EditFrom NeuroLex
Norepinephrine
| Name: | Norepinephrine |
| Description: | Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. (PubChem) Pharmacology: Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance. Mechanism of action: Norepinephrine functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Drug type: Approved. Small Molecule. Drug category: Adrenergic alpha-Agonists. Sympathomimetics. Vasoconstrictor Agents |
| Synonym(s): | Arterenol, L-Norepinephrine, L-noradrenaline, Noradrenaline, Norepinephrine, Levophed |
| Is part of: | Catecholamine system, Adrenergic system, Noradrenergic system |
| Related to: | Beta-1 adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2C adrenergic receptor, Sodium-dependent noradrenaline transporter, Alpha-1A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-1B adrenergic receptor, Beta-2 adrenergic receptor, Alpha-1D adrenergic receptor, Phenylalanine-4-hydroxylase, Beta-3 adrenergic receptor |
| Has role: | Drug, Neurotransmitter, Hormone |
| Abbreviation: | NE |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00368 |
| Id: | DB00368 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Categories related to Norepinephrine
Adrenoceptor receptor, Alpha2A receptor, Alpha2B receptor, Alpha2C receptor, Alpha2D receptor, Beta1 receptor, Beta2 receptor, Beta3 receptor, Dopamine beta-hydroxylase, Phenylethanolamine N-Methyltransferase, S-Adenosylmethionine
Neurons that have Norepinephrine as their neurotransmitter
Facts about NorepinephrineRDF feed
| Abbrev | NE + |
| Comment | taken from DrugBank |
| CurationStatus | uncurated + |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00368 + |
| Definition | Precursor of epinephrine that is secreted … Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. (PubChem) Pharmacology: Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance. Mechanism of action: Norepinephrine functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action). Drug type: Approved. Small Molecule. Drug category: Adrenergic alpha-Agonists. Sympathomimetics. Vasoconstrictor Agents . Sympathomimetics. Vasoconstrictor Agents |
| Has role | Drug +, Neurotransmitter +, and Hormone + |
| Id | DB00368 + |
| Is part of | Catecholamine system +, Adrenergic system +, and Noradrenergic system + |
| Label | Norepinephrine + |
| ModifiedDate | 6 May 2010 + |
| RelatedTo | Beta1 receptor +, Alpha2A receptor +, Alpha2C receptor +, Sodium-dependent noradrenaline transporter +, Alpha1A receptor +, Alpha2B receptor +, Alpha1B receptor +, Beta2 receptor +, Alpha1D receptor +, Phenylalanine-4-hydroxylase +, and Beta3 receptor + |
| SuperCategory | Molecule + |
| Synonym | Arterenol +, L-Norepinephrine +, L-noradrenaline +, Noradrenaline +, Norepinephrine +, and Levophed + |