arrow

From NeuroLex

Jump to: navigation, search



Resource:Institute of Experimental Medicine of the Hungarian Academy of Sciences: Laboratory of Cerebral Cortext Reserach

Name: Resource:Institute of Experimental Medicine of the Hungarian Academy of Sciences: Laboratory of Cerebral Cortext Reserach
Description: The aim of this laboratory is to understand how information is encoded in specific spatiotemporal activity patterns and structural configurations at the circuit, cellular, and molecular levels in the hippocampus, thereby enabling the process of memory.

A major task is to find the neuronal codes of internal representations of memory items and the mapping rules between the levels of gene expression/proteins synthesis and the level of cognitive processing. Novel combinations of approaches, including multiple single-cell recording technology, patch-clamp electrophysiology, neuroanatomy/neurochemistry at the cellular and subcellular levels, and computational models are employed to test specific hypotheses about that mapping process (such as local circuit anatomy and activity-dependent short-term and long-term synaptic plasticity). Collaborations within the Institute allows the group to also incorporate gene targeting methods and behavioral learning/memory tests in their methodological repertoire.

The laboratory has been focusing on the normal and pathological (epileptic, ischemic) activity of cortical networks, with particular attention to the generation of behaviour-dependent population discharge patterns (theta and gamma oscillations, hippocampal sharp waves). Anatomical, in vitro and in vivo electrophysiological, pharmacological and molecular techniques and modeling are combined to elucidate the functional roles of inhibitory cell types in the control of population synchrony and synaptic plasticity in the hippocampus, their local and subcortical modulation via selective afferent pathways (GABAergic and cholinergic septal, as well as serotonergic raphe input) and pre- or postsynaptic receptors. An expanding new direction of research is related to the role of endocannabinoid signaling in the activity-dependent modulation of GABAergic and glutamatergic transmission, and its involvement in anxiety-like behavior.
Other Name(s): KOKI
Parent Organization: Institute of Experimental Medicine of the Hungarian Academy of Sciences
Resource Type(s): Laboratory portal
Resource: Resource
URL: http://www.koki.hu/main.php?folderID=903
*Id: nif-0000-10257
Keywords: electrophysiology, experimental, expression, gaba, gene, anatomy, anxiety, behavior, cell, cellular, circuit, cognitive, computational, cortical, hippocampus, laboratory, mapping, medicine, memory, molecular, neuroanatomy, neurochemistry, plasticity, processing, protein, serotonin, spatiotemporal, structural, subcellular, subcortical, synaptic
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

This resource will be curated within 7 days.

For Resource Owners:
After the resource is curated, you may create a sitemap, which will help keep your registry description up-to-date and inform search engines about your resource.

Note: For a new resource, the website's URL must first be verified by a NIF curator before you may proceed.

Learn more about what NIF can do for your resource.
Proudly proclaim your inclusion in NIF by displaying the "Registered with NIF" button on your site. Please login to create the sitemap. (top right)

This page uses this default form:Resource

Contributors

Aarnaud, Ccdbuser, Memartone, Nifbot2



bookmark

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:Institute of Experimental Medicine of the Hungarian Academy of Sciences: Laboratory of Cerebral Cortext ReserachRDF feed
CurationStatusuncurated  +
DefiningCitationhttp://www.koki.hu/main.php?folderID=903  +
DefinitionThe aim of this laboratory is to understan The aim of this laboratory is to understand how information is encoded in specific spatiotemporal activity patterns and structural configurations at the circuit, cellular, and molecular levels in the hippocampus, thereby enabling the process of memory.

A major task is to find the neuronal codes of internal representations of memory items and the mapping rules between the levels of gene expression/proteins synthesis and the level of cognitive processing. Novel combinations of approaches, including multiple single-cell recording technology, patch-clamp electrophysiology, neuroanatomy/neurochemistry at the cellular and subcellular levels, and computational models are employed to test specific hypotheses about that mapping process (such as local circuit anatomy and activity-dependent short-term and long-term synaptic plasticity). Collaborations within the Institute allows the group to also incorporate gene targeting methods and behavioral learning/memory tests in their methodological repertoire.

The laboratory has been focusing on the normal and pathological (epileptic, ischemic) activity of cortical networks, with particular attention to the generation of behaviour-dependent population discharge patterns (theta and gamma oscillations, hippocampal sharp waves). Anatomical, in vitro and in vivo electrophysiological, pharmacological and molecular techniques and modeling are combined to elucidate the functional roles of inhibitory cell types in the control of population synchrony and synaptic plasticity in the hippocampus, their local and subcortical modulation via selective afferent pathways (GABAergic and cholinergic septal, as well as serotonergic raphe input) and pre- or postsynaptic receptors. An expanding new direction of research is related to the role of endocannabinoid signaling in the activity-dependent modulation of GABAergic and glutamatergic transmission, and its involvement in anxiety-like behavior.
nvolvement in anxiety-like behavior.
Has default formThis property is a special property in this wiki.Resource  +
Has roleLaboratory portal  +
Idnif-0000-10257  +
Is part ofInstitute of Experimental Medicine of the Hungarian Academy of Sciences  +
KeywordsElectrophysiology  +, Experimental  +, Expression  +, Gaba  +, Gene  +, Anatomy  +, Anxiety  +, Behavior  +, Cell  +, Cellular  +, Circuit  +, Cognitive  +, Computational  +, Cortical  +, Hippocampus  +, Laboratory  +, Mapping  +, Medicine  +, Memory  +, Molecular  +, Neuroanatomy  +, Neurochemistry  +, Plasticity  +, Processing  +, Protein  +, Serotonin  +, Spatiotemporal  +, Structural  +, Subcellular  +, Subcortical  +, and Synaptic  +
LabelResource:Institute of Experimental Medicine of the Hungarian Academy of Sciences: Laboratory of Cerebral Cortext Reserach  +
ModifiedDate21 June 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
SuperCategoryResource  +
SynonymKOKI  +