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Resource:EONS-The integrated synaptic modeling platform

Name: Resource:EONS-The integrated synaptic modeling platform
Description: EONS is a tool to study the interactions between synaptic elements. There are several versions for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.
EONS v2.0 is a much more flexible platform. The user can specify the equations that drive the models, as well as the geometry of the synapse (complex 2D geometry based on real electromicrograph pictures). This platform requires much more advanced modeling experience. See the tutorial for more information.
Our research focus consists in modeling hippocampal synaptic nonlinear dynamics and understanding their challenging complexity. Such modeling consists in understanding the role of the elements that comprise a synapse and participate in the transmission of information from the presynaptic terminal to post-synaptic density and more generally from a neuron to another. This also involves understanding the different interactions that exist between these elements and how geometry affects synaptic response.
Our research is done through a modeling platform called EONS (Elementary Objects of the Nervous System). This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more.
The EONS modeling platforms are developed at the Laboratory of Neural Engineering of the University of Southern California under the supervision of Prof. Theodore W. Berger and Dr. Jean-Marie C. Bouteiller.
modeling, synapse, presynaptic terminal, post-synaptic density, neuron, modeling platform, graphical interface, graphical interface, synaptic geometry, behavior, 2D rectangular geometry, distribution hypotheses, presynaptic, postsynaptic, electromicrograph, Contour Generator, Differential Equation Generator, Java Virtual Machine, Web Start Applications, kinetic equations, design, jpeg, gif, contours, platform independent, animation, simulation, Presynaptic elements, Calcium channels, Localized calcium buffers, Diffuse calcium buffers, Calcium diffusion modeling, Calcium pumps, vesicular kinetics, Synaptic cleft, Postsynaptic elements, AMPA receptors, NMDA receptors, Simulated excitatory postsynaptic potential, Slow and medium potassium channels, Metabotropic glutamate receptors, Endoplasmic Reticulum (ER), ER calcium ATPase, ER IP3 receptors, Calcium channels, Sodium/calcium exchanger,
Other Name(s): EONS
Parent Organization: USC: Laboratories of Prof. Theodore W. Berger and Dr. Jean-Marie C. Bouteiller
Resource Type(s): simulation software
Resource: Resource
URL: http://www.synaptic-modeling.com
Id: nif-0000-00504
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Curated

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Retrieved from "http://neurolex.org/wiki/Category:Resource:EONS-The_integrated_synaptic_modeling_platform"
Facts about Resource:EONS-The integrated synaptic modeling platformRDF feed
DefiningCitationhttp://www.synaptic-modeling.com  +
DefinitionEONS is a tool to study the interactions b … EONS is a tool to study the interactions between synaptic elements. There are several versions for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.
EONS v2.0 is a much more flexible platform. The user can specify the equations that drive the models, as well as the geometry of the synapse (complex 2D geometry based on real electromicrograph pictures). This platform requires much more advanced modeling experience. See the tutorial for more information.
Our research focus consists in modeling hippocampal synaptic nonlinear dynamics and understanding their challenging complexity. Such modeling consists in understanding the role of the elements that comprise a synapse and participate in the transmission of information from the presynaptic terminal to post-synaptic density and more generally from a neuron to another. This also involves understanding the different interactions that exist between these elements and how geometry affects synaptic response.
Our research is done through a modeling platform called EONS (Elementary Objects of the Nervous System). This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more.
The EONS modeling platforms are developed at the Laboratory of Neural Engineering of the University of Southern California under the supervision of Prof. Theodore W. Berger and Dr. Jean-Marie C. Bouteiller.
modeling, synapse, presynaptic terminal, post-synaptic density, neuron, modeling platform, graphical interface, graphical interface, synaptic geometry, behavior, 2D rectangular geometry, distribution hypotheses, presynaptic, postsynaptic, electromicrograph, Contour Generator, Differential Equation Generator, Java Virtual Machine, Web Start Applications, kinetic equations, design, jpeg, gif, contours, platform independent, animation, simulation, Presynaptic elements, Calcium channels, Localized calcium buffers, Diffuse calcium buffers, Calcium diffusion modeling, Calcium pumps, vesicular kinetics, Synaptic cleft, Postsynaptic elements, AMPA receptors, NMDA receptors, Simulated excitatory postsynaptic potential, Slow and medium potassium channels, Metabotropic glutamate receptors, Endoplasmic Reticulum (ER), ER calcium ATPase, ER IP3 receptors, Calcium channels, Sodium/calcium exchanger,
nels, Sodium/calcium exchanger,
Has default formThis property is a special property in this wiki.Resource  +
Has roleSimulation software  +
Idnif-0000-00504  +
Is part ofUSC: Laboratories of Prof. Theodore W. Berger and Dr. Jean-Marie C. Bouteiller  +
LabelResource:EONS-The integrated synaptic modeling platform  +
ModifiedDate13 October 2010  +
SuperCategoryResource  +
SynonymEONS  +