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Pyridostigmine

Name: Pyridostigmine
Description: A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. (PubChem) Pharmacology: Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Pyridostigmine has a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. Mechanism of action: Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine. Drug type: Approved. Small Molecule. Drug category: Antimyasthenics. Cholinesterase Inhibitors. Parasympathomimetics
Synonym(s): Pyridine N-Oxide, Pyridostigmine Bromide, Pyridostigmine Bromine, Pyridostigminum, Mestinon, Mestinon-SR, Regonol
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00545
Id: DB00545
Related to: Acetylcholinesterase
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Commenttaken from DrugBank
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00545  +
DefinitionA cholinesterase inhibitor with a slightly A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. (PubChem) Pharmacology: Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Pyridostigmine has a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. Mechanism of action: Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine. Drug type: Approved. Small Molecule. Drug category: Antimyasthenics. Cholinesterase Inhibitors. Parasympathomimetics nesterase Inhibitors. Parasympathomimetics
Has roleDrug  +
IdDB00545  +
LabelPyridostigmine  +
ModifiedDate14 April 2014  +
RelatedToAcetylcholinesterase  +
SuperCategoryMolecular entity  +
SynonymPyridine N-Oxide  +, Pyridostigmine Bromide  +, Pyridostigmine Bromine  +, Pyridostigminum  +, Mestinon  +, Mestinon-SR  +, and Regonol  +