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Resource:Mouse Mutagenesis Center for Developmental Defects

Name: Resource:Mouse Mutagenesis Center for Developmental Defects
Description: THIS RESOURCE IS NO LONGER IN SERVICE. For updated mutant information, please visit MMRRC or The Jackson Laboratory.

Produces, characterizes, and distributes mutant mouse strains with defects in embryonic and postembryonic development.

The goal of the ENU Mutagenesis project III is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval.
Other Name(s): NIH Mouse Mutagenesis Center for Developmental Defects
Abbreviation: Mouse Mutagenesis for Developmental Defects
Parent Organization: Baylor College of Medicine; Texas; USA
Supporting Agency: NICHD, NIGMS, NIA, NIAMS, NHLBI, NIDDK, NIDCR, Resource:NIH Blueprint for Neuroscience Research
Resource Type(s): Organism supplier, Biomaterial manufacture
Resource: Resource
URL: http://www.mouse-genome.bcm.tmc.edu/ENU/MutagenesisProj.asp
*Id: nif-0000-00190
Related to: Resource:One Mind Biospecimen Bank Listing, US Biobank, Resource:Mutant Mouse Regional Resource Centers, Resource:Jackson Laboratory, Resource:DKnet
Address: Baylor College of Medicine, The Mouse Genome Project, One Baylor Plaza, Houston TX 77030 Phone: 713-798-1197
Keywords: Mutant, Embryo, Post embryonic, Mutagenesis, Craniofacial, Eye, Fertility, Growth, Lethal, Metabolism, Neurological, Skeletal, Skin, Coat, Urogenital, Cryopreserved, ENU, Defect, birth defect, patterning defect, growth defect, endocrine defects, neurological anomaly, blood defect, Mouse model, Human disease, N-ethyl-N-nitrosourea, chromosome 11, phenotype
Organism: Mouse
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Facts about Resource:Mouse Mutagenesis Center for Developmental DefectsRDF feed
AbbrevMouse Mutagenesis for Developmental Defects  +
AddressBaylor College of Medicine  +, The Mouse Genome Project  +, One Baylor Plaza  +, and Houston TX 77030 Phone: 713-798-1197  +
CurationStatusuncurated  +
DefiningCitationhttp://www.mouse-genome.bcm.tmc.edu/ENU/MutagenesisProj.asp  +
DefinitionTHIS RESOURCE IS NO LONGER IN SERVICE. For THIS RESOURCE IS NO LONGER IN SERVICE. For updated mutant information, please visit MMRRC or The Jackson Laboratory.

Produces, characterizes, and distributes mutant mouse strains with defects in embryonic and postembryonic development.

The goal of the ENU Mutagenesis project III is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval.
bination over a reasonable interval.
ExampleImageMouse Mutagenesis Center for Developmental Defects.PNG  +
Has default formThis property is a special property in this wiki.Resource  +
Has roleOrganism supplier  +, and Biomaterial manufacture  +
Idnif-0000-00190  +
Is part ofBaylor College of Medicine; Texas; USA  +
KeywordsMutant  +, Embryo  +, Post embryonic  +, Mutagenesis  +, Craniofacial  +, Eye  +, Fertility  +, Growth  +, Lethal  +, Metabolism  +, Neurological  +, Skeletal  +, Skin  +, Coat  +, Urogenital  +, Cryopreserved  +, ENU  +, Defect  +, Birth defect  +, Patterning defect  +, Growth defect  +, Endocrine defects  +, Neurological anomaly  +, Blood defect  +, Mouse model  +, Human disease  +, N-ethyl-N-nitrosourea  +, Chromosome 11  +, and Phenotype  +
LabelResource:Mouse Mutagenesis Center for Developmental Defects  +
ModifiedDate4 November 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
RelatedToResource:One Mind Biospecimen Bank Listing  +, US Biobank  +, Resource:Mutant Mouse Regional Resource Centers  +, Resource:Jackson Laboratory  +, and Resource:DKnet  +
SpeciesMouse  +
SuperCategoryResource  +
Supporting AgencyNICHD  +, NIGMS  +, NIA  +, NIAMS  +, NHLBI  +, NIDDK  +, NIDCR  +, and Resource:NIH Blueprint for Neuroscience Research  +
SynonymNIH Mouse Mutagenesis Center for Developmental Defects  +