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Resource:Northwestern CNADC Tissue Bank / Neuropathology Core

Name: Resource:Northwestern CNADC Tissue Bank / Neuropathology Core
Description: Collect, catalog, and store, postmortem brain tissue and other samples from demented subjects and non-demented control individuals; to distribute postmortem brain tissue and other samples to investigators for use in research; and to provide qualitative and quantitative diagnostic information to physicians, families, and researchers.

The CNADC Tissue Bank has many types of specimens available for investigators. In most cases, available tissue includes:

  • Brain Tissue
    • paraformaldehyde-fixed wet tissue
    • paraffin blocks of paraformaldehyde-fixed brain
    • frozen unfixed brain samples
    • unstained sections from selected regions
  • Plasma from blood samples obtained from living subjects and controls
  • DNA extracted from leukocytes of blood samples from living individuals
  • Postmortem CSF is available in some cases.

Pathologic diagnoses of postmortem cases available in brain bank:

  • No pathologic diagnosis (non-demented control)
  • Alzheimer disease
  • Dementia with Lewy bodies
  • Frontotemporal lobar degeneration (FTLD)
    • FTLD with ubiquitin inclusions (FTLD with motor neuron disease-type inclusions, TDP-43 proteinopathy)
    • Pick disease
    • Corticobasal degeneration
    • Tauopathy, sporadic unclassifiable
    • Tauopathy, familial (FTDP-17)
    • Progressive supranuclear palsy
    • Tangle-predominant senile dementia
  • Amyotrophic lateral sclerosis / motor neuron disease
  • Vascular dementia
The Northwestern Alzheimer's Disease Center (NADC) maintains a registry of research participants for whom we have clinical data and tissue samples. The research participants include individuals over age 50 with no cognitive impairment, individuals with mild cognitive impairment and no dementia, and individuals with dementia (Alzheimer's disease and non-AD forms including frontotemporal dementia, primary progressive aphasia, and dementia with Lewy bodies. The clinical data consist of demographic information, including health and family history, and neuropsychological test scores. Subjects are tested annually and some have been followed for up to 8 years. The tissue samples include blood and extracted DNA, and some participants who have expired have donated their brains for scientific study.
Other Name(s): Northwestern Neuropathology Core of CNADC, Northwestern's Cognitive Neurology and Alzheimers Disease Center Tissue/Neuropathology Core, Northwestern University Cognitive Neurology and Alzheimers Disease Center Tissue/Neuropathology Core, Northwestern University CNADC Tissue/Neuropathology Core, Northwestern University CNADC Tissue / Neuropathology Core, Northwestern Cognitive Neurology and Alzheimer's Disease Center Tissue/Neuropathology Core, Northwestern Cognitive Neurology Alzheimer's Disease Center Tissue/Neuropathology Core, Northwestern CNADC Tissue / Neuropathology Core
Parent Organization: Resource:Northwestern University Cognitive Neurology and Alzheimers Disease Center
Supporting Agency: NIA
Related to: Resource:One Mind Biospecimen Bank Listing, US Biobank
Resource Type(s): Brain bank, Material storage repository, Biomaterial supply resource, Data or information resource
Keywords: Brain tissue, Brain, Tissue, Plasma, Blood, DNA, Cerebral Spinal Fluid, Paraformaldehyde-fixed, Frozen, Paraffin block, Unfixed, Aging, Late adult human, Autopsy, Post-mortem, Clinical dementia rating scale, Mini mental state examination, Neuropathology, Clinical data, Alzheimer's disease, Dementia, Normal control, Non-demented control, Dementia with Lewy body, Frontotemporal lobar degeneration, Pick disease, Corticobasal degeneration, Tauopathy, Progressive Supranuclear Palsy, Tangle-predominant senile dementia, Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Vascular dementia, Mild cognitive impairment
Grant: P30 AG13854
Abbreviation: Northwestern Tissue/Neuropathology Core, Northwestern Tissue / Neuropathology Core
Resource: Resource
URL: http://www.brain.northwestern.edu/research/for-researchers/index.html
Related condition/disease: Alzheimer's disease, Dementia, Normal control, Non-demented control, Dementia with Lewy body, Frontotemporal lobar degeneration, Pick disease, Corticobasal degeneration, Tauopathy, Progressive Supranuclear Palsy, Tangle-predominant senile dementia, Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Vascular dementia, Mild cognitive impairment
Processing: Paraformaldehyde-fixed, Frozen, Paraffin block, Unfixed
Address: Cognitive Neurology and Alzheimer's Disease Center (CNADC), Northwestern University, Feinberg School of Medicine, 320 E Superior, Searle 11-453, Chicago, IL 60611-3008 Telephone: 312-908-9339 Fax: 312-908-8789
Id: nlx_144054
Organism: Human
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Curated

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Notes

This page uses this default form:Resource

Old URL: http://www.brain.northwestern.edu/mdad/neuropathology.html

Contributors

Aarnaud, Akash



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Facts about Resource:Northwestern CNADC Tissue Bank / Neuropathology CoreRDF feed
AbbrevNorthwestern Tissue/Neuropathology Core, Northwestern Tissue / Neuropathology Core  +
AddressCognitive Neurology and Alzheimer's Disease Center (CNADC)  +, Northwestern University  +, Feinberg School of Medicine  +, 320 E Superior  +, Searle 11-453  +, Chicago  +, and IL 60611-3008 Telephone: 312-908-9339 Fax: 312-908-8789  +
CommentSample type: Brain tissue, Brain, Tissue, Plasma, Blood, DNA, Cerebral Spinal Fluid,
CurationStatuscurated  +
DefiningCitationhttp://www.brain.northwestern.edu/research/for-researchers/index.html  +
DefinitionCollect, catalog, and store, postmortem br Collect, catalog, and store, postmortem brain tissue and other samples from demented subjects and non-demented control individuals; to distribute postmortem brain tissue and other samples to investigators for use in research; and to provide qualitative and quantitative diagnostic information to physicians, families, and researchers.

The CNADC Tissue Bank has many types of specimens available for investigators. In most cases, available tissue includes:

  • Brain Tissue
    • paraformaldehyde-fixed wet tissue
    • paraffin blocks of paraformaldehyde-fixed brain
    • frozen unfixed brain samples
    • unstained sections from selected regions
  • Plasma from blood samples obtained from living subjects and controls
  • DNA extracted from leukocytes of blood samples from living individuals
  • Postmortem CSF is available in some cases.

Pathologic diagnoses of postmortem cases available in brain bank:

  • No pathologic diagnosis (non-demented control)
  • Alzheimer disease
  • Dementia with Lewy bodies
  • Frontotemporal lobar degeneration (FTLD)
    • FTLD with ubiquitin inclusions (FTLD with motor neuron disease-type inclusions, TDP-43 proteinopathy)
    • Pick disease
    • Corticobasal degeneration
    • Tauopathy, sporadic unclassifiable
    • Tauopathy, familial (FTDP-17)
    • Progressive supranuclear palsy
    • Tangle-predominant senile dementia
  • Amyotrophic lateral sclerosis / motor neuron disease
  • Vascular dementia
The Northwestern Alzheimer's Disease Center (NADC) maintains a registry of research participants for whom we have clinical data and tissue samples. The research participants include individuals over age 50 with no cognitive impairment, individuals with mild cognitive impairment and no dementia, and individuals with dementia (Alzheimer's disease and non-AD forms including frontotemporal dementia, primary progressive aphasia, and dementia with Lewy bodies. The clinical data consist of demographic information, including health and family history, and neuropsychological test scores. Subjects are tested annually and some have been followed for up to 8 years. The tissue samples include blood and extracted DNA, and some participants who have expired have donated their brains for scientific study.
donated their brains for scientific study.
ExampleImageNorthwestern Tissue-Neuropathology Core.PNG  +
GrantCategory:P30 AG13854   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleBrain bank  +, Material storage repository  +, Biomaterial supply resource  +, and Data or information resource  +
Idnlx_144054  +
Is part ofResource:Northwestern University Cognitive Neurology and Alzheimers Disease Center  +
KeywordsBrain tissue  +, Brain  +, Tissue  +, Plasma  +, Blood  +, DNA  +, Cerebral Spinal Fluid  +, Paraformaldehyde-fixed  +, Frozen  +, Paraffin block  +, Unfixed  +, Aging  +, Late adult human  +, Autopsy  +, Post-mortem  +, Clinical dementia rating scale  +, Mini mental state examination  +, Neuropathology  +, Clinical data  +, Alzheimer's disease  +, Dementia  +, Normal control  +, Non-demented control  +, Dementia with Lewy body  +, Frontotemporal lobar degeneration  +, Pick disease  +, Corticobasal degeneration  +, Tauopathy  +, Progressive Supranuclear Palsy  +, Tangle-predominant senile dementia  +, Amyotrophic Lateral Sclerosis  +, Motor Neuron Disease  +, Vascular dementia  +, and Mild cognitive impairment  +
LabelResource:Northwestern CNADC Tissue Bank / Neuropathology Core  +
ModifiedDate1 July 2013  +
Page has default formThis property is a special property in this wiki.Resource  +
ProcessingParaformaldehyde-fixed  +, Frozen  +, Paraffin block  +, and Unfixed  +
RelatedToResource:One Mind Biospecimen Bank Listing  +, and US Biobank  +
Related diseaseAlzheimer's disease  +, Dementia  +, Normal control  +, Non-demented control  +, Dementia with Lewy body  +, Frontotemporal lobar degeneration  +, Pick disease  +, Corticobasal degeneration  +, Tauopathy  +, Progressive Supranuclear Palsy  +, Tangle-predominant senile dementia  +, Amyotrophic Lateral Sclerosis  +, Motor Neuron Disease  +, Vascular dementia  +, and Mild cognitive impairment  +
SpeciesHuman  +
SuperCategoryResource  +
Supporting AgencyNIA  +
SynonymNorthwestern Neuropathology Core of CNADC  +, Northwestern's Cognitive Neurology and Alzheimers Disease Center Tissue/Neuropathology Core  +, Northwestern University Cognitive Neurology and Alzheimers Disease Center Tissue/Neuropathology Core  +, Northwestern University CNADC Tissue/Neuropathology Core  +, Northwestern University CNADC Tissue / Neuropathology Core  +, Northwestern Cognitive Neurology and Alzheimer's Disease Center Tissue/Neuropathology Core  +, Northwestern Cognitive Neurology Alzheimer's Disease Center Tissue/Neuropathology Core  +, and Northwestern CNADC Tissue / Neuropathology Core  +