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Olfactory bulb (main) mitral cell

Name: Olfactory bulb (main) mitral cell
Description: Principal neuron located in the olfactory bulb in the mammalian central nervous system. The cell bodies are arranged in a thin layer between the granule cell layer and the external plexiform layer. Each mitral cell is usually characterized in the mammal by a single primary dendrite that traverses the external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches which receives input from the axons of olfactory receptor neurons. Axons of the mitral cells project to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala.
Synonym(s): Mitral neuron
Has role: Principal neuron role
Abbreviation: MC
Super-category: Neuron
URL: Shepherd, Chen and Greer (2004). Olfactory bulb. In The Synaptic Organization of the Brain, ed 5. New York: Oxford University Press.
Id: nifext_120
Defining criteria: Morphology; Connectivity; Biochemical
Organism: Mammal
Link to OWL / RDF: Download this content as OWL/RDF

Soma Specific Properties

Cell Soma Shape: Mitral
Cell Soma Size: Large soma
Soma Location: Olfactory bulb main mitral cell body layer

Dendrite Specific Properties

Spine density on dendrites: Smooth

Axon Specific Properties

Axon myelination: myelinated
Axon projection laterality: ipsilateral
Origin of axon: soma and sometimes dendrite
Location of distant axon arborization: olfactory cortex
Location of local axon arborization: Olfactory bulb main granule cell layer, Olfactory bulb main external plexiform layer

Intrinsic Properties

Neurotransmitter released: Glutamate
Neurotransmitter receptors: GABA_Receptor, AMPA-type glutamate-gated cationic channel, NMDA, GABA A-gated anionic channel, GABA-B Receptor
Molecular constituents: T-box protein 21, Protocadherin gamma-C3
Defining Criteria: Morphology; Connectivity; Biochemical


Notes

This page uses this default form:Petilla_neuron



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Facts about Olfactory bulb (main) mitral cellRDF feed
AbbrevMC  +
AxonDiameterRat: 1 um  +
AxonLengthseveral mm  +
AxonMyelinationmyelinated  +
AxonProjectionLateralityipsilateral  +
CellSomaShapeCategory:Mitral   +
CellSomaSizeLarge soma  +
CellularSynapticTargetOlfactory bulb (main) granule cell  +, Intrinsic: granule cells in granule cell layer and external plexiform layer; possibly Blanes cells in granule cell layer; Extrinsic  +, and Pyramidal cells of olfactory cortex; superficial interneurons of olfactory cortex  +
Created5 September 2007  +
CurationStatusgraph position temporary  +
DefiningCitationShepherd, Chen and Greer (2004). Olfactory bulb. In The Synaptic Organization of the Brain, ed 5. New York: Oxford University Press.  +
DefiningCriteriaMorphology; Connectivity; Biochemical  +
DefinitionPrincipal neuron located in the olfactory Principal neuron located in the olfactory bulb in the mammalian central nervous system. The cell bodies are arranged in a thin layer between the granule cell layer and the external plexiform layer. Each mitral cell is usually characterized in the mammal by a single primary dendrite that traverses the external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches which receives input from the axons of olfactory receptor neurons. Axons of the mitral cells project to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala. cortex, olfactory tubercle, and amygdala.
DendriteLengthRat: Apical trunk: 400-500 um; apical tuft: 70-150 um; basal: up to 1 mm  +
DendriteThicknessRat: Apical trunk: 2-6; apical tuft: 1-2 um at origin; basal: 2-3 um at origin, narrowing through branching to less than 1 um.  +
EditorialNotehttp://senselab.med.yale.edu/neurondb/Neur http://senselab.med.yale.edu/neurondb/NeuronProp.aspx?id=267 I changed protocadherin-2 to Protocadherin gamma-C3, as that seems to be the preferred name in NCBI and the Protein Ontology. Changed TBX-21 to T-box protein 21, to distinguish it from the gene. Please let me know if these changes aren't appropriate. know if these changes aren't appropriate.
ExampleImageOlfactory bulb (main) mitral cell.gif  +
FiringPatternsRegular firing and bursting  +
Has default formThis property is a special property in this wiki.Petilla neuron  +
Has rolePrincipal neuron role  +
Idnifext_120  +
LabelOlfactory bulb (main) mitral cell  +
Located inOlfactory bulb main mitral cell body layer  +
LocationOfAxonArborizationOlfactory cortex  +
LocationOfLocalAxonArborizationOlfactory bulb main granule cell layer  +, and Olfactory bulb main external plexiform layer  +
ModifiedDate9 July 2012  +
MolecularConstituentsT-box protein 21  +, and Protocadherin gamma-C3  +
NeurotransmitterGlutamate  +
NeurotransmitterReceptorsGABA receptor  +, AMPA-type glutamate-gated cationic channel  +, NMDA  +, GABA A-gated anionic channel  +, and GABA-B Receptor  +
NumberOfPrimaryDendrites1 (applies to most mammals)  +
OriginOfAxonsoma and sometimes dendrite  +
Page has default formThis property is a special property in this wiki.Petilla neuron  +
PassiveSubthresholdParametersRN, 20=50 megohm  +
SpeciesMammal  +
SpikingFeaturessame  +
SpineDensityOnDendritesSmooth  +
SpontaneousFiringPatternsRegular firing and bursting  +
SpontaneousFiringRatemedium firing  +
SubcellularSynapticTargetIntrinsic: Dendrodendritic synapses on granule cell dendritic spines. Extrinsic: Axon in olfactory cortical areas on apical dendritic spines of pyramidal cells and dendrites of superficial interneurons  +
SuperCategoryNeuron  +
SynapticPhysiologyOutput synapses at both dendrodendritic and axodendritic synapses: GLU NMDA, AMPA; input synapses: GABA from granule cell dendrodendritic synapses  +
SynonymMitral neuron  +