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Resource:IUPHAR Database

Name: Resource:IUPHAR Database
Description:

The IUPHAR database is an established online reference resource for several important classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database incorporates detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels and Nuclear Hormone Receptors (NHRs).

Data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures.

Recent developments include curation of the chemical structures of approximately 2000 ligand molecules, providing electronic descriptors, identifiers, link-outs and calculated molecular properties, all available via enhanced ligand pages.

The interface provides intelligent tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target.

IUPHAR-DB contributors
The IUPHAR database is developed under the auspices of NC-IUPHAR to provide an accurate educative resource to the scientific community. It relies on contributions by expert pharmacologists who volunteer their time. All contributors are attributed on the website, allowing receptor data pages to be properly cited.

Annotation procedure
NC-IUPHAR has a network of expert subcommittees (presently over 60), each responsible for developing the nomenclature for a receptor family and contributing data. Where no relevant subcommittee exists, data are captured by the curators or individual experts and peer reviewed by at least two external expert referees.

The data

The data are summarized from selected primary literature articles, which are linked to PubMed. Where possible the data are linked to other relevant databases for further information.
Other Name(s): International Union of Pharmacology Database, International Union of Basic and Clinical Pharmacology Database
Abbreviation: IUPHAR-DB, IUPHAR GPCR, IUPHAR RECEPTOR
Parent Organization: Resource:NC-IUPHAR
Supporting Agency: British Pharmacological Society, Abbott, GlaxoSmithKline, Incyte, Millipore, Novartis, Servier, UNESCO, Wyeth
Resource Type(s): Database, International standard specification
Resource: Resource
URL: http://www.iuphar-db.org
*Id: nif-0000-03056
PMID: PMID 21087994
Keywords: human, rodent, Gold standard or authority
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Notes

This page uses this default form:Resource

Contributors

Aarnaud, Ccdbuser, Cwang



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Facts about Resource:IUPHAR DatabaseRDF feed
AbbrevIUPHAR-DB, IUPHAR GPCR, IUPHAR RECEPTOR  +
CurationStatusuncurated  +
DefiningCitationhttp://www.iuphar-db.org  +
Definition

The IUPHAR database is an establis
The IUPHAR database is an established online reference resource for several important classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database incorporates detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels and Nuclear Hormone Receptors (NHRs).

Data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures.

Recent developments include curation of the chemical structures of approximately 2000 ligand molecules, providing electronic descriptors, identifiers, link-outs and calculated molecular properties, all available via enhanced ligand pages.

The interface provides intelligent tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target.

IUPHAR-DB contributors
The IUPHAR database is developed under the auspices of NC-IUPHAR to provide an accurate educative resource to the scientific community. It relies on contributions by expert pharmacologists who volunteer their time. All contributors are attributed on the website, allowing receptor data pages to be properly cited.

Annotation procedure
NC-IUPHAR has a network of expert subcommittees (presently over 60), each responsible for developing the nomenclature for a receptor family and contributing data. Where no relevant subcommittee exists, data are captured by the curators or individual experts and peer reviewed by at least two external expert referees.

The data

The data are summarized from selected primary literature articles, which are linked to PubMed. Where possible the data are linked to other relevant databases for further information. elevant databases for further information.
Has default formThis property is a special property in this wiki.Resource  +
Has roleDatabase  +, and International standard specification  +
Idnif-0000-03056  +
Is part ofResource:NC-IUPHAR  +
KeywordsHuman  +, Rodent  +, and Gold standard  +
LabelResource:IUPHAR Database  +
ModifiedDate30 July 2014  +
PMID21087994  +
Page has default formThis property is a special property in this wiki.Resource  +
SuperCategoryResource  +
Supporting AgencyBritish Pharmacological Society  +, Abbott Laboratories  +, GlaxoSmithKline  +, Incyte  +, Millipore  +, Novartis  +, Servier  +, UNESCO  +, and Wyeth  +
SynonymInternational Union of Pharmacology Database  +, and International Union of Basic and Clinical Pharmacology Database  +