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Resource:Genes to Cognition: Neuroscience Research Programme

Name: Resource:Genes to Cognition: Neuroscience Research Programme
Description: A neuroscience research program that studies genes, the brain and behavior in an integrated manner, established to elucidate the molecular mechanisms of learning and memory, and shed light on the pathogenesis of disorders of cognition.

Central to G2C investigations is the NMDA receptor complex (NRC/MASC), that is found at the synapses in the central nervous system which constitute the functional connections between neurons. Changes in the receptor and associated components are thought to be in a large part responsible for the phenomenon of synaptic plasticity, that may underlie learning and memory.

G2C is addressing the function of synapse proteins using large scale approaches combining genomics, proteomics and genetic methods with electrophysiological and behavioral studies. This is incorporated with computational models of the organization of molecular networks at the synapse. These combined approaches provide a powerful and unique opportunity to understand the mechanisms of disease genes in behavior and brain pathology as well as provide fundamental insights into the complexity of the human brain.

Additionally, Genes to Cognition makes available its biological resources, including gene-targeting vectors, ES cell lines, antibodies, and transgenic mice, generated for its phenotyping pipeline. The resources are freely-available to interested researchers.
Other Name(s): G2C, Genes to Cognition, Genes to Cognition - Neuroscience Research Programme, Genes to Cognition-Neuroscience Research Programme, Genes to Cognition: Neuroscience Research Program, G2C Neuroscience Research Program, G2C Research Program, G2C Research Programme
Parent Organization: Wellcome Trust Sanger Institute; Hinxton; United Kingdom
Supporting Agency: Wellcome Trust, MRC, BBSRC, Resource:Gatsby Charitable Foundation, Human Frontiers Science Programme, European Union, (Framework Programme), EPSRC, NSF
Resource Type(s): Topical portal
Resource: Resource
URL: http://www.genes2cognition.org/
*Id: nif-0000-10235
Related to: Resource:3DVC
Keywords: electrophysiological, es cell, functional, gene, gene-target vector, genetic, 1295s, allele, antibody, behavior, behavioral, brain, c57bl/6j, central nervous system, clone, cognition, computation, connection, deletion, disease, disorder, dlg3, dlg4, domain, genomic, guanylate kinase, hprt gene, hras1, human, knockout, learning, mechanism, memory, model, molecular, mouse, mutation, network, neuron, neuroscience, nmda receptor complex, pathogenesis, phenotyping, protein, proteomics, ptk2, strain, synapse, synaptic plasticity, syngap1, transgenic, Model
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Parts of Resource:Genes to Cognition: Neuroscience Research Programme

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Contributors

Aarnaud, Akash, Ccdbuser, Nifbot2, Yazin



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:Genes to Cognition: Neuroscience Research ProgrammeRDF feed
CurationStatuscurated  +
DefiningCitationhttp://www.genes2cognition.org/  +
DefinitionA neuroscience research program that studi A neuroscience research program that studies genes, the brain and behavior in an integrated manner, established to elucidate the molecular mechanisms of learning and memory, and shed light on the pathogenesis of disorders of cognition.

Central to G2C investigations is the NMDA receptor complex (NRC/MASC), that is found at the synapses in the central nervous system which constitute the functional connections between neurons. Changes in the receptor and associated components are thought to be in a large part responsible for the phenomenon of synaptic plasticity, that may underlie learning and memory.

G2C is addressing the function of synapse proteins using large scale approaches combining genomics, proteomics and genetic methods with electrophysiological and behavioral studies. This is incorporated with computational models of the organization of molecular networks at the synapse. These combined approaches provide a powerful and unique opportunity to understand the mechanisms of disease genes in behavior and brain pathology as well as provide fundamental insights into the complexity of the human brain.

Additionally, Genes to Cognition makes available its biological resources, including gene-targeting vectors, ES cell lines, antibodies, and transgenic mice, generated for its phenotyping pipeline. The resources are freely-available to interested researchers.
available to interested researchers.
Has default formThis property is a special property in this wiki.Resource  +
Has roleTopical portal  +
Idnif-0000-10235  +
Is part ofWellcome Trust Sanger Institute; Hinxton; United Kingdom  +
KeywordsElectrophysiological  +, Es cell  +, Functional  +, Gene  +, Gene-target vector  +, Genetic  +, 1295s  +, Allele  +, Antibody  +, Behavior  +, Behavioral  +, Brain  +, C57bl/6j  +, Central nervous system  +, Clone  +, Cognition  +, Computation  +, Connection  +, Deletion  +, Disease  +, Disorder  +, Dlg3  +, Dlg4  +, Domain  +, Genomic  +, Guanylate kinase  +, Hprt gene  +, Hras1  +, Human  +, Knockout  +, Learning  +, Mechanism  +, Memory  +, Model  +, Molecular  +, Mouse  +, Mutation  +, Network  +, Neuron  +, Neuroscience  +, Nmda receptor complex  +, Pathogenesis  +, Phenotyping  +, Protein  +, Proteomics  +, Ptk2  +, Strain  +, Synapse  +, Synaptic plasticity  +, Syngap1  +, and Transgenic  +
LabelResource:Genes to Cognition: Neuroscience Research Programme  +
ModifiedDate25 March 2014  +
Page has default formThis property is a special property in this wiki.Resource  +
RelatedToResource:3DVC  +
SuperCategoryResource  +
Supporting AgencyWellcome Trust  +, MRC  +, BBSRC  +, Resource:Gatsby Charitable Foundation  +, Human Frontiers Science Programme  +, European Union  +, (Framework Programme)  +, EPSRC  +, and NSF  +
SynonymG2C  +, Genes to Cognition  +, Genes to Cognition - Neuroscience Research Programme  +, Genes to Cognition-Neuroscience Research Programme  +, Genes to Cognition: Neuroscience Research Program  +, G2C Neuroscience Research Program  +, G2C Research Program  +, and G2C Research Programme  +