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Resource:Beta Cell Biology Consortium

Name: Resource:Beta Cell Biology Consortium
Description: Consortium that aims to facilitate interdisciplinary collaborations to advance the understanding of pancreatic islet development and function, with the goal of developing innovative therapies to correct the loss of beta cell mass in diabetes, including cell reprogramming, regeneration and replacement. They are responsible for collaboratively generating the necessary reagents, mouse strains, antibodies, assays, protocols, technologies and validation assays that are beyond the scope of any single research effort.

The scientific goals for the BCBC are to:

  • Use cues from pancreatic development to directly differentiate pancreatic beta cells and islets from stem / progenitor cells for use in cell-replacement therapies for diabetes,
  • Determine how to stimulate beta cell regeneration in the adult pancreas as a basis for improving beta cell mass in diabetic patients,
  • Determine how to reprogram progenitor / adult cells into pancreatic beta-cells both in-vitro and in-vivo as a mean for developing cell-replacement therapies for diabetes, and
  • Investigate the progression of human type-1 diabetes using patient-derived cells and tissues transplanted in humanized mouse models.
Many of the BCBC investigator-initiated projects involve reagent-generating activities that will benefit the larger scientific community. The combination of programs and activities should accelerate the pace of major new discoveries and progress within the field of beta cell biology.
Abbreviation: BCBC
Parent Organization: Vanderbilt University; Tennessee; USA
Supporting Agency: NIDDK
Grant: DK-01-014, DK-01-17, DK-01-18, DK-09-011
Resource Type(s): Consortium, Database, Data repository, Biospecimen repository, Cell repository, Organism supplier, Experimental protocol, Antibody supplier
Resource: Resource
URL: http://www.betacell.org/
*Id: nlx_144143
Related condition/disease: Type 2 diabetes, Type 1 diabetes, Diabetes, loss of beta cell mass
Related application: Research
Related to: Karolinska Institutet; Stockholm; Sweden, University of California at Los Angeles; California; USA, Stanford University; California; USA, University of Massachusetts Medical School; Massachusetts; USA, Hebrew University Hadassah Medical School; Jerusalem; Israel, Philipps-University Marburg; Marburg; Germany, Imperial College London; London; United Kingdom, Children's Hospital of Philadelphia; Pennsylvania; USA, Vanderbilt University Medical Center; Tennessee; USA, Icahn School of Medicine at Mount Sinai; New York; USA, University of California at San Francisco; California; USA, Massachusetts Institute of Technology; Massachusetts; USA, Hadassah Medical Center; Jerusalem; Israel, Resource:DanStem, Oregon Health and Science University; Oregon; USA, Vanderbilt University; Tennessee; USA, University of Chicago; Illinois; USA, University of Massachusetts; Massachusetts; USA, University of Colorado Boulder; Colorado; USA, Vrije Universiteit Brussel; Brussels; Belgium, University of Geneva; Geneva; Switzerland, University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA, Brigham and Womens Hospital; Massachusetts; USA, Resource:McEwen Centre for Regenerative Medicine, Seattle Childrens Research Institute; Washington; USA, Columbia University; New York; USA, Massachusetts General Hospital; Massachusetts; USA, University of Texas Southwestern Medical Center; Texas; USA, Hagedorn Research Institute; Gentofte; Denmark, Howard Hughes Medical Institute, Northwestern University; Illinois; USA, Duke University Medical Center; North Carolina; USA, CNRS, University of California at San Diego; California; USA, University of Pittsburgh; Pennsylvania; USA, University of Copenhagen; Copenhagen; Denmark, Resource:Jackson Laboratory, Max Planck Institute for Heart and Lung Research; Bad Nauheim; Germany, Cincinnati Childrens Hospital Medical Center; Ohio; USA, Indiana University; Indiana; USA, University of Toronto; Ontario; Canada, Harvard University; Massachusetts; USA, Harvard Medical School; Massachusetts; USA, Boston Childrens Hospital; Massachusetts; USA, Howard Hughes Medical Institute
Used By: Resource:NIF Data Federation, Resource:DKnet
Listed By: Resource:One Mind Biospecimen Bank Listing, US Biobank, Resource:re3data.org, Resource:Consortia-pedia
Availability: Public, The community can contribute to this resource
Address: The Beta Cell Biology Consortium, Vanderbilt Center for Stem Cell Biology, 2213 Garland Avenue, 9465 MRB IV, Nashville, TN 37232-0494 Telephone: 615.936.8327 Fax: 615.322.6645
Keywords: Pancreatic islet, Mouse, Beta cell, Pancreas, Pancreatic development, Embryonic stem cell, Cell line, Genomics, antibody, adenovirus, functional genomics, mouse Embryonic stem cell line, mouse strain, protocol, Embryonic stem cell line, data sharing, Data set, gene expression, gene, Pancreatic islet development, Pancreatic islet function, Basic science, Basic research, cell reprogramming, cell regeneration, cell replacement
Organism: Mouse, Non-human animal, Human
Link to OWL / RDF: Download this content as OWL/RDF

Categories related to Resource:Beta Cell Biology Consortium

Resource:Integrated Animals, Resource:Integrated Manually Extracted Annotation, Resource:dkCOIN

Parts of Resource:Beta Cell Biology Consortium

Curation status: Curated

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Facts about Resource:Beta Cell Biology ConsortiumRDF feed
AbbrevBCBC  +
AddressThe Beta Cell Biology Consortium  +, Vanderbilt Center for Stem Cell Biology  +, 2213 Garland Avenue  +, 9465 MRB IV  +, Nashville  +, and TN 37232-0494 Telephone: 615.936.8327 Fax: 615.322.6645  +
AvailabilityPublic  +, and The community can contribute to this resource  +
CommentSample type: Cell line, Embryonic stem cel Sample type: Cell line, Embryonic stem cell line

Access: open; Copyrights - http://www.mgtaylor.com/
Reuse: closed; Copyrights - http://www.betacell.org/content/disclaimerterms/#terms
Start date: 2002
Type: disciplinary
Deposit: restricted: registration
(info provided by re3data.org)

Type: Academia
Participant countries: U.S.
Country started: U.S.
Number of partners: 50
Start date: 2001 er of partners: 50

Start date: 2001
CurationStatuscurated  +
DefiningCitationhttp://www.betacell.org/  +
DefinitionConsortium that aims to facilitate interdi Consortium that aims to facilitate interdisciplinary collaborations to advance the understanding of pancreatic islet development and function, with the goal of developing innovative therapies to correct the loss of beta cell mass in diabetes, including cell reprogramming, regeneration and replacement. They are responsible for collaboratively generating the necessary reagents, mouse strains, antibodies, assays, protocols, technologies and validation assays that are beyond the scope of any single research effort.

The scientific goals for the BCBC are to:

  • Use cues from pancreatic development to directly differentiate pancreatic beta cells and islets from stem / progenitor cells for use in cell-replacement therapies for diabetes,
  • Determine how to stimulate beta cell regeneration in the adult pancreas as a basis for improving beta cell mass in diabetic patients,
  • Determine how to reprogram progenitor / adult cells into pancreatic beta-cells both in-vitro and in-vivo as a mean for developing cell-replacement therapies for diabetes, and
  • Investigate the progression of human type-1 diabetes using patient-derived cells and tissues transplanted in humanized mouse models.
Many of the BCBC investigator-initiated projects involve reagent-generating activities that will benefit the larger scientific community. The combination of programs and activities should accelerate the pace of major new discoveries and progress within the field of beta cell biology.
ess within the field of beta cell biology.
EditorialNoteEach of these databases should probably have their own entry, as per NIF resource curation guidelines.
ExampleImageBCBC.PNG  +
GrantCategory:DK-01-014   +, Category:DK-01-17   +, Category:DK-01-18   +, and Category:DK-09-011   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleConsortium  +, Database  +, Data repository  +, Biospecimen repository  +, Cell repository  +, Organism supplier  +, Experimental protocol  +, and Antibody supplier  +
Idnlx_144143  +
Is part ofVanderbilt University; Tennessee; USA  +
KeywordsPancreatic islet  +, Mouse  +, Beta cell  +, Pancreas  +, Pancreatic development  +, Embryonic stem cell  +, Cell line  +, Genomics  +, Antibody  +, Adenovirus  +, Functional genomics  +, Mouse Embryonic stem cell line  +, Mouse strain  +, Protocol  +, Embryonic stem cell line  +, Data sharing  +, Data set  +, Gene expression  +, Gene  +, Pancreatic islet development  +, Pancreatic islet function  +, Basic science  +, Basic research  +, Cell reprogramming  +, Cell regeneration  +, and Cell replacement  +
LabelResource:Beta Cell Biology Consortium  +
ListedbyResource:One Mind Biospecimen Bank Listing  +, US Biobank  +, Resource:re3data.org  +, and Resource:Consortia-pedia  +
ModifiedDate14 November 2014  +
Page has default formThis property is a special property in this wiki.Resource  +
RelatedToKarolinska Institutet; Stockholm; Sweden  +, University of California at Los Angeles; California; USA  +, Stanford University; California; USA  +, University of Massachusetts Medical School; Massachusetts; USA  +, Hebrew University Hadassah Medical School; Jerusalem; Israel  +, Philipps-University Marburg; Marburg; Germany  +, Imperial College London; London; United Kingdom  +, Children's Hospital of Philadelphia; Pennsylvania; USA  +, Vanderbilt University Medical Center; Tennessee; USA  +, Icahn School of Medicine at Mount Sinai; New York; USA  +, University of California at San Francisco; California; USA  +, Massachusetts Institute of Technology; Massachusetts; USA  +, Hadassah Medical Center; Jerusalem; Israel  +, Resource:DanStem  +, Oregon Health and Science University; Oregon; USA  +, Vanderbilt University; Tennessee; USA  +, University of Chicago; Illinois; USA  +, University of Massachusetts; Massachusetts; USA  +, University of Colorado Boulder; Colorado; USA  +, Vrije Universiteit Brussel; Brussels; Belgium  +, University of Geneva; Geneva; Switzerland  +, University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA  +, Brigham and Womens Hospital; Massachusetts; USA  +, Resource:McEwen Centre for Regenerative Medicine  +, Seattle Childrens Research Institute; Washington; USA  +, Columbia University; New York; USA  +, Massachusetts General Hospital; Massachusetts; USA  +, University of Texas Southwestern Medical Center; Texas; USA  +, Hagedorn Research Institute; Gentofte; Denmark  +, Howard Hughes Medical Institute  +, Northwestern University; Illinois; USA  +, Duke Medicine; North Carolina; USA  +, French National Center for Scientific Research  +, University of California at San Diego; California; USA  +, University of Pittsburgh; Pennsylvania; USA  +, University of Copenhagen; Copenhagen; Denmark  +, Resource:Jackson Laboratory  +, Max Planck Institute for Heart and Lung Research; Bad Nauheim; Germany  +, Cincinnati Childrens Hospital Medical Center; Ohio; USA  +, Indiana University; Indiana; USA  +, University of Toronto; Ontario; Canada  +, Harvard University; Massachusetts; USA  +, Harvard Medical School; Massachusetts; USA  +, and Boston Childrens Hospital; Massachusetts; USA  +
Related applicationResearch  +
Related diseaseType 2 diabetes  +, Type 1 diabetes  +, Diabetes  +, and Loss of beta cell mass  +
SpeciesMouse  +, Non-human animal  +, and Human  +
SuperCategoryResource  +
Supporting AgencyNational Institute of Diabetes and Digestive and Kidney Diseases  +
UsedbyResource:NIF Data Federation  +, and Resource:dkNET  +