Resource:Adenoma Polyp Tissue Bank
|Name:||Resource:Adenoma Polyp Tissue Bank|
|Description:||The Adenoma Polyp Tissue Bank (APTB) receives whole blood from patients enrolled in the Prevention of Sporadic Colorectal Adenomas with Celecoxib clinical trial. We have reached our accrual on blood submissions, so we will no longer be receiving blood specimens
The objectives of this trial are as follows:
B. To determine the efficacy of celecoxib versus placebo in modulating one or more of a panel of biomarkers for colorectal cancer at the cellular and molecular level sampled in a subset of subjects at selective sites at baseline and after Year 1 and Year 3 of study drug use. These biomarkers will include measurements of aberrant crypt foci (ACF), proliferation (index and crypt distribution), apoptosis (index and crypt distribution), COX expression and activity. If modulation of one or more mucosal biomarkers occur, we will explore whether it correlates with the development of incident colorectal neoplasia (adenomas/carcinomas), thereby attempting to validate the surrogacy of that biomarker.C. To develop a specimen bank. Serum and white blood cells are isolated from whole blood and adenoma tissue blocks and slides are banked. Banked specimens will become available for use in correlative science studies at a later point. This project began in 1999 and will be extended through 2006. The lead principal investigator is Monica M. Bertagnolli, MD, Brigham and Women's Hospital, Boston, MA, and the APTB Director is Scott Jewell, Ph.D., Department of Pathology, The Ohio State University. The APTB is supported by the NIH, NCI Division of Cancer Prevention, in connection with the Strang Cancer Prevention Center, Cornell University, New York.
|Other Name(s):||APTB Specimen Bank|
|Parent Organization:||Resource:Human Tissue Resource Network|
|Resource Type(s):||Biomaterial supply resource|
|Related condition/disease:||Increased risk for colorectal carcinoma|
|Related to:||Resource:One Mind Biospecimen Bank Listing, US Biobank|
|Availability:||Public?: Banked specimens will become available for use in correlative science studies at a later point.|
|Address:||APTB, Innovation Centre, 2001 Polaris Parkway, Columbus, OH - 43240 Phone: 614-293-6906 Fax: 614-293-7013|
|Keywords:||Blood, Serum, White blood cell, Adenoma tissue, Tissue, Whole blood, Block, Slide, Colorectal adenoma, Celecoxib, Adenoma, Cancer, Colorectal cancer, Clinical trial, Polyp, Risk factor|
|Link to OWL / RDF:||Download this content as OWL/RDF|
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|Address||APTB +, Innovation Centre +, 2001 Polaris Parkway +, Columbus +, and OH - 43240 Phone: 614-293-6906 Fax: 614-293-7013 +|
|Availability||Public?: Banked specimens will become available for use in correlative science studies at a later point. +|
|Comment||Sample type: Blood, Serum, White blood cell, Adenoma tissue, Whole blood, Tissue|
|Definition||The Adenoma Polyp Tissue Bank (APTB) recei … The Adenoma Polyp Tissue Bank (APTB) receives whole blood from patients enrolled in the Prevention of Sporadic Colorectal Adenomas with Celecoxib clinical trial. We have reached our accrual on blood submissions, so we will no longer be receiving blood specimens
The objectives of this trial are as follows:
|Has default formThis property is a special property in this wiki.||Resource +|
|Has role||Biomaterial supply resource +|
|Is part of||Resource:Human Tissue Resource Network +|
|Keywords||Blood +, Serum +, White blood cell +, Adenoma tissue +, Tissue +, Whole blood +, Block +, Slide +, Colorectal adenoma +, Celecoxib +, Adenoma +, Cancer +, Colorectal cancer +, Clinical trial +, Polyp +, and Risk factor +|
|Label||Resource:Adenoma Polyp Tissue Bank +|
|Listedby||Resource:One Mind Biospecimen Bank Listing +, and US Biobank +|
|ModifiedDate||30 September 2014 +|
|Page has default formThis property is a special property in this wiki.||Resource +|
|Processing||Block +, and Slide +|
|RelatedTo||Resource:One Mind Biospecimen Bank Listing +, and US Biobank +|
|Related application||Research +|
|Related disease||Increased risk for colorectal carcinoma +|
|Supporting Agency||National Cancer Institute +|
|Synonym||APTB Specimen Bank +|