From NeuroLex
Principal neuron
| Name: | Principal neuron |
| Description: | A neuron with role projection neuron role, i.e., a neuron whose axon projects out of the brain region in which its soma lies |
| Synonym(s): | Projection neuron, principal cell |
| Super-category: | Defined neuron class |
| Id: | nlx_cell_1003112 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Categories with role Principal neuron
Neocortex pyramidal cell, Neocortex pyramidal cell layer 5-6, Olfactory bulb (main) tufted cell (middle) have the role Principal neuron
- This table is generated programmatically from the property "Role" assigned to members of the Neuron class. To add to this list, go to the category page for the type of neuron you are interested in adding and add "Principal neuron role" to the "Has role" field in the Petilla form.
This table is also available in CSV
Overview
A
- Accessory nucleus motor neuron
- Amygdala basolateral nuclear complex pyramidal neuron
- Amygdala intercalated nuclei small spiny neuron
- Amygdala lateral central nucleus medium spiny neuron
- Antennal lobe (Honey bee) principal neuron
- Antennal lobe (Manduca) principal neuron
C
- Cerebellum Purkinje cell
- Cochlea inner hair cell
- Cochlea outer hair cell
- Cochlear nucleus (dorsal) giant cell
- Cochlear nucleus (ventral) bushy cell
- Cochlear nucleus (ventral) globular bushy cell
- Cochlear nucleus (ventral) multipolar T cell
- Cochlear nucleus (ventral) octopus cell
- Colliculus Inferior GABAergic Principal Cell
- Colliculus inferior principal cell
- Colliculus superior stellate neuron
- Colliculus superior wide field vertical cell
D
F
G
H
- Head direction cell
- Hippocampus CA1 pyramidal cell
- Hippocampus CA3 pyramidal cell
- Hypoglossal nucleus motor neuron
L
M
N
- Neocortex polymorphic cell layer 5-6
- Neocortex primary motor area pyramidal layer 2-3 cell
- Neocortex primary motor area pyramidal layer 5 callosal cell
- Neocortex primary motor area pyramidal layer 5 corticopontine-tectal cell
- Neocortex primary motor area pyramidal layer 5 corticospinal cell
- Neocortex primary motor area pyramidal layer 5 corticostriate cell
- Neocortex primary motor area pyramidal layer 6 cell
- Neocortex primary visual area pyramidal layer 2-3 cell
- Neocortex primary visual layer 5 callosal cell
- Neocortex primary visual layer 5 corticopontine/tectal pyramidal cell
- Neostriatum direct pathway spiny neuron
- Neostriatum indirect pathway spiny neuron
N cont.
O
R
S
- Solitary tract nucleus HSD2 neuron
- Spinal cord border cell
- Spinal cord ventral horn motor neuron alpha
- Spinal cord ventral horn motor neuron gamma
- Stomatogastric ganglion anterior burster neuron
- Substantia nigra pars compacta dopaminergic cell
- Suprachiasmatic nucleus principal neuron
T
- Thalamus geniculate nucleus (medial) principal neuron
- Trapezoid body medial nucleus principal cell
- Trigeminal nucleus motor neuron
- Tritonia dorsal swim interneuron
- Trochlear nucleus motor neuron
- Tuberomammillary nucleus large histamine neuron
V
Detail
| Id | Neurotransmitter | Synonym | Definition | Located in | |
|---|---|---|---|---|---|
| Accessory nucleus motor neuron | nlx_83979 | Acetylcholine | spinal accessory nerve acessory nucleus motor cell 11th nerve motor neuron XIth nerve motor neuron |
Motor neuron whose cell soma lies within the Acessory nucleus. | |
| Amygdala basolateral nuclear complex pyramidal neuron | nifext_152 | Glutamate | Pyramidal cell basolateral amygdalar nucleus Amygdala basolateral nucleus pyramidal neuron |
These neurons make up ~80-85% of neurons in the basolateral nuclear complex of the amygdala. Unlike cortical pyramidal cells, they are not arranged with parellel apical dendrites but are randomly organized. | Basolateral nuclear complex |
| Amygdala intercalated nuclei small spiny neuron | nlx_149095 | GABA | paracapsular intercalated cell (ITC) | Small spiny principal neurons of the intercalated nuclei. These nuclei are clusters of neurons surrounding rostral portions of the basolateral nuclear complex. Some of these clusters are located adjacent to the external capsule or intermediate capsule (paracapsular intercalated nuclei). | Intercalated amygdaloid nuclei |
| Amygdala lateral central nucleus medium spiny neuron | nlx_149094 | GABA | Medium-sized, multipolar, principal neuron found in lateral portions of the central nucleus. It has very spiny dendrites and closely resembles the medium spiny neuron of the adjacent striatum. | Central amygdaloid nucleus | |
| Antennal lobe (Honey bee) principal neuron | nlx_151564 | Acetylcholine | Antennal lobe principal neuron | Projection neuron of the honey bee, Apis mellifera,whose soma is located on the rind of the antennal lobe.The axons of uniglomerular projection neurons project to the mushroom body calyx and to the lateral horn in the protocerebral lobe.The axons of the multiglomerular projction neurons project to the protocebral lobe only. | Antennal lobe rind |
| Antennal lobe (Manduca) principal neuron | nlx_151688 | Acetylcholine | uniglomerular projection neuron medial-antenno-protocerebral-tract projection neuron inner-antennocerebral-tract projection neuron |
uniglomerular principal neuron in the antennal lobe of the tobacco hornworm moth, in neuronal cell groups on the border of the antennal lobe, mainly medial and anterior cell groups. It likely uses acetylcholine as a transmitter. The axon projects to lateral protocerebrum with collaterals in the mushroom body. | Antennal lobe |
| Cerebellum Purkinje cell | sao471801888 | GABA | Purkinje neuron Purkinje's corpuscles Cerebellar Purkinje neuron Purkinje Cell Purkyne cell Corpuscles of Purkinje cerebellar purkinje cell |
Principal neuron (projection neuron) of the cerebellar cortex; cell bodies arranged in a single layer; characterized by a pear-shaped cell body, 1 (rarely 2) primary dendrites and an elaborate dendritic tree heavily invested with dendritic spines. | Cerebellum Purkinje cell layer of cerebellar cortex |
| Cochlea inner hair cell | sao429277527 | Glutamate | Cochlear Inner Hair Cell Inner Hair Cell |
A pear-shaped epithelial cell that is medially placed re: the inner pillar and forms a single row within the organ of Corti. Resting potential is modulated by perturbations in stereocilia located at the apical pole of the cell. In contrast to outer hair cells, the inner hair cells are fewer in number, have fewer stereocilia, and are less differentiated. They do, however, receive ~95% of the auditory-nerve dendrites. Although a single auditory nerve fiber innervates several outer hair cells, each inner hair cell receives several more heavily myelinated, auditory-nerve dendrites. Neurotransmitter release activates the auditory nerve, which leads to the cochlear nucleus within the central auditory pathway.(MSH) | Spiral organ of Corti |
| Cochlea outer hair cell | sao1582628662 | Glutamate or aspartate | Cochlear Outer Hair Cell Outer Hair Cell |
In mammals, the outer hair cells are arranged in three rows that are further removed from the modiolus than the single row of inner hair cells. Although receiving only ~5% of the innervating auditory nerve dendrites, the motile properties of the outer hair cells actively contribute to the sensitivity and frequency selectivity of the cochlea. The process of somatic electromotility, due to the presence of the motor protein, prestin, is essential for normal cochlear function. Outer hair cell function is also directly influenced by efferent input from the medial superior olivary complex. (MSH) | Cochlea Spiral organ of Corti |
| Cochlear nucleus (dorsal) giant cell | nifext_75 | Giant cell | Large multipolar cells located in the depths of the dorsal cochlear nucleus. Like the pyramidal (fusiform) cells, a principal neuron of the DCN. Their dendrites, branching sparsely across isofrequency bands, are smooth until they reach the molecular layer, where the tips are spiny. The axons join pyramidal cell axons to form the DAS (dorsal acoustic stria) through which they project to the contralateral inferior colliculus. | Depths of dorsal cochlear nucleus | |
| Cochlear nucleus (ventral) bushy cell | nlx_cell_20081201 | Glutamate | Bushy neuron Bushy cell ventral cochlear nucleus bushy cell |
Bushy cells in the anteroventral cochlear nucleus have one to four primary dendrites which branch profusely, giving them a "bushy" appearance. They project to the superior olivary nuclei. They carry information that is used to localize sounds in the azimuthal plane. Three types of bushy cells differ in the shapes of their somata and in their patterns of projection. The cell somata of these neurons have been described as "spherical" in the anterior division of the AVCN and "globular" in the posterior division of the AVCN. Large spherical bushy cells project to the medial superior olivary nuclei bilaterally, globular bushy cells project to the contralateral medial nucleus of the trapezoid body. Small spherical bushy cells project to the vicinity of the ipsilateral lateral superior olivary nucleus but it is not yet clear which cells are their targets. Their inputs from the spiral (cochlear) ganglion arise via the end bulbs of Held. | Ventral cochlear nucleus |
| Cochlear nucleus (ventral) globular bushy cell | nifext_70 | Glutamate | The distinction between globular and spherical bushy cells was originally reported by Osen on the basis of a difference in the shape of the cell bodies. Globular bushy cells lie in and around the root of the auditory nerve. Their axons project to the contralateral medial nucleus of the trapezoid body (MNTB), innervating principal cells with a calyx of Held. | Ventral cochlear nucleus | |
| Cochlear nucleus (ventral) multipolar T cell | nifext_68 | Glutamate | T multipolar cell T stellate cell type I chopper planar multipolar |
Principal cells of the ventral cochlear nucleus are named for having the axon exit the cochlear nucleus through the Trapezoid body. A band of dendrites in an isofrequency lamina receives input from a small number of auditory nerve fibers. Sharp tuning is enhanced by sideband inhibition. The population of T stellate cells encodes the spectra of sounds. | Ventral cochlear nucleus |
| Cochlear nucleus (ventral) octopus cell | nifext_72 | Glutamate | Ventral cochlear nucleus octopus cell octopus cell |
Large neuron located in the octopus cell area of the posterior division of the ventral cochlear nucleus (called dorsal tail of the ventral cochlear nucleus by Cajal and nucleus interfascicularis by Lorente de No), whose dendrites emanate from one side of the cell body, giving them a shape reminiscent of an octopus. | Cochlear nuclear complex Ventral cochlear nucleus Octopus cell area Dorsal tail of ventral cochlear nucleus Nucleus interfascicularis |
| Colliculus Inferior GABAergic Principal Cell | nlx_60854 | GABA | large GABAergic (LG) neurons | Winer and colleagues (1996) first described that GABAergic neurons project to the medial geniculate body in cat. Peruzzi et al. (1997) showed that the cell type is also found in rats, and sends action potentials more rapidly than glutamatergic IC neurons. Ito and colleagues (2009) showed that the cell type is the largest neuron in the IC and receives dense VGLUT2-positive axosomatic terminals on the cell body. Other cell types such as glutamatergic neurons and small GABAergic neurons do not have such endings. | Inferior colliculus |
| Colliculus inferior principal cell | nifext_82 | Glutamate | Inferior colliculus principal neuron | Around 80% of neurons in the inferior colliculus (IC) is glutamatergic (Ito and Oliver, 2012). They express vesicular glutamate transporter (VGLUT) 2 but not VGLUT1 or VGLUT3 (Ito and Oliver, 2010, 2011). Their main target is the medial geniculate body although they send axons to most auditory brainstem nuclei. Since majority of IC neurons are disc-shaped, which extend their dendrite parallel to isofrequency laminae (Oliver, 1984), majority of glutamatergic neurons are likely to be disc-shaped. Stellate neurons, which are less common and extend dendrite perpendicular to isofrequency laminae, also project to the medial geniculate body (Oliver, 1984). | Inferior colliculus |
| Colliculus superior stellate neuron | BAMSC1129 | stellate neuron | The third major category of cells in the superior colliculus is the stellate cell. The cells are defined by the lack of overall orientation to the dendritic fields which extend symmetrically from the cell body. Stellate cells are multipolar with dendrites arising from any portion of the cell body. The dendrites may range anywhere from gnarled to radiate with the gnarled spiny cells most frequent in the zone of horizontal cells and the smooth radiate cells increasingly more frequent in the deeper zones until they are almost the only cell type in the zones below the stratum opticum. The dimensions of the cell bodies and dendritic fields are comparable to those of other cells in the same zone and the dendritic field is generally contained within the same zone as the cell body. The axons of stellate cells have both local and/or distant distributions and a morphology characteristic of intrinsic axons. As with all the other cell types, the axon may take its origin from the cell body or a low order dendrite. | Superior colliculus | |
| Colliculus superior wide field vertical cell | BAMSC1125 | wide field vertical cell | There are two similar populations in the group of wide field vertical cells. The first lies in the deep margin of the zone of vertical cells where it looks very similar to the piriform cells relative to the zone of horizontal cells. Cajal called these the ovoid or triangular cells. The second population has its cell bodies distributed primarily to the upper portion of the zone of optic fibers. Cajal called these triangular or stellate cells. Cajal's nomenclature is rather bulky and, though descriptive, somewhat confusing because stellate cells are a distinct cell type in the nomenclature of this paper and triangular occurs in both names. For reasons developed below, the ovoid or triangular cells or wide field cells of the zone of vertical cells will be called Type II ganglion cells and the triangular or stellate cells or wide field cells of the zone of optic fibers will be called Type III ganglion cells. Type I ganglion cells are the piriform cells. Collator note: we assumed this class of neurons as projection neurons, because at least several subpopulations project to visually related areas. See Sefton et al., 2005; Mason and Groos, 1981; Mackay to Sim et al. 1983; Okoyama and Kudo, 1987). | Superior colliculus | |
| Dorsal motor nucleus of vagus motor neuron | nlx_38336 | Acetylcholine | Motor neuron whose cell soma lies within the dorsal motor nucleus of the vagus, the principal parasympathetic nucleus of the brain. | Dorsal motor nucleus of vagus nerve | |
| Facial nucleus motor neuron | nlx_50129 | Acetylcholine | facial nucleus motor cell 7th nerve motor neuron VIIth nerve motor neuron |
Motor neuron whose cell soma lies within the facial nucleus. | Facial nucleus |
| Globus pallidus principal cell | nifext_149 | GABA | Large neuron of he globus pallidus, both internal and external segment, characterized by a large and fusiform or trangular cell soma with long, thick aspiny dendrites that may extend for over 1 mm. | Globus pallidus | |
| Grid cell | nlx_144209 | a neuron which fires when an animal is in any point of space which corresponds to a vertex of its triangular grid firing field. | Entorhinal cortex | ||
| Head direction cell | nlx_144208 | Head-direction cell | Neurons which fire when an animal's head is facing in a particular direction of horizontal plane, regardless of location, behavior or position of body | Postsubiculum Anterior Thalamus Lateral mammillary nucleus |
|
| Hippocampus CA1 pyramidal cell | sao830368389 | Glutamate | Hippocampal CA1 Pyramidal Neuron CA1 pyramidal neuron Hippocampal CA1 pyramidal cell |
Pyramidal neuron with a soma located in hippocampal area CA1. It receives input from Schaffer collaterals of CA3 pyramidal neurons, and sends its axon to the subiculum and entorhinal cortex. | CA1 stratum pyramidale |
| Hippocampus CA3 pyramidal cell | sao383526650 | Glutamate | Hippocampal CA3 Pyramidal Neuron CA3 pyramidal neuron CA3 pyramidal cell |
This is the major output neuron in area CA3 of the hippocampus. It receives input from mossy fibers of the dentate gyrus. Its axon projects to the contralateral hippocampus and subcortically to the septal nucleus, and sends axon collaterals called Shaffer collaterals to the nearby CA1 region. | CA3 stratum pyramidale |
| Hypoglossal nucleus motor neuron | nlx_cell_100311 | Acetylcholine | hypoglossal motor neuron hypoglossal nucleus motoneuron hypoglossal motoneuron 12th nerve motor neuron XII nerve motor neuron |
Motor neuron whose soma lies in the hypoglossal nucleus | Hypoglossal nucleus |
| Locus coeruleus NA neuron | nlx_cell_20090202 | Norepinephrine | Locus coeruleus noradrenergic neuron | Locus ceruleus | |
| Mauthner cell | nlx_151908 | Acetylcholine | M-cell | Giant reticulospinal neuron found in brainstem of most teleosts | Brainstem |
| Neocortex polymorphic cell layer 5-6 | nifext_51 | polymorphic cell Layer 5-6 polymorphic cell Neocortex polymorphic neuron layer 5-6 |
Neocortex layer 5 Neocortex layer 6 |
||
| Neocortex primary motor area pyramidal layer 2-3 cell | nlx_151707 | Glutamate | Superficial cortical pyramidal cell | This basic neuron type in the neocortex has a pyramidal-shaped cell body with apical and basal dendrites, with an axon that projects to other cortical areas as well giving rise to local collaterals. | Neocortex layer 2 Neocortex layer 3 |
| Neocortex primary motor area pyramidal layer 5 callosal cell | nlx_152138 | Glutamate | This is a basic type of neocortical cell with a pyramidal shaped cell body and apical and basal spiny dendrites. Its axon gives off local collaterals and projects through the corpus callosum to the contralateral neocortex. It belongs to the group termed intra-telencepalic pyramidal cells. | Neoortical layer 5 | |
| Neocortex primary motor area pyramidal layer 5 corticopontine-tectal cell | nlx_152139 | Glutamate | This is a basic type of necortical cell with a pyramidal-shaped cell body and apical and basal spiny dendrites. Its axon projects subcortically to the midbrain tectum, and gives off local collaterals with the necortex. It belongs to the group termed infra-telencenphalic pyramidal cells. | Neocortex layer 5 | |
| Neocortex primary motor area pyramidal layer 5 corticospinal cell | nlx_151709 | Glutamate | Upper motor neuron corticospinal neuron Betz cell |
This is a basic type of neocortical cell with a pyramidal-shaped cell body and apical and basal spiny dendrites. It has an axon that projects subcortically to the spinal cord, giving off collaterals to the thalamus, and local collaterals within the cortex. It belongs to the group termed infra-telencephalic pyramidal cells. | Neocortex layer 5B |
| Neocortex primary motor area pyramidal layer 5 corticostriate cell | nlx_152140 | Glutamate | Cortico-striate cell | This is a basic type of neocortical cell with a pyramidal-shaped cell body and basal and apical spiny dendrites. Its axon projects to the neostriatum, and gives off local collaterals with the neocortex. It belongs to the group termed intra-telenchephalic. | Neocortex layer 5 |
| Neocortex primary motor area pyramidal layer 6 cell | nlx_152137 | Glutamate | Cortical-thalamic cell | This is a basic type of neocortical cell with a pyramidal shaped cell body and spiny apical and basal dendrites. Its axon projects to the thalamus. | Neocortex layer 6 |
| Neocortex primary visual area pyramidal layer 2-3 cell | nlx_152226 | Glu | Layer 2 Layer 3 |
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| Neocortex primary visual layer 5 callosal cell | nlx_143940 | Neuron in lower layer 5 of primary visual cortex with pyramidal or ovoid soma that project via the corpus callosum to the opposite visual cortex. At the area 17/18 border, callosal neurons are distributed evenly throughout the depth of layer 5. These neurons do not send projections to either the pontine nuclei or the superior colliculus. Apical dendrites of these cells were never observed to extend above layer 4. Basal dendrites were restricted to layer 5 and upper part of layer 6. 2-6 primary basal dendrites originated from the base of the pyramid or ovoid cell body. | Primary visual cortex layer 5 | ||
| Neocortex primary visual layer 5 corticopontine/tectal pyramidal cell | nlx_143938 | Pyramidal neuron with soma located predominantly in the upper middle part of layer 5. These neurons have medium to large somas with 5 or 6 primary basal dendrites (4-7 primary basal dendrites) and a single apical dendrite ascending to layer 1. Double labeling experiments show that these cells send collaterals to the pontine nucleus and the superior colliculus. It is possible that all cells sending projections to these regions send collaterals, but the presence of populations of cells sending projections to only the superior colliculus or the pontine nuclei cannot be ruled out. | Primary visual cortex layer 5 | ||
| Neostriatum direct pathway spiny neuron | nlx_149135 | GABA | Medium spiny neuron Neostriatal spiny neuron Medium-sized spiny neuron Striatal spiny neuron Striatal medium spiny neuron |
The principal projection neuron of the caudate and putamen. | Caudate nucleus Putamen Nucleus accumbens |
| Neostriatum indirect pathway spiny neuron | nlx_149136 | GABA | Medium spiny neuron Neostriatal spiny neuron Medium-sized spiny neuron Striatal spiny neuron Striatal medium spiny neuron |
The principal projection neuron of the caudate and putamen. | Caudate nucleus Putamen Nucleus accumbens |
| Nucleus laminaris principal neuron | nlx_151646 | Glutamate | Analogous to the Medial Superior Olive (MSO) in mammals | The nucleus laminaris (NL) in birds is the third-order auditory neurons located in the brainstem, analogous to the medial superior olive (MSO) in mammals. Neurons in NL and MSO are structurally and biophysically specialized to compute interaural time differences (ITDs), time disparities in the arrival of signals between the two ears, using low-frequency sounds. ITDs are the primary binaural cues for sound localization and segregation in humans and other low-frequency hearing vertebrates. While commonly used laboratory mammals such as mice and rats are high-frequency listeners and have a poorly developed MSO circuit, the structurally and functionally similar circuit in the chicken brainstem provides a particularly useful vertebrate model for basic research of ITD computation, due to its simple anatomy, well-characterized development and cell biology, and importantly, as a genetic tractable system. | Nucleus laminaris |
| Olfactory bulb (main) mitral cell | nifext_120 | Glutamate | Mitral neuron | Principal neuron located in the olfactory bulb in the mammalian central nervous system. The cell bodies are arranged in a thin layer between the granule cell layer and the external plexiform layer. Each mitral cell is usually characterized in the mammal by a single primary dendrite that traverses the external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches which receives input from the axons of olfactory receptor neurons. Axons of the mitral cells project to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala. | Olfactory bulb main mitral cell body layer |
| Olfactory cortex superficial pyramidal cell | nifext_139 | Glutamate | Small pyramidal neuron Olfactory cortex pyramidal neuron |
A cell with the classic pyramidal-shaped cell body and apical and basal dendritic trees, with cell body in layer IIb and superficial layer III of the piriform (olfactory) cortex. Its axon arises from the deeper aspect of the cell body and gives rise to collaterals which terminate within the layer III on local intrinsic cells, and also recur to layer III, II and Ib where they form association fibers that connect to the apical dendrites of pyramidal neurons and continue to become centrifugal fibers to the olfactory bulb. | Olfactory cortex layer IIb and superficial III Olfactory cortex Anterior piriform cortex |
| Retina On-Midget Ganglion Cell | nlx_144271 | Glutamate | P-Cell Retina Ganglion Cell On-Midget |
Physiologically classified as the main ganglion cells with small receptive fields driven by center-On input. Matched with morphologically defined cell of extremely small dendritic arborization. As a population forms both a physical mosaic within retina as well as a receptive field mosaic of stimulus space. Both receptive field size and dendritic arborization are distinct from the corresponding Off-Midget | Retina ganglion cell layer |
| Solitary tract nucleus HSD2 neuron | BAMSC1112 | HSD2 neuron HSD2 cell |
A subgroup of neurons in NTS that express glucocorticoid to inactivating enzyme 11 to beta to hydroxysteroid dehydrogenase type 2 (HSD2), a signature of aldosterone to sensitive tissues. Similar neurons are found in other brain regions. The NTS population may represent a unique phenotype. | Solitary nucleus | |
| Spinal cord border cell | nlx_143585 | Spinal border cell spinal border neuron |
Neuron in the ventral horn of lower thoracic/upper lumbar levels in rat, cat and monkey, regarded as the origin of the ventral spinocerebellar tract | Thoracic spinal cord ventral horn Lumbar spinal cord ventral horn |
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| Spinal cord ventral horn motor neuron alpha | sao1154704263 | Acetylcholine Glutamate |
alpha motoneuron lower motor neuron alpha motor neuron |
Large lower motor neuron of the brainstem and spinal cord. They innervate extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. Alpha motor neurons are distinct from gamma motor neurons, which innervate intrafusal muscle fibers of muscle spindles. | Spinal cord ventral horn |
| Spinal cord ventral horn motor neuron gamma | sao1438006234 | Acetylcholine | fusimotor neuron Gamma motor neuron |
Motor neurons which activate the contractile regions of intrafusal muscle fibers, thus adjusting the sensitivity of the muscle spindles to stretch. Gamma motor neurons may be "static" or "dynamic" according to which aspect of responsiveness (or which fiber types) they regulate. The alpha and gamma motor neurons are often activated together (alpha gamma coactivation) which allows the spindles to contribute to the control of movement trajectories despite changes in muscle length (MSH). | Spinal cord ventral horn |
| Stomatogastric ganglion anterior burster neuron | nlx_152047 | Glutamate | Identified individual neuron. Only non-efferent neuron of the pyloric central pattern generator circuit. Has endogenous bursting properties and is part of the pyloric pacemaker kernel. Graded inhibitory synapses onto pyloric and gastric mill circuit neurons within the stomatogastric ganglion, ascending axons to anterior ganglia. | Stomatogastric ganglion | |
| Substantia nigra pars compacta dopaminergic cell | nifext_145 | Dopamine | substantia nigra dopaminergic cell Nigral dopaminergic cell |
Principal neuron of the substantia nigra pars compacta | Substantia nigra pars compacta |
| Suprachiasmatic nucleus principal neuron | nlx_151894 | Vasopressin Vasoactive intestinal polypeptide Gastrin-releasing peptide GABA Somatostatin Enkephalin |
SCN neuron | Neuron located in the mammalian suprachiasmatic nucleus. Has a role in the generation and/or propagation of circadian rhythms. | Suprachiasmatic nucleus |
| Thalamus geniculate nucleus (medial) principal neuron | nlx_cell_1005001 | Principle neuron in ventral division of medial geniculate nucleu characterized by strongly tufted dendrites, with overall discoid dendritic fields extending dors-ventrally and antero-posteriorly on average of 200 um. Neurons are arranged in parallel laminae, seen in transverse or horizontal sections of the pars lateralis. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1261345/?page=8 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1261345/?page=8 | Ventral nucleus of medial geniculate body | ||
| Trapezoid body medial nucleus principal cell | nifext_79 | Glycine | Principal Cells Medial Nucleus Trapezoid Body Trapezoid body medial nucleus principal neuron |
Principal cell of the medial nucleus of the trapezoid body that receives input from the ventral cochlear nucleus at a specialized synaptic ending termed the Calyx of held. | Medial nucleus of trapezoid body |
| Trigeminal nucleus motor neuron | nlx_44081 | Acetylcholine | trigeminal nucleus motor cell 5th nerve motor neuron Vth nerve motor neuron |
Motor neuron whose cell soma lies within the Motor nucleus of trigeminal nerve | Motor nucleus of trigeminal nerve |
| Tritonia dorsal swim interneuron | Tri0001043 | Serotonin | Cerebral Serotonergic Posterior Neuron Dorsal swim interneuron DSI |
One of three serotonergic neurons on the dorsal surface of the Tritonia cerebral ganglion. Projects an axon contralaterally to the pedal ganglion. Fires stereotypical bursts of action potentials during a swim motor pattern. | Cerebral ganglion |
| Trochlear nucleus motor neuron | nlx_70345 | trochlear nucleus motor cell 4th nerve motor neuron IVth nerve motor neuron |
Motor neuron whose cell soma lies within the trochlear nucleus. | Trochlear nucleus | |
| Tuberomammillary nucleus large histamine neuron | nlx_78845 | Histamine GABA |
Tubermammillary histaminergic neuron | Large neuron in the tubermammillary nucleus that contains histamine and projects widely to the cerebral cortex | Tuberomammillary nucleus |
| Ventral dopaminergic cell | nlx_144018 | Principal neuron of the ventral tegmental area | |||
| Vestibular type 1 hair cell | sao709770772 | Glutamate | A mechanoreceptor hair cell located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. | Otolith organs Semicircular canals |
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| Vestibular type 2 hair cell | nlx_151801 | Glutamate | A mechanoreceptor hair cell located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. | Otolith organs Semicircular canals |
Facts about Principal neuronRDF feed
| CurationStatus | pending final vetting + |
| Definition | A neuron with role projection neuron role, i.e., a neuron whose axon projects out of the brain region in which its soma lies |
| Id | nlx_cell_1003112 + |
| Label | Principal neuron + |
| ModifiedDate | 31 March 2010 + |
| SuperCategory | Defined neuron class + |
| Synonym | Projection neuron +, and principal cell + |



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