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Resource:Gene3D
| Name: | Resource:Gene3D |
| Description: | A large database of CATH protein domain assignments for ENSEMBL genomes and Uniprot sequences. Gene3D is a resource of form studying proteins and the component domains. Gene3D takes the HMM's derived from CATH families and scans them against various sequence databases. By doing this transfer of structural annotation we are able to extend the structural annotation from 1000's of structures to millions of sequences. Strict confidence cut-offs are used to ensure the reliability of the domain assignments. Other external resources are imported into Gene3D to provide complimentary information. Gene3D imports functional information from sources such as UNIPROT, and KEGG. They also import experimental datasets on request to help researchers integrate there data with the corpus of the literature. The website allows users to view descriptions for both single proteins and genes and large protein sets, such as superfamilies or genomes. Subsets can then be selected for detailed investigation or associated functions and interactions can be used to expand explorations to new proteins. The Gene3D web services provide programmatic access to the CATH-Gene3D annotation resources and in-house software tools. These services include Gene3DScan for identifying structural domains within protein sequences, access to pre-calculated annotations for the major sequence databases, and linked functional annotation from UniProt, GO and KEGG. |
| Other Name(s): | Gene3D - Structures assigned to Genomes |
| Parent Organization: | University College London; London; United Kingdom |
| Supporting Agency: | Wellcome Trust, European Commission, (Framework Program 6), National Institutes of Health, ENFIN |
| Resource Type(s): | Web accessible database, Downloadable database, Web service, Data storage repository |
| Keywords: | protein domain, protein, protein superfamily, hidden Markov model, structural domain, genome, sequence, Domain assignments |
| Grant: | LSHG-CT-2003-503265, LSHG-CT-2004-512092, DE-AC02-065CH11357, LSHG-CT-2005-518254 |
| Abbreviation: | Gene3D |
| Resource: | Resource |
| URL: | http://gene3d.biochem.ucl.ac.uk/Gene3D/ |
| PMID: | PMID 19906693, 18032434 |
| Id: | nif-0000-02877 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Curation status: Uncurated
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Notes
This page uses this default form:Resource
| Abbrev | Gene3D + |
| CurationStatus | uncurated + |
| DefiningCitation | http://gene3d.biochem.ucl.ac.uk/Gene3D/ + |
| Definition | A large database of CATH protein domain as … A large database of CATH protein domain assignments for ENSEMBL genomes and Uniprot sequences. Gene3D is a resource of form studying proteins and the component domains. Gene3D takes the HMM's derived from CATH families and scans them against various sequence databases. By doing this transfer of structural annotation we are able to extend the structural annotation from 1000's of structures to millions of sequences. Strict confidence cut-offs are used to ensure the reliability of the domain assignments. Other external resources are imported into Gene3D to provide complimentary information. Gene3D imports functional information from sources such as UNIPROT, and KEGG. They also import experimental datasets on request to help researchers integrate there data with the corpus of the literature. The website allows users to view descriptions for both single proteins and genes and large protein sets, such as superfamilies or genomes. Subsets can then be selected for detailed investigation or associated functions and interactions can be used to expand explorations to new proteins. The Gene3D web services provide programmatic access to the CATH-Gene3D annotation resources and in-house software tools. These services include Gene3DScan for identifying structural domains within protein sequences, access to pre-calculated annotations for the major sequence databases, and linked functional annotation from UniProt, GO and KEGG. onal annotation from UniProt, GO and KEGG. |
| ExampleImage |  + |
| Grant | Category:LSHG-CT-2003-503265 +, Category:LSHG-CT-2004-512092 +, Category:DE-AC02-065CH11357 +, and Category:LSHG-CT-2005-518254 + |
| Has default formThis property is a special property in this wiki. | Resource + |
| Has role | Web accessible database +, Downloadable database +, Web service +, and Data storage repository + |
| Id | nif-0000-02877 + |
| Is part of | University College London; London; United Kingdom + |
| Keywords | Protein domain +, Protein +, Protein superfamily +, Hidden Markov model +, Structural domain +, Genome +, Sequence +, and Domain assignments + |
| Label | Resource:Gene3D + |
| ModifiedDate | 6 March 2013 + |
| PMID | 19906693, 18032434 + |
| Page has default formThis property is a special property in this wiki. | Resource + |
| SuperCategory | Resource + |
| Supporting Agency | Wellcome Trust +, European Commission +, (Framework Program 6) +, National Institutes of Health +, and ENFIN + |
| Synonym | Gene3D - Structures assigned to Genomes + |
