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Resource:Human Potential Tumor Associated Antigen database

Name: Resource:Human Potential Tumor Associated Antigen database
Description: To accelerate the process of tumor antigen discovery, we generated a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with pTAAs identified by insilico computing. 3518 potential targets have been included in the database, which is freely available to academic users. It successfully screened out 41 of 82 known Cancer-Testis antigens, 6 of 18 differentiation antigen, 2 of 2 oncofetal antigen, and 7 of 12 FDA approved cancer markers that have Gene ID, therefore will provide a good platform for identification of cancer target genes.

This database utilizes expression data from various expression platforms, including carefully chosen publicly available microarray expression data, GEO SAGE data, Unigene expression data. In addition, other relevant databases required for TAA discovery such as CGAP, CCDS, gene ontology database etc, were also incorporated.

In order to integrate different expression platforms together, various strategies and algorithms have been developed. Known tumor antigens are gathered from literature and serve as training sets. A total tumor specificity penalty was computed from positive clue penalty for differential expression in human cancers, the corresponding differential ratio, and normal tissue restriction penalty for each gene.

We hope this database will help with the process of cancer immunome identification, thus help with improving the diagnosis and treatment of human carcinomas.


Other Name(s): HPtaa Database
Parent Organization: Chinese Academy of Sciences; Beijing; China
Supporting Agency: National 863 program in China, National Natural Science Foundation of China, Ludwig Institute for Cancer Research
Grant: 2001AA215411, 30531160045, 30570393, KSP #003, 30531160045
Resource Type(s): Database
Resource: Resource
URL: http://www.bioinfo.org.cn/hptaa/
Id: nif-0000-02987
PMID: PMID 16381942
Keywords: cancer, tumor, tumor-associated antigen
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Notes

This page uses this default form:Resource

Old url: http://www.hptaa.org

Contributors

Aarnaud, Ccdbuser, Nifbot2, Zaidaziz



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Facts about Resource:Human Potential Tumor Associated Antigen databaseRDF feed
CurationStatuscurated  +
DefiningCitationhttp://www.bioinfo.org.cn/hptaa/  +
DefinitionTo accelerate the process of tumor antigen To accelerate the process of tumor antigen discovery, we generated a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with pTAAs identified by insilico computing. 3518 potential targets have been included in the database, which is freely available to academic users. It successfully screened out 41 of 82 known Cancer-Testis antigens, 6 of 18 differentiation antigen, 2 of 2 oncofetal antigen, and 7 of 12 FDA approved cancer markers that have Gene ID, therefore will provide a good platform for identification of cancer target genes.

This database utilizes expression data from various expression platforms, including carefully chosen publicly available microarray expression data, GEO SAGE data, Unigene expression data. In addition, other relevant databases required for TAA discovery such as CGAP, CCDS, gene ontology database etc, were also incorporated.

In order to integrate different expression platforms together, various strategies and algorithms have been developed. Known tumor antigens are gathered from literature and serve as training sets. A total tumor specificity penalty was computed from positive clue penalty for differential expression in human cancers, the corresponding differential ratio, and normal tissue restriction penalty for each gene.

We hope this database will help with the process of cancer immunome identification, thus help with improving the diagnosis and treatment of human carcinomas.
and treatment of human carcinomas.


GrantCategory:2001AA215411   +, Category:30531160045   +, Category:30570393   +, and Category:KSP #003   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleDatabase  +
Idnif-0000-02987  +
Is part ofChinese Academy of Sciences; Beijing; China  +
KeywordsCancer  +, Tumor  +, and Tumor-associated antigen  +
LabelResource:Human Potential Tumor Associated Antigen database  +
ModifiedDate6 June 2011  +
PMID16381942  +
Page has default formThis property is a special property in this wiki.Resource  +
SuperCategoryResource  +
Supporting AgencyNational 863 program in China  +, National Natural Science Foundation of China  +, and Ludwig Institute for Cancer Research  +
SynonymHPtaa Database  +