arrow

From NeuroLex

Jump to: navigation, search



Resource:DART - Drug Adverse Reaction Targets

Name: Resource:DART - Drug Adverse Reaction Targets
Description: Database that provides comprehensive information about adverse effect targets of drugs described in the literature, including information about known drug adverse reaction targets, functions and properties. Moreover, proteins involved in adverse effect targets of chemicals not yet confirmed as adverse drug reaction (ADR) targets are also included as potential targets. Associated references are also included.

This database gives physiological function of each target, binding drugs / agonists / antagonists / activators / inhibitors, IC(50) values of the inhibitors, corresponding adverse effects, and type of ADR induced by drug binding to a target. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3-dimensional structure, function, and nomenclature of each target along with drug/ligand binding properties, and related literature.

Each entry can be retrieved through multiple search methods including target name, target physiological function, adverse effect, ligand name, and biological pathways.

A special page is provided for contribution of new or additional information.

Function for ADR-target prediction by SVMDART: Submit protein primary sequence for ADR-related protein prediction.[1]
Abbreviation: DART
Parent Organization: National University of Singapore; Singapore
Resource Type(s): Database, Data repository
Resource: Resource
URL: http://xin.cz3.nus.edu.sg/group/drt/dart.asp
*Id: nif-0000-02720
PMID: PMID 12862503
Availability: Non-commercial use, The community can contribute to this resource.
Address: Department of Computational Science, National University of Singapore, Blk S17, 3 Science Drive 2, Singapore 117543
Keywords: drug, drug target, evaluation, adverse drug reaction, adverse reaction, agonist, antagonist, binding, ic value, inhibitor, ligand binding property, ligand, physiological function, protein prediction, protein, protein target, target, type, toxicity, Data analysis service, toxic
Organism: Human
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

This resource will be curated within 7 days.

For Resource Owners:
After the resource is curated, you may create a sitemap, which will help keep your registry description up-to-date and inform search engines about your resource.

Note: For a new resource, the website's URL must first be verified by a NIF curator before you may proceed.

Learn more about what NIF can do for your resource.
Proudly proclaim your inclusion in NIF by displaying the "Registered with NIF" button on your site. Please login to create the sitemap. (top right)

References

  1. Ji ZL et al. (2003) Drug Adverse Reaction Target Database (DART) : proteins related to adverse drug reactions. Drug Saf 26: 685-90 PubMed

Notes

This page uses this default form:Resource

Contributors

Aarnaud, Ccdbuser, Eddy kim, Nifbot2



bookmark

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:DART - Drug Adverse Reaction TargetsRDF feed
AbbrevDART  +
AddressDepartment of Computational Science  +, National University of Singapore  +, Blk S17  +, 3 Science Drive 2  +, and Singapore 117543  +
AvailabilityNon-commercial use  +, and The community can contribute to this resource.  +
CurationStatuscurated  +
DefiningCitationhttp://xin.cz3.nus.edu.sg/group/drt/dart.asp  +
DefinitionDatabase that provides comprehensive infor Database that provides comprehensive information about adverse effect targets of drugs described in the literature, including information about known drug adverse reaction targets, functions and properties. Moreover, proteins involved in adverse effect targets of chemicals not yet confirmed as adverse drug reaction (ADR) targets are also included as potential targets. Associated references are also included.

This database gives physiological function of each target, binding drugs / agonists / antagonists / activators / inhibitors, IC(50) values of the inhibitors, corresponding adverse effects, and type of ADR induced by drug binding to a target. Cross-links to other databases are also introduced to facilitate the access of information about the sequence, 3-dimensional structure, function, and nomenclature of each target along with drug/ligand binding properties, and related literature.

Each entry can be retrieved through multiple search methods including target name, target physiological function, adverse effect, ligand name, and biological pathways.

A special page is provided for contribution of new or additional information.

Function for ADR-target prediction by SVMDART: Submit protein primary sequence for ADR-related protein prediction.
quence for ADR-related protein prediction.
ExampleImageDART.PNG  +
Has default formThis property is a special property in this wiki.Resource  +
Has roleDatabase  +, and Data repository  +
Idnif-0000-02720  +
Is part ofNational University of Singapore; Singapore  +
KeywordsDrug  +, Drug target  +, Evaluation  +, Adverse drug reaction  +, Adverse reaction  +, Agonist  +, Antagonist  +, Binding  +, Ic value  +, Inhibitor  +, Ligand binding property  +, Ligand  +, Physiological function  +, Protein prediction  +, Protein  +, Protein target  +, Target  +, Type  +, Toxicity  +, Data analysis service  +, and Toxic  +
LabelResource:DART - Drug Adverse Reaction Targets  +
ModifiedDate30 May 2013  +
PMID12862503  +
Page has default formThis property is a special property in this wiki.Resource  +
SpeciesHuman  +
SuperCategoryResource  +