From NeuroLex
Resource:Allen Institute Mouse Diversity Study
| Name: | Resource:Allen Institute Mouse Diversity Study |
| Description: | A database, and associated atlas, that characterizes gene expression across genetic backgrounds and sex, expanding beyond the adult male C57BL/6J reference brain comprising the Allen Mouse Brain Atlas to include seven strains of male mice and female C57BL/6J mice. Gene expression was detected using colorimetric RNA in situ hybridization (ISH) that provides cellular level anatomic resolution. ISH data are searchable and organized by gene, strain, or sex. This freely accessible online resource allows for simultaneous navigation and comparison of different mouse brains at high resolution, providing users with a dataset to probe for possible differences in gene regulation. For both the strain and sex components of the project, a panel of 49 well known drug target genes that are expressed in the adult and developing brain and encompass sites of action for FDA-approved drugs were assayed. These include genes encoding proteins involved in the synthesis, transport and signaling of neurotransmitters, G protein-coupled receptors and ion channels, as well as other intracellular signaling molecules. In addition to holding clinical relevance, the diversity of genes selected allows for the identification of possible trends that might emerge by gene class or family between strains or sex. |
| Other Name(s): | Mouse Diversity Study |
| Parent Organization: | Resource:Allen Institute for Brain Science |
| Resource Type(s): | Database, Expression atlas |
| Keywords: | drug target, gene expression, gene regulation, gene, genetic background, adult, brain, developing, diversity, g protein-coupled receptor, ion channel, mouse, neurotransmitter, RNA in situ hybridization, sex, molecular neuroanatomy resource, In situ hybridization, male, female, C57BL/6J |
| Abbreviation: | Allen Mouse Diversity |
| Resource: | Resource |
| URL: | http://mousediversity.alleninstitute.org/ |
| Availability: | freely accessible |
| Id: | nif-0000-08695 |
| Organism: | Mouse |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Curation status: Uncurated
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This page uses this default form:Resource
| Abbrev | Allen Mouse Diversity + |
| Availability | Freely accessible + |
| CurationStatus | curated + |
| DefiningCitation | http://mousediversity.alleninstitute.org/ + |
| Definition | A database, and associated atlas, that cha … A database, and associated atlas, that characterizes gene expression across genetic backgrounds and sex, expanding beyond the adult male C57BL/6J reference brain comprising the Allen Mouse Brain Atlas to include seven strains of male mice and female C57BL/6J mice. Gene expression was detected using colorimetric RNA in situ hybridization (ISH) that provides cellular level anatomic resolution. ISH data are searchable and organized by gene, strain, or sex. This freely accessible online resource allows for simultaneous navigation and comparison of different mouse brains at high resolution, providing users with a dataset to probe for possible differences in gene regulation. For both the strain and sex components of the project, a panel of 49 well known drug target genes that are expressed in the adult and developing brain and encompass sites of action for FDA-approved drugs were assayed. These include genes encoding proteins involved in the synthesis, transport and signaling of neurotransmitters, G protein-coupled receptors and ion channels, as well as other intracellular signaling molecules. In addition to holding clinical relevance, the diversity of genes selected allows for the identification of possible trends that might emerge by gene class or family between strains or sex. across specimens were also assayed. |
| ExampleImage | |
| Has default formThis property is a special property in this wiki. | Resource + |
| Has role | Database +, and Expression atlas + |
| Id | nif-0000-08695 + |
| Is part of | Resource:Allen Institute for Brain Science + |
| Keywords | Drug target +, Gene expression +, Gene regulation +, Gene +, Genetic background +, Adult +, Brain +, Developing +, Diversity +, G protein-coupled receptor +, Ion channel +, Mouse +, Neurotransmitter +, RNA in situ hybridization +, Sex +, Molecular neuroanatomy resource +, In-situ hybridization +, Male +, Female +, C57BL/6J +, and Software resource + |
| Label | Resource:Allen Institute Mouse Diversity Study + |
| ModifiedDate | 26 April 2013 + |
| Page has default formThis property is a special property in this wiki. | Resource + |
| RelatedTo | Resource:3DVC + |
| Species | Mouse + |
| SuperCategory | Resource + |
| Synonym | Mouse Diversity Study + |



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