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Resource:NeuroMouse Database

Name: Resource:NeuroMouse Database
Description: Toolbook(tm) based, interactive graphical database which provides structural, molecular, and genetic information on the adult murine nervous system; and its relevance to human neurobiology. This resource is primarily designed as a platform for users to interact, each sharing knowledge on their own area of expertise, which is compiled to a master database.

This hypertext atlas presently comprises more than 1000 pages and is designed to provide a flexible integrated resource for the description and discussion of all forms mammalian neurologic data. Version 4.0 of the NeuroMouse program extends the program's basic framework to include a number of areas in modern molecular neurobiology.

This system provides an integrated resource for the characterization and description of mammalian neurological data. Major divisions include: Neural Atlas, Molecular Atlas, Genetics/Surgical Lesion Atlas. Neuromouse has been integrated into our strain-specific three dimensional MRI and surgical atlases of the murine CNS.

Database contents:
Neural Atlas:
- Rotational representation of the murine brain.
- Neural structures: visual and alphabetic point and click index of neural structures, pathways and systems.
- Brain atlas:photographic serial sections in the coronal, sagittal, and horizontal planes (average plate distance - 300 um). Physical brain distances are also provided as are meta-index grids to allow rapid movement between different planes and regions.

  1. Catalog of primary and immortalized neural cells indexed to relevant neural structures.

Molecular Atlas:
- Index of neurotransmitters: Acetylcholine, GABA, Glutamate, Aspartate, Glycine, Dopamine, Norepinephrine, Epinephrine, Serotonin (synthesis, distribution, degradation, molecular modules, receptors, subunits, agonists, antagonists, gene structure, localization, physical properties and transgenics are indicated for each item).
- Index of neurotrophins / neurokines: NGF, BDNF, NT-3, NT-4/5, CNTF, LIF, Onostain M, IL-6, GDNF, FGF's, S100b (ligand, receptors, expression pattern, physical properties, homologous factors, transgenics/knockouts, chromosomal location, effects of agent, and effects of factors on agent are indicated for each item).
- Index of "additional" neural agents: Bcl-2, TNF/Fas, TGF-beta, P53/Rb, PDGF, EGF family (ligand, receptor, expression patterns, physical properties, homologous factors, transgenics/ knockouts, chromosomal location, effects of agent, effects of factors on agent are indicated for each item).
- Molecular biology: Molecular biology of important neural genes with integrated l links, plus selected neural topics (ex. programmed cell death, inducible gene systems, protein motifs, neural gene elements, and selected signal transduction pathways).
Genetics Atlas:
- Lesion paradigms: Index of common neuronal structural and chemical lesion paradigms.
- Selected procedures: description of common neurosurgical, cell tracing, culturing and laboratory procedures.
- Neurologic syndromes: Index of important human neurologic syndromes and appropriate animals models.

- Neural mutant database: Index and description of naturally occurring and genetically modified murine neurologic mutations; including pages on double "knockout" animals. Interactive maps of each murine chromosome and human syntenic maps.
Resource Type(s): Database, Atlas, Data repository
Keywords: epinephrine, gaba, acetylcholine, agonist, antagonist, aspartate, dopamine, glutamate, glycine, human, molecular biology, murine chromosome, mutant, neural, neural factor, neurokine, neurological, neurotransmitter, n eurotrophin, norepinephrine, serotonin, molecular neuroanatomy resource, nervous system, adult, murine
Abbreviation: NeuroMouse
Resource: Resource
URL: http://phm.utoronto.ca/~jeffh/neuromouse.htm
Id: nif-0000-11000
Organism: Mouse
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Contributors

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Facts about Resource:NeuroMouse DatabaseRDF feed
AbbrevNeuroMouse  +
CurationStatuscurated  +
DefiningCitationhttp://phm.utoronto.ca/~jeffh/neuromouse.htm  +
DefinitionToolbook(tm) based, interactive graphical Toolbook(tm) based, interactive graphical database which provides structural, molecular, and genetic information on the adult murine nervous system; and its relevance to human neurobiology. This resource is primarily designed as a platform for users to interact, each sharing knowledge on their own area of expertise, which is compiled to a master database.

This hypertext atlas presently comprises more than 1000 pages and is designed to provide a flexible integrated resource for the description and discussion of all forms mammalian neurologic data. Version 4.0 of the NeuroMouse program extends the program's basic framework to include a number of areas in modern molecular neurobiology.

This system provides an integrated resource for the characterization and description of mammalian neurological data. Major divisions include: Neural Atlas, Molecular Atlas, Genetics/Surgical Lesion Atlas. Neuromouse has been integrated into our strain-specific three dimensional MRI and surgical atlases of the murine CNS.

Database contents:
Neural Atlas:
- Rotational representation of the murine brain.
- Neural structures: visual and alphabetic point and click index of neural structures, pathways and systems.
- Brain atlas:photographic serial sections in the coronal, sagittal, and horizontal planes (average plate distance - 300 um). Physical brain distances are also provided as are meta-index grids to allow rapid movement between different planes and regions.

  1. Catalog of primary and immortalized neural cells indexed to relevant neural structures.

Molecular Atlas:
- Index of neurotransmitters: Acetylcholine, GABA, Glutamate, Aspartate, Glycine, Dopamine, Norepinephrine, Epinephrine, Serotonin (synthesis, distribution, degradation, molecular modules, receptors, subunits, agonists, antagonists, gene structure, localization, physical properties and transgenics are indicated for each item).
- Index of neurotrophins / neurokines: NGF, BDNF, NT-3, NT-4/5, CNTF, LIF, Onostain M, IL-6, GDNF, FGF's, S100b (ligand, receptors, expression pattern, physical properties, homologous factors, transgenics/knockouts, chromosomal location, effects of agent, and effects of factors on agent are indicated for each item).
- Index of "additional" neural agents: Bcl-2, TNF/Fas, TGF-beta, P53/Rb, PDGF, EGF family (ligand, receptor, expression patterns, physical properties, homologous factors, transgenics/ knockouts, chromosomal location, effects of agent, effects of factors on agent are indicated for each item).
- Molecular biology: Molecular biology of important neural genes with integrated l links, plus selected neural topics (ex. programmed cell death, inducible gene systems, protein motifs, neural gene elements, and selected signal transduction pathways).
Genetics Atlas:
- Lesion paradigms: Index of common neuronal structural and chemical lesion paradigms.
- Selected procedures: description of common neurosurgical, cell tracing, culturing and laboratory procedures.
- Neurologic syndromes: Index of important human neurologic syndromes and appropriate animals models.

- Neural mutant database: Index and description of naturally occurring and genetically modified murine neurologic mutations; including pages on double "knockout" animals. Interactive maps of each murine chromosome and human syntenic maps.
chromosome and human syntenic maps.
Has default formThis property is a special property in this wiki.Resource  +
Has roleDatabase  +, Atlas  +, and Data repository  +
Idnif-0000-11000  +
KeywordsEpinephrine  +, Gaba  +, Acetylcholine  +, Agonist  +, Antagonist  +, Aspartate  +, Dopamine  +, Glutamate  +, Glycine  +, Human  +, Molecular biology  +, Murine chromosome  +, Mutant  +, Neural  +, Neural factor  +, Neurokine  +, Neurological  +, Neurotransmitter  +, N eurotrophin  +, Norepinephrine  +, Serotonin  +, Molecular neuroanatomy resource  +, Nervous system  +, Adult  +, and Murine  +
LabelResource:NeuroMouse Database  +
ModifiedDate1 August 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
SpeciesMouse  +
SuperCategoryResource  +