arrow

From NeuroLex

Jump to: navigation, search



Pentobarbital

Name: Pentobarbital
Description: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) Pharmacology: Pentobarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. Mechanism of action: Pentobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission. Drug type: Approved. Small Molecule. Drug category: Adjuvants, Anesthesia. Barbiturates. GABA Modulators. Hypnotics and Sedatives
Synonym(s): Pentabarbital, Pentabarbitone, Pentobarbital Sodium, Pentobarbitone, Pentobarbiturate, Pentobarbituric acid, Sodium Pentobarbital, Dorsital, Ethaminal, Mebubarbital, Mebumal, Nebralin, Nembutal, Nembutal Sodium, Neodorm, Rivadorm
Related to: Gamma-aminobutyric-acid receptor subunit alpha-1
Has role: Drug, Drug of abuse role
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00312
Id: CHEBI_7983
Link to OWL / RDF: Download this content as OWL/RDF




bookmark
Facts about PentobarbitalRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00312  +
DefinitionA short-acting barbiturate that is effecti A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) Pharmacology: Pentobarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. Mechanism of action: Pentobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission. Drug type: Approved. Small Molecule. Drug category: Adjuvants, Anesthesia. Barbiturates. GABA Modulators. Hypnotics and Sedatives . GABA Modulators. Hypnotics and Sedatives
Has roleDrug  +, and Drug of abuse role  +
IdCHEBI_7983  +
LabelPentobarbital  +
ModifiedDate16 November 2010  +
RelatedToGamma-aminobutyric-acid receptor subunit alpha-1  +
SuperCategoryMolecular entity  +
SynonymPentabarbital  +, Pentabarbitone  +, Pentobarbital Sodium  +, Pentobarbitone  +, Pentobarbiturate  +, Pentobarbituric acid  +, Sodium Pentobarbital  +, Dorsital  +, Ethaminal  +, Mebubarbital  +, Mebumal  +, Nebralin  +, Nembutal  +, Nembutal Sodium  +, Neodorm  +, and Rivadorm  +