3D domain swapping is a mechanism for two or more protein molecules to form a dimer or higher oligomer by exchanging an identical structural element (“domain”). It has been first reported in Diptheria Toxin (1DDT in 3DSwap Knowledgebase).

3DSwap is a novel structural bioinformatics resource that provides the curated information and various sequence and structural features about the proteins involved in 3D domain swapping phenomenon. PDB entries involved in 3D Domain swapping were identified from integrated literature search and searches in PDB using advanced search options. Initial filtering of entries are performed by consulting DIAL Server and PDBSum database. Final list of PDB entries were used for full length literature curation. Publications related to individual PDB entries were curated for specific information related to domain swapping (hinge region, swapped region and other sequence and structural features). Structural Bioinformatics resources like RCSB PDB, SIFTS, PDBSum, PDBe, JOY, PyMol and databases like SCOP and Pfam were used to annotate the individual entries in great detail.