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Propranolol

Name: Propranolol
Description: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. (PubChem) Pharmacology: Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity. Mechanism of action: Like atenolol and metoprolol, propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles. Drug type: Approved. Investigational. Small Molecule. Drug category: Adrenergic Agents. Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Anti-anxiety Agents. Antiarrhythmic Agents. Antihypertensive Agents. Vasodilator Agents
Synonym(s): Dl-Propranolol Hydrochloride, Propanalol, Propanolol, Propranalol, Propranolol Hcl, Propranolol Hydrochloride, R, S-Propranolol Hydrochloride, propranolol, Angilol, Apsolol, Avlocardyl, Bedranol, Beprane, Berkolol, Beta-Neg, Beta-Propranolol, Beta-Tablinen, Beta-Timelets, Betachron, Betalong, Cardinol, Caridolol, Corpendol, Deralin, Dociton, Duranol, Efektolol, Elbrol, Etalong, Euprovasin, Frekven, Inderal, Inderal La, Inderide, Indobloc, Innopran XL, Intermigran, Kemi S, Migrastat, Obsidan, Oposim, Prano-Puren, Propanix, Prophylux, Propranolol Hcl Intensol, Propranur, Proprasylyt, Pylapron, Rapynogen, Reducor, Reducor Line, Sagittol, Servanolol, Sloprolol, Sumial, Tesnol
Related to: Beta-1 adrenergic receptor, 5-hydroxytryptamine 1A receptor, Beta-2 adrenergic receptor, 5-hydroxytryptamine 1B receptor, Beta-3 adrenergic receptor
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00571
Id: CHEBI_8499
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Facts about PropranololRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00571  +
DefinitionA widely used non-cardioselective beta-adr A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. (PubChem) Pharmacology: Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity. Mechanism of action: Like atenolol and metoprolol, propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles. Drug type: Approved. Investigational. Small Molecule. Drug category: Adrenergic Agents. Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Anti-anxiety Agents. Antiarrhythmic Agents. Antihypertensive Agents. Vasodilator Agents ntihypertensive Agents. Vasodilator Agents
Has roleDrug  +
IdCHEBI_8499  +
LabelPropranolol  +
ModifiedDate14 April 2014  +
RelatedToBeta-1 adrenergic receptor  +, 5-hydroxytryptamine 1A receptor  +, Beta-2 adrenergic receptor  +, 5-hydroxytryptamine 1B receptor  +, and Beta-3 adrenergic receptor  +
SuperCategoryMolecular entity  +
SynonymDl-Propranolol Hydrochloride  +, Propanalol  +, Propanolol  +, Propranalol  +, Propranolol Hcl  +, Propranolol Hydrochloride  +, R  +, S-Propranolol Hydrochloride  +, propranolol  +, Angilol  +, Apsolol  +, Avlocardyl  +, Bedranol  +, Beprane  +, Berkolol  +, Beta-Neg  +, Beta-Propranolol  +, Beta-Tablinen  +, Beta-Timelets  +, Betachron  +, Betalong  +, Cardinol  +, Caridolol  +, Corpendol  +, Deralin  +, Dociton  +, Duranol  +, Efektolol  +, Elbrol  +, Etalong  +, Euprovasin  +, Frekven  +, Inderal  +, Inderal La  +, Inderide  +, Indobloc  +, Innopran XL  +, Intermigran  +, Kemi S  +, Migrastat  +, Obsidan  +, Oposim  +, Prano-Puren  +, Propanix  +, Prophylux  +, Propranolol Hcl Intensol  +, Propranur  +, Proprasylyt  +, Pylapron  +, Rapynogen  +, Reducor  +, Reducor Line  +, Sagittol  +, Servanolol  +, Sloprolol  +, Sumial  +, and Tesnol  +