arrow

From NeuroLex

Jump to: navigation, search



Oxytocin

Name: Oxytocin
Description: Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity. Pharmacology: Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term. Mechanism of action: Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. Drug type: Approved. Biotech. Drug category: Anti-tocolytic Agents. Labor Induction Agents. Oxytocics
Synonym(s): Pitocin, Syntocinon, Oxytocin (BAM Biotech), Pitocin (Parke-Davis), Syntocinon (Sandoz)
Related to: Oxytocin-neurophysin 1, Prolyl endopeptidase
Has role: Drug, Neuropeptide
Super-category: Peptide
URL: http://www.drugbank.ca/drugs/DB00107
Id: CHEBI: 7872
Link to OWL / RDF: Download this content as OWL/RDF

Neurons that have Oxytocin as their neurotransmitter

Hypothalamus oxytocin neuroendocrine magnocellular cell




bookmark
Facts about OxytocinRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00107  +
DefinitionSynthetic 9 residue cyclic peptide. The ho Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity. Pharmacology: Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term. Mechanism of action: Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. Drug type: Approved. Biotech. Drug category: Anti-tocolytic Agents. Labor Induction Agents. Oxytocics Agents. Labor Induction Agents. Oxytocics
Has roleDrug  +, and Neuropeptide  +
IdCHEBI: 7872  +
LabelOxytocin  +
ModifiedDate16 March 2010  +
RelatedToOxytocin-neurophysin 1  +, and Prolyl endopeptidase  +
SuperCategoryPeptide  +
SynonymPitocin  +, Syntocinon  +, Oxytocin (BAM Biotech)  +, Pitocin (Parke-Davis)  +, and Syntocinon (Sandoz)  +