Although InnateDB curation focuses on innate immunity-relevant interactions and pathways, InnateDB also incorporates detailed annotation on the entire human, mouse and bovine interactomes by integrating data (178,000+ interactions & 3,900+ pathways) from several of the major public interaction and pathway databases.

InnateDB also has integrated human, mouse and bovine orthology predictions generated using our Ortholgue software. Ortholgue uses a phylogenetic distance-based method to identify possible paralogs in high-throughput orthology predictions. Integrated human and mouse conserved gene order and synteny information has also been determined to provide further support for orthology predictions.

InnateDB Capabilities:

• View statistics for manually-curated innate immunity relevant molecular interactions. New manually curated interactions are submitted weekly.
• Search for genes and proteins of interest.
• Search for experimentally-verified molecular interactions by gene/protein name, interaction type, cell type, etc.
• Search genes/interactions belonging to 3,900 pathways.
• Visualize interactions using an intuitive subcellular localization-based layout in Cerebral.
• Upload your own list of genes along with associated gene expression data (from up to 10 experimental conditions) to interactively analyze this data in a molecular interaction network context. Once you have uploaded your data, you will be able to interactively visualize interaction networks with expression data overlaid; carry out Pathway, Gene Ontology and Transcription Factor Binding Site over-representation analyses; construct orthologous interaction networks in other species; and much more.
• Access curated interaction data via a dedicated PSICQUIC webservice. data via a dedicated PSICQUIC webservice.