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Pyridostigmine
| Name: | Pyridostigmine |
| Description: | A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. (PubChem) Pharmacology: Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Pyridostigmine has a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. Mechanism of action: Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine. Drug type: Approved. Small Molecule. Drug category: Antimyasthenics. Cholinesterase Inhibitors. Parasympathomimetics |
| Synonym(s): | Pyridine N-Oxide, Pyridostigmine Bromide, Pyridostigmine Bromine, Pyridostigminum, Mestinon, Mestinon-SR, Regonol |
| Related to: | Acetylcholinesterase |
| Has role: | Drug |
| Super-category: | Molecule |
| URL: | http://www.drugbank.ca/drugs/DB00545 |
| Id: | DB00545 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Facts about PyridostigmineRDF feed
| Comment | taken from DrugBank |
| Curator | Ab + |
| DefiningCitation | http://www.drugbank.ca/drugs/DB00545 + |
| Definition | A cholinesterase inhibitor with a slightly … A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. (PubChem) Pharmacology: Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Pyridostigmine has a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. Mechanism of action: Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine. Drug type: Approved. Small Molecule. Drug category: Antimyasthenics. Cholinesterase Inhibitors. Parasympathomimetics nesterase Inhibitors. Parasympathomimetics |
| Has role | Drug + |
| Id | DB00545 + |
| Label | Pyridostigmine + |
| ModifiedDate | 4 February 2010 + |
| RelatedTo | Acetylcholinesterase + |
| SuperCategory | Molecule + |
| Synonym | Pyridine N-Oxide +, Pyridostigmine Bromide +, Pyridostigmine Bromine +, Pyridostigminum +, Mestinon +, Mestinon-SR +, and Regonol + |