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Mechanism of action: Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Parasympathomimetics nesterase Inhibitors. Parasympathomimetics
Has roleDrug  +
IdCHEBI:7514  +
LabelNeostigmine  +
ModifiedDate31 July 2014  +
RelatedToAcetylcholinesterase  +
SuperCategoryMolecular entity  +
SynonymNeostigmine omega  +, and Prostigmin  +