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Resource:CSA - Catalytic Site Atlas

Name: Resource:CSA - Catalytic Site Atlas
Description:

The Catalytic Site Atlas (CSA) is a database documenting enzyme active sites and catalytic residues in enzymes of 3D structure. We defined a classification of catalytic residues which includes only those residues thought to be directly involved in some aspect of the reaction catalyzed by an enzyme.

The CSA contains 2 types of entry:
1. Original hand-annotated entries, derived from the primary literature. References for these entries are given.
2. Homologous entries, found by PSI-BLAST alignment (using an e value cut-off of 0.00005) to one of the original entries. The equivalent residues, which align in sequence to the catalytic residues found in the original entry are documented.

Access to the CSA is via PDB code, SWISS-PROT entry or E.C. number. Accessing via PDB code takes you straight to the CSA entry for that PDB, while accessing via SWISS-PROT or E.C. number gives a list of all PDB codes for structures assigned that particular SWISS-PROT identifier or E.C. number. Structures with entries in the CSA are given as hyperlinks.

Each CSA entry lists the catalytic residues found in that entry, using PDB residue numbering. Each site is also marked with an evidence tag, which is either "Literature reference" or "PSI-BLAST hit". If the entry is a PSI-BLAST hit you can follow the link to the original entry.

You may download the CSA.

JESS, an algorithm for constraint-based structural template matching and its application to 3D templates used by the CSA, is available for download.
Other Name(s): Catalytic Site Atlas
Parent Organization: Resource:European Bioinformatics Institute
Resource Type(s): Web accessible database, Downloadable database, Software resource
Keywords: enzyme, enzyme 3d structure, enzyme catalysis, enzyme structure, catalysis, catalytic site, catalytic residue, Gold standard or authority
Abbreviation: CSA
Resource: Resource
URL: http://www.ebi.ac.uk/thornton-srv/databases/CSA/
PMID: PMID 14681376
Id: nif-0000-02699
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Contributors

Aarnaud, Ccdbuser, Nifbot2, Zaidaziz



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Facts about Resource:CSA - Catalytic Site AtlasRDF feed
AbbrevCSA  +
CurationStatusuncurated  +
DefiningCitationhttp://www.ebi.ac.uk/thornton-srv/databases/CSA/  +
Definition

The Catalytic Site Atlas (CSA) is
The Catalytic Site Atlas (CSA) is a database documenting enzyme active sites and catalytic residues in enzymes of 3D structure. We defined a classification of catalytic residues which includes only those residues thought to be directly involved in some aspect of the reaction catalyzed by an enzyme.

The CSA contains 2 types of entry:
1. Original hand-annotated entries, derived from the primary literature. References for these entries are given.
2. Homologous entries, found by PSI-BLAST alignment (using an e value cut-off of 0.00005) to one of the original entries. The equivalent residues, which align in sequence to the catalytic residues found in the original entry are documented.

Access to the CSA is via PDB code, SWISS-PROT entry or E.C. number. Accessing via PDB code takes you straight to the CSA entry for that PDB, while accessing via SWISS-PROT or E.C. number gives a list of all PDB codes for structures assigned that particular SWISS-PROT identifier or E.C. number. Structures with entries in the CSA are given as hyperlinks.

Each CSA entry lists the catalytic residues found in that entry, using PDB residue numbering. Each site is also marked with an evidence tag, which is either "Literature reference" or "PSI-BLAST hit". If the entry is a PSI-BLAST hit you can follow the link to the original entry.

You may download the CSA.

JESS, an algorithm for constraint-based structural template matching and its application to 3D templates used by the CSA, is available for download. sed by the CSA, is available for download.
ExampleImageCatalytic Site Atlas.PNG  +
Has default formThis property is a special property in this wiki.Resource  +
Has roleWeb accessible database  +, Downloadable database  +, and Software resource  +
Idnif-0000-02699  +
Is part ofResource:European Bioinformatics Institute  +
KeywordsEnzyme  +, Enzyme 3d structure  +, Enzyme catalysis  +, Enzyme structure  +, Catalysis  +, Catalytic site  +, Catalytic residue  +, and Gold standard or authority  +
LabelResource:CSA - Catalytic Site Atlas  +
ModifiedDate14 June 2011  +
PMID14681376  +
Page has default formThis property is a special property in this wiki.Resource  +
SuperCategoryResource  +
SynonymCatalytic Site Atlas  +