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Neostriatum direct pathway spiny neuron

Name: Neostriatum direct pathway spiny neuron
Description: The principal projection neuron of the caudate and putamen.[1]
Synonym(s): Medium spiny neuron, Neostriatal spiny neuron, Medium-sized spiny neuron, Striatal spiny neuron, Striatal medium spiny neuron
Abbreviation: MSN
Has role: Principal neuron role
Super-category: Neuron
URL: Kemp and Powell,
Id: nlx_149135
Organism: Mammal
Link to OWL / RDF: Download this content as OWL/RDF

Soma Specific Properties

Cell Soma Shape: Multipolar
Cell Soma Size: Medium soma
Soma Location: Caudate nucleus, Putamen, Nucleus accumbens

Dendrite Specific Properties

Spine density on dendrites: spiny high density

Axon Specific Properties

Axon myelination: myelinated
Axon projection laterality: ipsilateral
Origin of axon: soma and sometimes dendrite
Location of distant axon arborization: Globus pallidus internal segment, Globus pallidus external segment, Substantia nigra
Location of local axon arborization: Striosomal compartment of neostriatum, Matrix compartment of neostriatum

Intrinsic Properties

Neurotransmitter released: GABA
Neurotransmitter receptors: D1 receptor, AMPA-type glutamate-gated cationic channel, D2 receptor
Molecular constituents: Enkephalin, Substance P


  1. Wilson CJ & Groves PM (1980) Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: a study employing intracellular inject of horseradish peroxidase. J Comp Neurol 194: 599-615 PubMed


This page uses this default form:Petilla_neuron



Facts about Neostriatum direct pathway spiny neuronRDF feed
AbbrevMSN  +
AxonMyelinationmyelinated  +
AxonProjectionLateralityipsilateral  +
CellSomaShapeCategory:Multipolar   +
CellSomaSizeMedium soma  +
CommentThis class is duplicated in NIF
CurationStatusuncurated  +
DefiningCitationKemp JM and Powell TPS. The structure of the caudate nucleus of the cat: light and electron microscopy. Proc. R. Soc. Lond B 262:383-401  +
DefinitionThe principal projection neuron of the caudate and putamen.
DendriteThickness2-3 um  +
Has default formThis property is a special property in this wiki.Petilla neuron  +
Has rolePrincipal neuron role  +
Idnlx_149135  +
LabelNeostriatum direct pathway spiny neuron  +
Located inCaudate nucleus  +, Putamen  +, and Nucleus accumbens  +
LocationOfAxonArborizationGlobus pallidus internal segment  +, Globus pallidus external segment  +, and Substantia nigra  +
LocationOfLocalAxonArborizationStriosomal compartment of neostriatum  +, and Matrix compartment of neostriatum  +
ModifiedDate1 November 2012  +
MolecularConstituentsEnkephalin  +, and Substance P  +
NeurotransmitterGABA  +
NeurotransmitterReceptorsD1 receptor  +, AMPA-type glutamate-gated cationic channel  +, D2 receptor  +, and Muscarinic ACh  +
NumberOfPrimaryDendrites3-5  +
OriginOfAxonsoma and sometimes dendrite  +
Page has default formThis property is a special property in this wiki.Petilla neuron  +
SpeciesMammal  +
SpineDensityOnDendritesSpiny high density  +
SuperCategoryNeuron  +
SynonymMedium spiny neuron  +, Neostriatal spiny neuron  +, Medium-sized spiny neuron  +, Striatal spiny neuron  +, and Striatal medium spiny neuron  +