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Neostigmine

Name: Neostigmine
Description: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. (PubChem) Pharmacology: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Mechanism of action: Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Parasympathomimetics
Synonym(s): Neostigmine omega, Prostigmin
Related to: Acetylcholinesterase
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01400
Id: CHEBI: 7514
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01400  +
DefinitionA cholinesterase inhibitor used in the tre A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. (PubChem) Pharmacology: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Mechanism of action: Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Parasympathomimetics nesterase Inhibitors. Parasympathomimetics
Has roleDrug  +
IdCHEBI: 7514  +
LabelNeostigmine  +
ModifiedDate14 April 2014  +
RelatedToAcetylcholinesterase  +
SuperCategoryMolecular entity  +
SynonymNeostigmine omega  +, and Prostigmin  +