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Resource:DIAN - Dominantly Inherited Alzheimer Network

Name: Resource:DIAN - Dominantly Inherited Alzheimer Network
Description: An international research partnership of leading scientists determined to understand a rare form of Alzheimer’s disease that is caused by a gene mutation and to establish a research database and tissue repository to support research on Alzheimer's disease by other investigators around the world.

Understanding of this form of Alzheimer's disease may provide clues to decoding other dementias and developing dementia treatments. DIAN is currently enrolling study participants who are biological adult children of a parent with a mutated gene known to cause dominantly inherited Alzheimer’s disease. Such individuals may or may not carry the gene themselves and may or may not have disease symptoms.

Research suggests that certain brain changes occur years before actual Alzheimer’s symptoms are detected. One goal of DIAN is to study these possible changes in people who carry an Alzheimer’s disease mutation. Other family members without a mutation will serve as a comparison group.

People in families in which a mutation has been identified will be tracked in order to detect physical or mental changes that might distinguish people who inherited the mutation from those who did not. A list of procedures that participants may be involved in include:

  • Clinical assessment
  • Memory and thinking tests
  • Blood draw
  • Cerebral spinal fluid sample testing and banking
  • Brain magnetic resonance imaging (MRI)
  • Brain fluorodeoxyglucose positron emission tomography (FDG PET)
  • Brain positron emission tomography using Pittsburgh Compound-B (PET-PIB)
  • Brain autopsy in case of death

Participants will have the procedures at the time of enrollment into DIAN and thereafter every one to three years, depending on the participant’s age and the age at which his or her family member began to show signs of Alzheimer’s disease.

DIAN currently involves eleven outstanding research institutions in the United States, United Kingdom, and Australia. John C. Morris, M.D., Friedman Distinguished Professor of Neurology at Washington University School of Medicine in St. Louis, is the project’s principal investigator.
Other Name(s): Dominantly Inherited Alzheimer Network, Dominantly Inherited Alzheimer Network (DIAN)
Abbreviation: DIAN
Parent Organization: Washington University School of Medicine in St. Louis; Missouri; USA
Supporting Agency: NIA
Grant: U01AG032438
Resource Type(s): Disease-related portal, Biomaterial supply resource, Brain bank, Database
Resource: Resource
URL: http://www.dian-info.org/default.htm
*Id: nlx_149316
Publication link: http://www.dian-info.org/pdfs/Brochure.pdf
Related condition/disease: Dominantly inherited Alzheimer's disease, Biological adult child of a parent with a mutated gene known to cause dominantly inherited Alzheimer's disease, Alzheimer's disease, Normal control, Aging
Related application: Research
Processing: Formalin-fixed, Paraffin wax embedded, Block, Frozen
Related to: Resource:National Cell Repository for Alzheimers Disease
Listed By: Resource:One Mind Biospecimen Bank Listing, US Biobank
Availability: Approval required, DIAN data sharing policy
Keywords: gene mutation, dementia, cerebrum, Image, Middle frontal gyrus, Superior temporal gyri, middle temporal gyri, Inferior parietal lobe, angular gyrus, Occipital lobe, calcarine sulcus, peristriate cortex, Anterior cingulate gyrus, genu of the corpus callosum, Posterior cingulate gyrus, precuneus, splenium, Amygdala, entorhinal cortex, Hippocampus, parahippocampal gyrus, Striatum, caudate nucleus, anterior commissure, Lentiform nuclei, globus pallidus, putamen, Thalamus, subthalamic nucleus, Midbrain, Pons, Medulla oblongata, Cerebellum, dentate nucleus, Spinal cord, Frontal lobe, temporal lobe, mamillary body, parietal lobe, lateral geniculate nucleus, Occipital lobe, calcarine sulcus, Cerebellar hemisphere, dentate nucleus, Clinical Dementia Rating, Geriatric Depression Scale, Functional Assessment Questionnaire, Neuropsychiatric Inventory-Q, United Parkinsons Disease Rating Scale (UPDRS)-Motor, Hachinski Ischemic Score, Cerebrovascular Risk Factor, Cerebral Spinal Fluid, Plasma, Serum, Blood, Brain tissue, Brain, Tissue, Formalin-fixed, Paraffin wax embedded, Block, Frozen, Clinical data, Clinical, Demographics, Psychometrics, APOE Genotype, Adult human, MRI, Positron emission tomography, Clinical assessment, psychometric testing
Organism: Human
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Curated

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Notes

This page uses this default form:Resource

Contributors

Aarnaud, Ccdbuser, Hiliao, Memartone



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:DIAN - Dominantly Inherited Alzheimer NetworkRDF feed
AbbrevDIAN  +
AvailabilityApproval required  +, and DIAN data sharing policy  +
CommentSample type: Cerebral Spinal Fluid, Plasma, Serum, Blood, Brain tissue, Brain, Tissue
CurationStatusuncurated  +
DefiningCitationhttp://www.dian-info.org/default.htm  +
DefinitionAn international research partnership of l An international research partnership of leading scientists determined to understand a rare form of Alzheimer’s disease that is caused by a gene mutation and to establish a research database and tissue repository to support research on Alzheimer's disease by other investigators around the world.

Understanding of this form of Alzheimer's disease may provide clues to decoding other dementias and developing dementia treatments. DIAN is currently enrolling study participants who are biological adult children of a parent with a mutated gene known to cause dominantly inherited Alzheimer’s disease. Such individuals may or may not carry the gene themselves and may or may not have disease symptoms.

Research suggests that certain brain changes occur years before actual Alzheimer’s symptoms are detected. One goal of DIAN is to study these possible changes in people who carry an Alzheimer’s disease mutation. Other family members without a mutation will serve as a comparison group.

People in families in which a mutation has been identified will be tracked in order to detect physical or mental changes that might distinguish people who inherited the mutation from those who did not. A list of procedures that participants may be involved in include:

  • Clinical assessment
  • Memory and thinking tests
  • Blood draw
  • Cerebral spinal fluid sample testing and banking
  • Brain magnetic resonance imaging (MRI)
  • Brain fluorodeoxyglucose positron emission tomography (FDG PET)
  • Brain positron emission tomography using Pittsburgh Compound-B (PET-PIB)
  • Brain autopsy in case of death

Participants will have the procedures at the time of enrollment into DIAN and thereafter every one to three years, depending on the participant’s age and the age at which his or her family member began to show signs of Alzheimer’s disease.

DIAN currently involves eleven outstanding research institutions in the United States, United Kingdom, and Australia. John C. Morris, M.D., Friedman Distinguished Professor of Neurology at Washington University School of Medicine in St. Louis, is the project’s principal investigator.
, is the project’s principal investigator.
ExampleImageDIAN.PNG  +, and File:Rare disease  +
GrantCategory:U01AG032438   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleDisease-related portal  +, Biomaterial supply resource  +, Brain bank  +, and Database  +
Idnlx_149316  +
Is part ofWashington University School of Medicine in St. Louis; Missouri; USA  +
KeywordsGene mutation  +, Dementia  +, Cerebrum  +, Image  +, Middle frontal gyrus  +, Superior temporal gyri  +, Middle temporal gyri  +, Inferior parietal lobe  +, Angular gyrus  +, Occipital lobe  +, Calcarine sulcus  +, Peristriate cortex  +, Anterior cingulate gyrus  +, Genu of the corpus callosum  +, Posterior cingulate gyrus  +, Precuneus  +, Splenium  +, Amygdala  +, Entorhinal cortex  +, Hippocampus  +, Parahippocampal gyrus  +, Striatum  +, Caudate nucleus  +, Anterior commissure  +, Lentiform nuclei  +, Globus pallidus  +, Putamen  +, Thalamus  +, Subthalamic nucleus  +, Midbrain  +, Pons  +, Medulla oblongata  +, Cerebellum  +, Dentate nucleus  +, Spinal cord  +, Frontal lobe  +, Temporal lobe  +, Mamillary body  +, Parietal lobe  +, Lateral geniculate nucleus  +, Cerebellar hemisphere  +, Clinical Dementia Rating  +, Geriatric Depression Scale  +, Functional Assessment Questionnaire  +, Neuropsychiatric Inventory-Q  +, United Parkinsons Disease Rating Scale (UPDRS)-Motor  +, Hachinski Ischemic Score  +, Cerebrovascular Risk Factor  +, Cerebral Spinal Fluid  +, Plasma  +, Serum  +, Blood  +, Brain tissue  +, Brain  +, Tissue  +, Formalin-fixed  +, Paraffin wax embedded  +, Block  +, Frozen  +, Clinical data  +, Clinical  +, Demographics  +, Psychometrics  +, APOE Genotype  +, Adult human  +, MRI  +, Positron emission tomography  +, Clinical assessment  +, and Psychometric testing  +
LabelResource:DIAN - Dominantly Inherited Alzheimer Network  +
ListedbyResource:One Mind Biospecimen Bank Listing  +, and US Biobank  +
ModifiedDate26 August 2014  +
Page has default formThis property is a special property in this wiki.Resource  +
ProcessingFormalin-fixed  +, Paraffin wax embedded  +, Block  +, and Frozen  +
PublicationLinkhttp://www.dian-info.org/pdfs/Brochure.pdf  +
RelatedToResource:National Cell Repository for Alzheimers Disease  +
Related applicationResearch  +
Related diseaseDominantly inherited Alzheimer's disease  +, Biological adult child of a parent with a mutated gene known to cause dominantly inherited Alzheimer's disease  +, Alzheimer's disease  +, Normal control  +, and Aging  +
SpeciesHuman  +
SuperCategoryResource  +
Supporting AgencyNIA  +
SynonymDominantly Inherited Alzheimer Network  +, and Dominantly Inherited Alzheimer Network (DIAN)  +