EditFrom NeuroLex
Neostigmine
| Name: | Neostigmine |
| Description: | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. (PubChem) Pharmacology: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Mechanism of action: Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Parasympathomimetics |
| Synonym(s): | Neostigmine omega, Prostigmin |
| Related to: | Acetylcholinesterase |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB01400 |
| Id: | CHEBI: 7514 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about NeostigmineRDF feed
| Comment | taken from DrugBank |
| CurationStatus | uncurated + |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB01400 + |
| Definition | A cholinesterase inhibitor used in the tre … A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. (PubChem) Pharmacology: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Mechanism of action: Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Parasympathomimetics nesterase Inhibitors. Parasympathomimetics |
| Has role | Drug + |
| Id | CHEBI: 7514 + |
| Label | Neostigmine + |
| ModifiedDate | 16 March 2010 + |
| RelatedTo | Acetylcholinesterase + |
| SuperCategory | Molecule + |
| Synonym | Neostigmine omega +, and Prostigmin + |