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Resource:Mouse Mutagenesis Center for Developmental Defects
| Name: | Resource:Mouse Mutagenesis Center for Developmental Defects |
| Description: | THIS SITE IS RETIRED. For updated mutant information, please visit MMRRC or The Jackson Laboratory.
Produces, characterizes, and distributes mutant mouse strains with defects in embryonic and postembryonic development. The goal of the ENU Mutagenesis project III is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval. |
| Other Name(s): | NIH Mouse Mutagenesis Center for Developmental Defects |
| Parent Organization: | Baylor College of Medicine; Texas; USA |
| Supporting Agency: | NICHD, NIGMS, NIA, NIAMS, NHLBI, NIDDK, NIDCR, Resource:NIH Blueprint for Neuroscience Research |
| Related to: | Resource:One Mind Biospecimen Bank Listing, US Biobank |
| Resource Type(s): | Organism supplier, Biomaterial manufacture |
| Keywords: | Mutant, Embryo, Post embryonic, Mutagenesis, Craniofacial, Eye, Fertility, Growth, Lethal, Metabolism, Neurological, Skeletal, Skin, Coat, Urogenital, Cryopreserved, ENU, Defect, birth defect, patterning defect, growth defect, endocrine defects, neurological anomaly, blood defect, Mouse model, Human disease, N-ethyl-N-nitrosourea, chromosome 11, phenotype |
| Abbreviation: | Mouse Mutagenesis for Developmental Defects |
| Resource: | Resource |
| URL: | http://www.mouse-genome.bcm.tmc.edu/ENU/MutagenesisProj.asp |
| Address: | Baylor College of Medicine, The Mouse Genome Project, One Baylor Plaza, Houston TX 77030 Phone: 713-798-1197 |
| Id: | nif-0000-00190 |
| Organism: | Mouse |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Curation status: Curated
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| Abbrev | Mouse Mutagenesis for Developmental Defects + |
| Address | Baylor College of Medicine +, The Mouse Genome Project +, One Baylor Plaza +, and Houston TX 77030 Phone: 713-798-1197 + |
| CurationStatus | curated + |
| DefiningCitation | http://www.mouse-genome.bcm.tmc.edu/ENU/MutagenesisProj.asp + |
| Definition | THIS SITE IS RETIRED. For updated mutant i … THIS SITE IS RETIRED. For updated mutant information, please visit MMRRC or The Jackson Laboratory.
Produces, characterizes, and distributes mutant mouse strains with defects in embryonic and postembryonic development. The goal of the ENU Mutagenesis project III is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval.bination over a reasonable interval. |
| ExampleImage |  + |
| Has default formThis property is a special property in this wiki. | Resource + |
| Has role | Organism supplier +, and Biomaterial manufacture + |
| Id | nif-0000-00190 + |
| Is part of | Baylor College of Medicine; Texas; USA + |
| Keywords | Mutant +, Embryo +, Post embryonic +, Mutagenesis +, Craniofacial +, Eye +, Fertility +, Growth +, Lethal +, Metabolism +, Neurological +, Skeletal +, Skin +, Coat +, Urogenital +, Cryopreserved +, ENU +, Defect +, Birth defect +, Patterning defect +, Growth defect +, Endocrine defects +, Neurological anomaly +, Blood defect +, Mouse model +, Human disease +, N-ethyl-N-nitrosourea +, Chromosome 11 +, and Phenotype + |
| Label | Resource:Mouse Mutagenesis Center for Developmental Defects + |
| ModifiedDate | 3 December 2012 + |
| Page has default formThis property is a special property in this wiki. | Resource + |
| RelatedTo | Resource:One Mind Biospecimen Bank Listing +, and US Biobank + |
| Species | Mouse + |
| SuperCategory | Resource + |
| Supporting Agency | NICHD +, NIGMS +, NIA +, NIAMS +, NHLBI +, NIDDK +, NIDCR +, and Resource:NIH Blueprint for Neuroscience Research + |
| Synonym | NIH Mouse Mutagenesis Center for Developmental Defects + |
