Neuronal nuclear antigen

Current revision (unreviewed)

Name:	Neuronal nuclear antigen
Description:	A 46/48KD DNA-binding, neuron-specific protein found in nuclei which is present in most vertebrate CNS and PNS neuronal cell types. NeuN is widely used to label neurons, despite some shortcomings. A few neuronal cell types are not recognized by the NeuN antibody, such as cerebellar Purkinje cells and Golgi cells, olfactory Mitral cells and retinal photoreceptors. However the vast majority of neurons are strongly NeuN positive. NeuN immunoreactivity becomes obvious as neurons mature, typically after they have downregulated expression of Doublecortin, a marker seen in the earliest stages of neuronal development. (Adapted from Wikipedia: http://en.wikipedia.org/wiki/NeuN)
Synonym(s):	Feminizing Locus on X-3, Fox-3, or Hexaribonucleotide Binding Protein-3
Has role:	Neuron specific marker
Abbreviation:	NeuN, Neuna60
Super-category:	Protein
Id:	nlx_152221
Link to OWL / RDF:	Download this content as OWL/RDF

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Abbrev	NeuN, Neuna60 +
CurationStatus	uncurated +
Definition	A 46/48KD DNA-binding, neuron-specific pro … A 46/48KD DNA-binding, neuron-specific protein found in nuclei which is present in most vertebrate CNS and PNS neuronal cell types. NeuN is widely used to label neurons, despite some shortcomings. A few neuronal cell types are not recognized by the NeuN antibody, such as cerebellar Purkinje cells and Golgi cells, olfactory Mitral cells and retinal photoreceptors. However the vast majority of neurons are strongly NeuN positive. NeuN immunoreactivity becomes obvious as neurons mature, typically after they have downregulated expression of Doublecortin, a marker seen in the earliest stages of neuronal development. (Adapted from Wikipedia: http://en.wikipedia.org/wiki/NeuN) pedia: http://en.wikipedia.org/wiki/NeuN)
Has role	Neuron specific marker +
Id	nlx_152221 +
Label	Neuronal nuclear antigen +
ModifiedDate	15 April 2013 +
SuperCategory	Protein +
Synonym	Feminizing Locus on X-3 +, Fox-3 +, and or Hexaribonucleotide Binding Protein-3 +