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Norepinephrine

Name: Norepinephrine
Description: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. (PubChem) Pharmacology: Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance. Mechanism of action: Norepinephrine functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Drug type: Approved. Small Molecule. Drug category: Adrenergic alpha-Agonists. Sympathomimetics. Vasoconstrictor Agents
Synonym(s): Arterenol, L-Norepinephrine, L-noradrenaline, Noradrenaline, Norepinephrine, Levophed
Abbreviation: NE
Is part of: Catecholamine system, Adrenergic system, Noradrenergic system
Has role: Drug, Neurotransmitter, Hormone
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00368
Id: DB00368
Related to: Beta-1 adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2C adrenergic receptor, Sodium-dependent noradrenaline transporter, Alpha-1A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-1B adrenergic receptor, Beta-2 adrenergic receptor, Alpha-1D adrenergic receptor, Phenylalanine-4-hydroxylase, Beta-3 adrenergic receptor
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Categories related to Norepinephrine

Adrenoceptor receptor, Alpha2A receptor, Alpha2B receptor, Alpha2C receptor, Alpha2D receptor, Beta1 receptor, Beta2 receptor, Beta3 receptor, Dopamine beta-hydroxylase, Phenylethanolamine N-Methyltransferase, S-Adenosylmethionine

Neurons that have Norepinephrine as their neurotransmitter

Locus coeruleus NA neuron, Taste bud type 3 cell




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Facts about NorepinephrineRDF feed
AbbrevNE  +
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00368  +
DefinitionPrecursor of epinephrine that is secreted Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. (PubChem) Pharmacology: Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance. Mechanism of action: Norepinephrine functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Drug type: Approved. Small Molecule. Drug category: Adrenergic alpha-Agonists. Sympathomimetics. Vasoconstrictor Agents . Sympathomimetics. Vasoconstrictor Agents
Has roleDrug  +, Neurotransmitter  +, and Hormone  +
IdDB00368  +
Is part ofCatecholamine system  +, Adrenergic system  +, and Noradrenergic system  +
LabelNorepinephrine  +
ModifiedDate14 April 2014  +
RelatedToBeta1 receptor  +, Alpha2A receptor  +, Alpha2C receptor  +, Sodium-dependent noradrenaline transporter  +, Alpha1A receptor  +, Alpha2B receptor  +, Alpha1B receptor  +, Beta2 receptor  +, Alpha1D receptor  +, Phenylalanine-4-hydroxylase  +, and Beta3 receptor  +
SuperCategoryMolecular entity  +
SynonymArterenol  +, L-Norepinephrine  +, L-noradrenaline  +, Noradrenaline  +, Norepinephrine  +, and Levophed  +