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Resource:Malaria Parasite Metabolic Pathways

Name: Resource:Malaria Parasite Metabolic Pathways
Description: Data set of metabolic pathways for the malaria parasite based on the present knowledge of parasite biochemistry and on pathways known to occur in other unicellular eukaryotes. This site extracted the pertinent information from the universal sites and presented them in an educative and informative format. The site also includes, cell-cell interactions (cytoadherence and rosetting), invasion of the erythrocyte by the parasite and transport functions. It also contains an artistic impression of the ultrastructural morphology of the interaerythrocytic cycle stages and some details about the morphology of mitochondria and the apicoplast.

Most pathways are relevant to the erythrocytic phase of the parasite cycle. All maps were checked for the presence of enzyme-coding genes as they are officially annotated in the Plasmodium genome (http://plasmodb.org/).

The site is constructed in a hierarchical pattern that permits logical deepening:

  • Grouped pathways of major chemical components or biological process
    • Specific pathways or specific process
      • Chemical structures of substrates and products or process
        • Names of enzymes and their genes or components of process
Each map is linked to other maps thus enabling to verify the origin of a substrate or the fate of a product. Clicking on the EC number that appears next to each enzyme, connects the site to BRENDA, SWISSPROT ExPASy ENZYME, PlasmoDB and to IUBMB reaction scheme. Clicking of the name of a metabolite, connects the site to KEGG thus providing its chemical structure and formula. Next to each enzyme there is a pie that depicts the stage-dependent transcription of the enzyme's coding gene. The pie is constructed as a clock of the 48 hours of the parasite cycle, where red signifies over-transcription and green, under-transcription. Clicking on the pie links to the DeRisi/UCSF transcriptome database.
Abbreviation: Malaria Parasite Metabolic Pathways
Parent Organization: Hebrew University of Jerusalem; Jerusalem; Israel
Supporting Agency: UNDP/World Bank/WHO Special Programme, NIAID, EU, (6th Framework Programme - BioMalPar Network of Excellence on Biology and Pathology of the Malaria Parasite)
Grant: LSHP-CT-2004-503578
Resource Type(s): Data set, Image collection
Resource: Resource
URL: http://sites.huji.ac.il/malaria/
*Id: nif-0000-21249
Related condition/disease: Malaria
Keywords: enzyme, gene, genome, map, metabolic, mosquito, parasite, pathway, plasmodium falciparum, protein, reaction, sequence, metabolic pathway, Chemical structure, cell-cell interaction, transport, morphology, mitochondria, apicoplast
Organism: Plasmodium
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Curated

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Facts about Resource:Malaria Parasite Metabolic PathwaysRDF feed
AbbrevMalaria Parasite Metabolic Pathways  +
CurationStatuscurated  +
DefiningCitationhttp://sites.huji.ac.il/malaria/  +
DefinitionData set of metabolic pathways for the mal Data set of metabolic pathways for the malaria parasite based on the present knowledge of parasite biochemistry and on pathways known to occur in other unicellular eukaryotes. This site extracted the pertinent information from the universal sites and presented them in an educative and informative format. The site also includes, cell-cell interactions (cytoadherence and rosetting), invasion of the erythrocyte by the parasite and transport functions. It also contains an artistic impression of the ultrastructural morphology of the interaerythrocytic cycle stages and some details about the morphology of mitochondria and the apicoplast.

Most pathways are relevant to the erythrocytic phase of the parasite cycle. All maps were checked for the presence of enzyme-coding genes as they are officially annotated in the Plasmodium genome (http://plasmodb.org/).

The site is constructed in a hierarchical pattern that permits logical deepening:

  • Grouped pathways of major chemical components or biological process
    • Specific pathways or specific process
      • Chemical structures of substrates and products or process
        • Names of enzymes and their genes or components of process
Each map is linked to other maps thus enabling to verify the origin of a substrate or the fate of a product. Clicking on the EC number that appears next to each enzyme, connects the site to BRENDA, SWISSPROT ExPASy ENZYME, PlasmoDB and to IUBMB reaction scheme. Clicking of the name of a metabolite, connects the site to KEGG thus providing its chemical structure and formula. Next to each enzyme there is a pie that depicts the stage-dependent transcription of the enzyme's coding gene. The pie is constructed as a clock of the 48 hours of the parasite cycle, where red signifies over-transcription and green, under-transcription. Clicking on the pie links to the DeRisi/UCSF transcriptome database.
to the DeRisi/UCSF transcriptome database.
GrantCategory:LSHP-CT-2004-503578   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleData set  +, and Image collection  +
Idnif-0000-21249  +
Is part ofHebrew University of Jerusalem; Jerusalem; Israel  +
KeywordsEnzyme  +, Gene  +, Genome  +, Map  +, Metabolic  +, Mosquito  +, Parasite  +, Pathway  +, Plasmodium falciparum  +, Protein  +, Reaction  +, Sequence  +, Metabolic pathway  +, Chemical structure  +, Cell-cell interaction  +, Transport  +, Morphology  +, Mitochondria  +, and Apicoplast  +
LabelResource:Malaria Parasite Metabolic Pathways  +
ModifiedDate13 March 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
Related diseaseMalaria  +
SpeciesPlasmodium  +
SuperCategoryResource  +
Supporting AgencyUNDP/World Bank/WHO Special Programme  +, National Institute of Allergy and Infectious Diseases  +, European Union  +, and (6th Framework Programme - BioMalPar Network of Excellence on Biology and Pathology of the Malaria Parasite)  +