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Phenobarbital

Name: Phenobarbital
Description: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. (PubChem) Pharmacology: Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Mechanism of action: Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. Drug type: Approved. Small Molecule. Drug category: Anticonvulsants. Excitatory Amino Acid Antagonists. GABA Modulators. Hypnotics and Sedatives
Synonym(s): Fenobarbital, Phenobarbitol, Phenobarbituric Acid, Phenylethylbarbiturate, Phenylethylbarbituric Acid, Phenylethylmalonylurea, Adonal, Aephenal, Agrypnal, Amylofene, Aphenylbarbit, Aphenyletten, Barbenyl, Barbinal, Barbiphen, Barbiphenyl, Barbipil, Barbita, Barbivis, Barbonal, Barbophen, Bardorm, Bartol, Bialminal, Blu-Phen, Cabronal, Calmetten, Calminal, Cardenal, Chinoin, Codibarbita, Coronaletta, Cratecil, Damoral, Dezibarbitur, Dormina, Dormiral, Dormital, Doscalun, Duneryl, Ensobarb, Ensodorm, Epanal, Epidorm, Epilol, Episedal, Epsylone, Eskabarb, Etilfen, Euneryl, Fenbital, Fenemal, Fenosed, Fenylettae, Gardenal, Gardepanyl, Glysoletten, Haplopan, Haplos, Helional, Hennoletten, Henotal, Hypnaletten, Hypnette, Hypno-Tablinetten, Hypnogen, Hypnolone, Hypnoltol, Hysteps, Lefebar, Leonal, Lephebar, Lepinal, Lepinaletten, Linasen, Liquital, Lixophen, Lubergal, Lubrokal, Lumen, Lumesettes, Lumesyn, Luminal, Lumofridetten, Luphenil, Luramin, Molinal, Neurobarb, Nirvonal, Noptil, Nova-Pheno, Nunol, Parkotal, Pharmetten, Phen-Bar, Phenaemal, Phenemal, Phenemalum, Phenobal, Phenobarbyl, Phenoluric, Phenolurio, Phenomet, Phenonyl, Phenoturic, Phenyletten, Phenyral, Phob, Polcominal, Promptonal, Seda-Tablinen, Sedabar, Sedicat, Sedizorin, Sedlyn, Sedofen, Sedonal, Sedonettes, Sevenal, Sinoratox, Solfoton, Solfoton Talpheno, Solu-Barb, Sombutol, Somnolens, Somnoletten, Somnosan, Somonal, Spasepilin, Starifen, Starilettae, Stental, Stental Extentabs, Talpheno, Teolaxin, Teoloxin, Thenobarbital, Theoloxin, Triabarb, Tridezibarbitur, Triphenatol, Versomnal, Zadoletten, Zadonal
Related to: Gamma-aminobutyric-acid receptor subunit alpha-1
Has role: Drug, Drug of abuse role
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB01174
Id: CHEBI_8069
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB01174  +
DefinitionA barbituric acid derivative that acts as A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. (PubChem) Pharmacology: Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Mechanism of action: Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. Drug type: Approved. Small Molecule. Drug category: Anticonvulsants. Excitatory Amino Acid Antagonists. GABA Modulators. Hypnotics and Sedatives . GABA Modulators. Hypnotics and Sedatives
Has roleDrug  +, and Drug of abuse role  +
IdCHEBI_8069  +
LabelPhenobarbital  +
ModifiedDate16 November 2010  +
RelatedToGamma-aminobutyric-acid receptor subunit alpha-1  +
SuperCategoryMolecular entity  +
SynonymFenobarbital  +, Phenobarbitol  +, Phenobarbituric Acid  +, Phenylethylbarbiturate  +, Phenylethylbarbituric Acid  +, Phenylethylmalonylurea  +, Adonal  +, Aephenal  +, Agrypnal  +, Amylofene  +, Aphenylbarbit  +, Aphenyletten  +, Barbenyl  +, Barbinal  +, Barbiphen  +, Barbiphenyl  +, Barbipil  +, Barbita  +, Barbivis  +, Barbonal  +, Barbophen  +, Bardorm  +, Bartol  +, Bialminal  +, Blu-Phen  +, Cabronal  +, Calmetten  +, Calminal  +, Cardenal  +, Chinoin  +, Codibarbita  +, Coronaletta  +, Cratecil  +, Damoral  +, Dezibarbitur  +, Dormina  +, Dormiral  +, Dormital  +, Doscalun  +, Duneryl  +, Ensobarb  +, Ensodorm  +, Epanal  +, Epidorm  +, Epilol  +, Episedal  +, Epsylone  +, Eskabarb  +, Etilfen  +, Euneryl  +, Fenbital  +, Fenemal  +, Fenosed  +, Fenylettae  +, Gardenal  +, Gardepanyl  +, Glysoletten  +, Haplopan  +, Haplos  +, Helional  +, Hennoletten  +, Henotal  +, Hypnaletten  +, Hypnette  +, Hypno-Tablinetten  +, Hypnogen  +, Hypnolone  +, Hypnoltol  +, Hysteps  +, Lefebar  +, Leonal  +, Lephebar  +, Lepinal  +, Lepinaletten  +, Linasen  +, Liquital  +, Lixophen  +, Lubergal  +, Lubrokal  +, Lumen  +, Lumesettes  +, Lumesyn  +, Luminal  +, Lumofridetten  +, Luphenil  +, Luramin  +, Molinal  +, Neurobarb  +, Nirvonal  +, Noptil  +, Nova-Pheno  +, Nunol  +, Parkotal  +, Pharmetten  +, Phen-Bar  +, Phenaemal  +, Phenemal  +, Phenemalum  +, Phenobal  +, Phenobarbyl  +, Phenoluric  +, Phenolurio  +, Phenomet  +, Phenonyl  +, Phenoturic  +, Phenyletten  +, Phenyral  +, Phob  +, Polcominal  +, Promptonal  +, Seda-Tablinen  +, Sedabar  +, Sedicat  +, Sedizorin  +, Sedlyn  +, Sedofen  +, Sedonal  +, Sedonettes  +, Sevenal  +, Sinoratox  +, Solfoton  +, Solfoton Talpheno  +, Solu-Barb  +, Sombutol  +, Somnolens  +, Somnoletten  +, Somnosan  +, Somonal  +, Spasepilin  +, Starifen  +, Starilettae  +, Stental  +, Stental Extentabs  +, Talpheno  +, Teolaxin  +, Teoloxin  +, Thenobarbital  +, Theoloxin  +, Triabarb  +, Tridezibarbitur  +, Triphenatol  +, Versomnal  +, Zadoletten  +, and Zadonal  +