arrow

From NeuroLex

Jump to: navigation, search



Resource:EONS

Name: Resource:EONS
Description: Modeling platform to study the basic interactions between synaptic elements that allows the user to study qualitatively, and also quantitatively the relative contributions of diverse mechanisms underlying synaptic efficacy: the relevance of each and every element that comprises a synapse, the interactions between these components and their subcellular distribution, as well as the influence of synaptic geometry (presynaptic terminal, cleft and postsynaptic density).

This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more.

EONS is a parametric model of a generic glutamatergic synapse that takes into account pre-synaptic mechanisms, such as calcium buffering and diffusion, neurotransmitter release, diffusion and uptake in the cleft, and postsynaptic elements, such as ionotropic AMPA and NMDA receptors, their distribution and synaptic geometry, as well as metabotropic glutamate receptors.

There are no complicated equations to write: all the models are predefined. This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.

System Requirements: EONS V1.2 is a Windows program but can be also successfully installed and run on Mac and Linux.[1]
Other Name(s): Elementary Objects of the Nervous System, EONS (Elementary Objects of the Nervous System), EONS-The integrated synaptic modeling platform
Parent Organization: Resource:Biomedical Simulations Resource
Supporting Agency: NIBIB
Related to: Resource:NITRC
Resource Type(s): Simulation software
Keywords: synapse, geometry, distribution hypothesis, 2D, synaptic modeling, synaptic, modeling, neuron, nervous system, presynaptic, postsynaptic, electromicrograph, animation, simulation, Calcium channel, Synaptic cleft, excitatory postsynaptic potential, Potassium channel, Computational neuroscience, Java, MacOS, Microsoft, Windows, Windows XP
Grant: P41-EB001978
Abbreviation: EONS
Resource: Resource
URL: http://bmsr.usc.edu/software/eons/
PMID: PMID 17946227
Availability: Free, Non-commercial
Address: Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA 90089-1111, USA.
Id: nif-0000-00504
Organism: Human
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Curated

For Resource Owners:

A sitemap will keep your NIF Registry description up-to-date and inform search engines about your resource.

Please login to create the sitemap. (top right)

Learn more about what NIF can do for your resource.
Proudly proclaim your inclusion in NIF by displaying the "Registered with NIF" button on your site.

References

  1. Bouteiller JM et al. (2006) EONS: an online synaptic modeling platform. Conf Proc IEEE Eng Med Biol Soc 1: 4155-8 PubMed

Notes

This page uses this default form:Resource

Old URL: http://www.synaptic-modeling.com
Alt. URL: http://synapticmodeling.com/
Alt. NITRC URL: http://www.nitrc.org/projects/eons

Contributors

Aarnaud



bookmark
Facts about Resource:EONSRDF feed
AbbrevEONS  +
AddressDept. of Biomed. Eng.  +, Univ. of Southern California  +, Los Angeles  +, CA 90089-1111  +, and USA.  +
AvailabilityFree  +, and Non-commercial  +
CurationStatuscurated  +
DefiningCitationhttp://bmsr.usc.edu/software/eons/  +
DefinitionModeling platform to study the basic inter Modeling platform to study the basic interactions between synaptic elements that allows the user to study qualitatively, and also quantitatively the relative contributions of diverse mechanisms underlying synaptic efficacy: the relevance of each and every element that comprises a synapse, the interactions between these components and their subcellular distribution, as well as the influence of synaptic geometry (presynaptic terminal, cleft and postsynaptic density).

This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more.

EONS is a parametric model of a generic glutamatergic synapse that takes into account pre-synaptic mechanisms, such as calcium buffering and diffusion, neurotransmitter release, diffusion and uptake in the cleft, and postsynaptic elements, such as ionotropic AMPA and NMDA receptors, their distribution and synaptic geometry, as well as metabotropic glutamate receptors.

There are no complicated equations to write: all the models are predefined. This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.

System Requirements: EONS V1.2 is a Windows program but can be also successfully installed and run on Mac and Linux.
sfully installed and run on Mac and Linux.
ExampleImageEONS.PNG  +
GrantCategory:P41-EB001978   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleSimulation software  +
Idnif-0000-00504  +
Is part ofResource:Biomedical Simulations Resource  +
KeywordsSynapse  +, Geometry  +, Distribution hypothesis  +, 2D  +, Synaptic modeling  +, Synaptic  +, Modeling  +, Neuron  +, Nervous system  +, Presynaptic  +, Postsynaptic  +, Electromicrograph  +, Animation  +, Simulation  +, Calcium channel  +, Synaptic cleft  +, Excitatory postsynaptic potential  +, Potassium channel  +, Computational neuroscience  +, Java  +, MacOS  +, Microsoft  +, Windows  +, and Windows XP  +
LabelResource:EONS  +
ModifiedDate4 November 2013  +
PMID17946227  +
Page has default formThis property is a special property in this wiki.Resource  +
RelatedToResource:NITRC  +
SpeciesHuman  +
SuperCategoryResource  +
Supporting AgencyNIBIB  +
SynonymElementary Objects of the Nervous System  +, EONS (Elementary Objects of the Nervous System)  +, and EONS-The integrated synaptic modeling platform  +