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Resource:Development of a Specific-Pathogen-Free Baboon Colony

Name: Resource:Development of a Specific-Pathogen-Free Baboon Colony
Description: Program developing a self-sustaining colony of baboons free of all known herpesviruses, four retroviruses, and SV40 for research. When the program is fully developed, they will provide healthy, behaviorally normal, SPF baboons that are free of all known herpes viruses, four retroviruses, and SV40. To accomplish this goal, the center has established in collaboration with co-investigators and consultants serological and PCR tests for each of the 11 target viruses. These baboon viruses include six herpesviruses (analogs of human HSV, VZV, CMV, HHV6, EBV, and HHV8), four retroviruses (simian foamy virus, SRV/D, SIV, and STLV), and SV40. Twenty-four infant baboons are being recruited into the SPF program in each of the first five years, for a final total of at least 66 SPF baboons. All infants will be repeatedly tested for each of the target viruses. At one month of age, larger social groups of 4-6 SPF animals are formed. Beginning at 2-3 years of age, SPF animals will be integrated into larger socially compatible groups. These groups will eventually mature into breeding harems of SPF animals. This approach provides infants with age-matched companions for socialization during their early period of development, minimizes opportunities for transmission of viruses to the infants from adult animals, and allows for the simultaneous elimination of many different viruses from SPF animals.
Abbreviation: Development of a SPF Baboon Colony
Parent Organization: University of Oklahoma; Oklahoma; USA
Supporting Agency: NCRR
Grant: R24 RR016556
Resource Type(s): Biomaterial manufacture, Organism supplier
Resource: Resource
URL: http://www.ouhsc.edu/compmed/documents/DevelopmentofaSpecificPathogenFreeBaboonColony.pdf
Id: nif-0000-25871
Address: Development of a Specific-Pathogen-Free Baboon Colony, Comparative Medicine, University of Oklahoma Health Sciences Center, 940 S. L. Young Boulevard; BMSB 203, Oklahoma City, OK 73190
Keywords: baboon, herpes virus, human, macaque, pathogen, primate, retrovirus, virus
Organism: Baboon
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Curated

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Notes

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Old URL: http://www.ncrr.nih.gov/comparative_medicine/resource_directory/primates.asp

Contributors

Aarnaud, Akash, Ccdbuser, Nifbot2



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Facts about Resource:Development of a Specific-Pathogen-Free Baboon ColonyRDF feed
AbbrevDevelopment of a SPF Baboon Colony  +
AddressDevelopment of a Specific-Pathogen-Free Baboon Colony  +, Comparative Medicine  +, University of Oklahoma Health Sciences Center  +, 940 S. L. Young Boulevard; BMSB 203  +, Oklahoma City  +, and OK 73190  +
CurationStatuscurated  +
DefiningCitationhttp://www.ouhsc.edu/compmed/documents/DevelopmentofaSpecificPathogenFreeBaboonColony.pdf  +
DefinitionProgram developing a self-sustaining colon Program developing a self-sustaining colony of baboons free of all known herpesviruses, four retroviruses, and SV40 for research. When the program is fully developed, they will provide healthy, behaviorally normal, SPF baboons that are free of all known herpes viruses, four retroviruses, and SV40. To accomplish this goal, the center has established in collaboration with co-investigators and consultants serological and PCR tests for each of the 11 target viruses. These baboon viruses include six herpesviruses (analogs of human HSV, VZV, CMV, HHV6, EBV, and HHV8), four retroviruses (simian foamy virus, SRV/D, SIV, and STLV), and SV40. Twenty-four infant baboons are being recruited into the SPF program in each of the first five years, for a final total of at least 66 SPF baboons. All infants will be repeatedly tested for each of the target viruses. At one month of age, larger social groups of 4-6 SPF animals are formed. Beginning at 2-3 years of age, SPF animals will be integrated into larger socially compatible groups. These groups will eventually mature into breeding harems of SPF animals. This approach provides infants with age-matched companions for socialization during their early period of development, minimizes opportunities for transmission of viruses to the infants from adult animals, and allows for the simultaneous elimination of many different viruses from SPF animals. f many different viruses from SPF animals.
GrantCategory:R24 RR016556   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleBiomaterial manufacture  +, and Organism supplier  +
Idnif-0000-25871  +
Is part ofUniversity of Oklahoma; Oklahoma; USA  +
KeywordsBaboon  +, Herpes virus  +, Human  +, Macaque  +, Pathogen  +, Primate  +, Retrovirus  +, and Virus  +
LabelResource:Development of a Specific-Pathogen-Free Baboon Colony  +
ModifiedDate31 October 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
SpeciesBaboon  +
SuperCategoryResource  +
Supporting AgencyNCRR  +