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Resource:Induced Mutant Resource

Name: Resource:Induced Mutant Resource
Description: THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2012.

The function of the IMR is to select, import, cryopreserve, maintain, and distribute these important strains of mice to the research community. To improve their value for research, the IMR also undertakes genetic development of stocks, such as transferring mutant genes or transgenes to defined genetic backgrounds and combining transgenes and/or targeted mutations to create new mouse models for research.
The function of the IMR is to:

  • select biomedically important stocks of transgenic, chemically induced, and targeted mutant mice
  • import these stocks into the Jackson Laboratory by rederivation procedures that rid them of any pathogens they might carry
  • cryopreserve embryos from these stocks to protect them against accidental loss and genetic contamination
  • backcross the mutation onto an inbred strain, if necessary
  • distribute them to the scientific community

More than 1000 mutant stocks have been accepted by the IMR from 1992 through December 2006. Current holdings include models for research on cancer; breast cancer; immunological and inflammatory diseases; neurological diseases; behavioral, cardiovascular and heart diseases; developmental, metabolic and other diseases; reporter (e.g., GFP) and recombinase (e.g., cre/loxP) strains. About eight strains a month are being added to the IMR holdings.

Research is being conducted on improved methods for assisted reproduction and speed congenic production. Most of the targeted mutants arrive on a mixed 129xC57BL/6 genetic background, and as many of these as possible are backcrossed onto an inbred strain (usually C57BL/6J). In addition, new mouse models are being created by intercrossing carriers of specific transgenes and/or targeted mutations. Simple sequence length polymorphism DNA markers are being used to characterize and evaluate differences between inbred strains, substrains, and embryonic stem cell lines.
Parent Organization: Resource:Jackson Laboratory
Supporting Agency: March of Dimes Birth Defects Foundation, American Cancer Society, American Heart Association, Cystic Fibrosis Foundation, Resource:National Multiple Sclerosis Society, Amyotrophic Lateral Sclerosis Association, NCRR, NIAID, NIAMS, Howard Hughes Medical Institute, Department of the Army Breast Cancer Research Initiative.
Resource Type(s): Material storage repository, Biomaterial manufacture, Organism supplier
Keywords: embryo, genetic, behavioral, biomedical, breast cancer, cancer, cardiovascular, chemical, cre, cryopreserved, developmental, disease, distribution, dna, gfp, heart, immunological, inflammatory, loxp, marker, metabolic, model, mouse, mutation, neurological, pathogen, polymorphism, recombinase, research, stock, targeting, transgene
Grant: P40 RR009781
Abbreviation: IMR
Resource: Resource
URL: http://www.jax.org/imr/index.html
Availability: THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2012.
Id: nif-0000-25566
Organism: Mouse
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Notes

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Contributors

Aarnaud, Akash, Bandrow, Ccdbuser, Nifbot2



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Facts about Resource:Induced Mutant ResourceRDF feed
AbbrevIMR  +
AvailabilityTHIS RESOURCE IS NO LONGER IN SERVICE  +, Documented on June 08  +, and 2012.  +
CurationStatusuncurated  +
DefiningCitationhttp://www.jax.org/imr/index.html  +
DefinitionTHIS RESOURCE IS NO LONGER IN SERVICE, doc THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2012.

The function of the IMR is to select, import, cryopreserve, maintain, and distribute these important strains of mice to the research community. To improve their value for research, the IMR also undertakes genetic development of stocks, such as transferring mutant genes or transgenes to defined genetic backgrounds and combining transgenes and/or targeted mutations to create new mouse models for research.
The function of the IMR is to:

  • select biomedically important stocks of transgenic, chemically induced, and targeted mutant mice
  • import these stocks into the Jackson Laboratory by rederivation procedures that rid them of any pathogens they might carry
  • cryopreserve embryos from these stocks to protect them against accidental loss and genetic contamination
  • backcross the mutation onto an inbred strain, if necessary
  • distribute them to the scientific community

More than 1000 mutant stocks have been accepted by the IMR from 1992 through December 2006. Current holdings include models for research on cancer; breast cancer; immunological and inflammatory diseases; neurological diseases; behavioral, cardiovascular and heart diseases; developmental, metabolic and other diseases; reporter (e.g., GFP) and recombinase (e.g., cre/loxP) strains. About eight strains a month are being added to the IMR holdings.

Research is being conducted on improved methods for assisted reproduction and speed congenic production. Most of the targeted mutants arrive on a mixed 129xC57BL/6 genetic background, and as many of these as possible are backcrossed onto an inbred strain (usually C57BL/6J). In addition, new mouse models are being created by intercrossing carriers of specific transgenes and/or targeted mutations. Simple sequence length polymorphism DNA markers are being used to characterize and evaluate differences between inbred strains, substrains, and embryonic stem cell lines.
ains, and embryonic stem cell lines.
GrantCategory:P40 RR009781   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleMaterial storage repository  +, Biomaterial manufacture  +, and Organism supplier  +
Idnif-0000-25566  +
Is part ofResource:Jackson Laboratory  +
KeywordsEmbryo  +, Genetic  +, Behavioral  +, Biomedical  +, Breast cancer  +, Cancer  +, Cardiovascular  +, Chemical  +, Cre  +, Cryopreserved  +, Developmental  +, Disease  +, Distribution  +, Dna  +, Gfp  +, Heart  +, Immunological  +, Inflammatory  +, Loxp  +, Marker  +, Metabolic  +, Model  +, Mouse  +, Mutation  +, Neurological  +, Pathogen  +, Polymorphism  +, Recombinase  +, Research  +, Stock  +, Targeting  +, and Transgene  +
LabelResource:Induced Mutant Resource  +
ModifiedDate12 April 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
SpeciesMouse  +
SuperCategoryResource  +
Supporting AgencyMarch of Dimes Birth Defects Foundation  +, American Cancer Society  +, American Heart Association  +, Cystic Fibrosis Foundation  +, Resource:National Multiple Sclerosis Society  +, Amyotrophic Lateral Sclerosis Association  +, National Center for Research Resources  +, National Institute of Allergy and Infectious Diseases  +, National Institute of Arthritis and Musculoskeletal and Skin Diseases  +, Howard Hughes Medical Institute  +, and Department of the Army Breast Cancer Research Initiative.  +