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Resource:JAX Neuroscience Mutagenesis Facility

Name: Resource:JAX Neuroscience Mutagenesis Facility
Description: Produce new neurological mouse models that could serve as experimental models for the exploration of basic neurobiological mechanisms and diseases.

The impetus for the program resulted from the recognition that:

  • The value of genomic data would remain limited unless more information about the functionality of its individual components became available.
  • The task of linking genes to specific behavior would best be accomplished by employing a combination of different approaches. In an effort to complement already existing programs, the Neuroscience Mutagenesis Facility decided to use: a random, genome-wide approach to mutagenesis, i.e.N-ethyl-N-nitrosourea (ENU) as the mutagen; a three-generation back-cross breeding scheme to focus on the detection of recessive mutations; behavioral screens selective for the detection of phenotypes deemed useful for the program goals.

The resulting mutant mouse lines have been available to the scientific community for the last five years and over 700 NMF mice have been sent to interested investigators for research; these mutant mouse lines will remain available as frozen embryos (which can be re-derived on request) and can be ordered through the JAX customer service at 1-800-422-6423 (or 207-288-5845).

The results of the work of the Neuroscience Mutagenesis Facility and that of two other neurogenesis centers, i.e. The Neurogenomics Project at Northwestern University, and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium, can also be seen at Neuromice.org, a common web site of these three research centers; in addition, information about all mutants produced by these groups has been recorded in MGI.
Other Name(s): Neuroscience Mutagenesis Facility of the Jackson Laboratory, Neuromutagenesis Facility, JAX Neuromutagenesis Facility, JAX - Neuroscience Mutagenesis Facilty
Abbreviation: NMU
Parent Organization: Resource:Jackson Laboratory
Supporting Agency: NIDA, NIMH, NINDS, NEI, NIA, NIAAA, NIDCD
Resource Type(s): Organism supplier
Resource: Resource
URL: http://jaxmice.jax.org/list/ra1642.html
*Id: nif-0000-00784
Related condition/disease: neurobiological disease, neurological disorder, sensory disorder, behavioral disorder
Related application: Research
Processing: Frozen
Related to: Resource:neuromice, Resource:MGI, Resource:One Mind Biospecimen Bank Listing, US Biobank
Availability: Public, available to the scientific community
Keywords: mouse model, mutant mouse line, mutant mouse, phenodeviant, phenodeviant mouse, heritability, phenotyping, genetic mapping
Organism: Mouse
Link to OWL / RDF: Download this content as OWL/RDF

Parts of Resource:JAX Neuroscience Mutagenesis Facility

Curation status: Uncurated

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Notes

This page uses this default form:Resource

Old URL: http://nmf.jax.org/

Contributors

Aarnaud, Akash, Ccdbuser, Jugama, Zaidaziz



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:JAX Neuroscience Mutagenesis FacilityRDF feed
AbbrevNMU  +
AvailabilityPublic  +, and Available to the scientific community  +
CommentSample type: Embryo
CurationStatuscurated  +
DefiningCitationhttp://jaxmice.jax.org/list/ra1642.html  +
DefinitionProduce new neurological mouse models that Produce new neurological mouse models that could serve as experimental models for the exploration of basic neurobiological mechanisms and diseases.

The impetus for the program resulted from the recognition that:

  • The value of genomic data would remain limited unless more information about the functionality of its individual components became available.
  • The task of linking genes to specific behavior would best be accomplished by employing a combination of different approaches. In an effort to complement already existing programs, the Neuroscience Mutagenesis Facility decided to use: a random, genome-wide approach to mutagenesis, i.e.N-ethyl-N-nitrosourea (ENU) as the mutagen; a three-generation back-cross breeding scheme to focus on the detection of recessive mutations; behavioral screens selective for the detection of phenotypes deemed useful for the program goals.

The resulting mutant mouse lines have been available to the scientific community for the last five years and over 700 NMF mice have been sent to interested investigators for research; these mutant mouse lines will remain available as frozen embryos (which can be re-derived on request) and can be ordered through the JAX customer service at 1-800-422-6423 (or 207-288-5845).

The results of the work of the Neuroscience Mutagenesis Facility and that of two other neurogenesis centers, i.e. The Neurogenomics Project at Northwestern University, and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium, can also be seen at Neuromice.org, a common web site of these three research centers; in addition, information about all mutants produced by these groups has been recorded in MGI.
by these groups has been recorded in MGI.
ExampleImageNMF.PNG  +
Has default formThis property is a special property in this wiki.Resource  +
Has roleOrganism supplier  +
Idnif-0000-00784  +
Is part ofResource:Jackson Laboratory  +
KeywordsMouse model  +, Mutant mouse line  +, Mutant mouse  +, Phenodeviant  +, Phenodeviant mouse  +, Heritability  +, Phenotyping  +, and Genetic mapping  +
LabelResource:JAX Neuroscience Mutagenesis Facility  +
ModifiedDate3 July 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
ProcessingFrozen  +
RelatedToResource:neuromice  +, Resource:MGI  +, Resource:One Mind Biospecimen Bank Listing  +, and US Biobank  +
Related applicationResearch  +
Related diseaseNeurobiological disease  +, Neurological disorder  +, Sensory disorder  +, and Behavioral disorder  +
SpeciesMouse  +
SuperCategoryResource  +
Supporting AgencyNIDA  +, NIMH  +, NINDS  +, NEI  +, NIA  +, NIAAA  +, and NIDCD  +
SynonymNeuroscience Mutagenesis Facility of the Jackson Laboratory  +, Neuromutagenesis Facility  +, JAX Neuromutagenesis Facility  +, and JAX - Neuroscience Mutagenesis Facilty  +