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Resource:Retina Project

Name: Resource:Retina Project
Description: Images from cell type-specific protein expression in the retina using BAC transgenic mice from the GENSAT project. They carried out a screen for cell type-specific green fluorescent protein expression in the retina using BAC transgenic mice from the GENSAT project. Among others, mouse lines were identified in which the inhibitory cell types of the night vision and directional selective circuit were selectively labeled. They quantified the stratification patterns to predict potential synaptic connectivity between marked cells of different lines and found that some of the lines enabled targeted recordings and imaging of cell types from developing or mature retinal circuits. The results suggest the potential use of a stratification-based screening approach for characterizing neuronal circuitry in other layered brain structures, such as the neocortex.
[1]
Other Name(s): The Retina Project, GENSAT - Retina Project, GENSAT Retina Project, Retina Project from GENSAT, The Retina Project from GENSAT
Abbreviation: Retina Project
Parent Organization: Resource:GENSAT - Gene Expression Nervous System Atlas
Supporting Agency: Resource:Friedrich Miescher Institute, US Office of Naval Research, (Naval International Cooperative Opportunities in Science and Technology Program), Marie Curie Excellence, National Center for Competence in Research in Genetics, European Union, NINDS
Grant: HEALTH-F2-223156, contract N01NS02331, contract HHSN271200723701C
Resource Type(s): Spatially referenced dataset
Resource: Resource
URL: http://www.gensat.org/retina.jsp
*Id: nif-0000-25587
PMID: PMID 19648912
Related to: Resource:NIF Data Federation
Availability: Public, Acknowledgement requested
Keywords: electrophysiology, protein expression, fluorescent, gene, amacrine cell, astrocyte, bipolar cell, blood vessel, brain, cell, ganglion cell layer, central nervous system, circuit, horizontal cell, hybridization, microglia, adult mouse, muller cell, neocortex, neuronal, photoreceptor, protein, recombinase, retina, spinal cord, Mutant mouse strain, BAC, retinal cell, cell type, night vision, direction, neuronal circuitry, connectivity, Image collection
Organism: Mouse
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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References

  1. Siegert S et al. (2009) Genetic address book for retinal cell types. Nat Neurosci 12: 1197-204 PubMed

Notes

This page uses this default form:Resource

Contributors

Aarnaud, Ccdbuser, Yazin



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:Retina ProjectRDF feed
AbbrevRetina Project  +
AvailabilityPublic  +, and Acknowledgement requested  +
CurationStatuscurated  +
DefiningCitationhttp://www.gensat.org/retina.jsp  +
DefinitionImages from cell type-specific protein exp Images from cell type-specific protein expression in the retina using BAC transgenic mice from the GENSAT project. They carried out a screen for cell type-specific green fluorescent protein expression in the retina using BAC transgenic mice from the GENSAT project. Among others, mouse lines were identified in which the inhibitory cell types of the night vision and directional selective circuit were selectively labeled. They quantified the stratification patterns to predict potential synaptic connectivity between marked cells of different lines and found that some of the lines enabled targeted recordings and imaging of cell types from developing or mature retinal circuits. The results suggest the potential use of a stratification-based screening approach for characterizing neuronal circuitry in other layered brain structures, such as the neocortex.
n structures, such as the neocortex.
ExampleImageGensatretina.png  +
GrantCategory:HEALTH-F2-223156   +, Category:contract N01NS02331   +, and Category:contract HHSN271200723701C   +
Has default formThis property is a special property in this wiki.Resource  +
Has roleSpatially referenced dataset  +
Idnif-0000-25587  +
Is part ofResource:GENSAT - Gene Expression Nervous System Atlas  +
KeywordsElectrophysiology  +, Protein expression  +, Fluorescent  +, Gene  +, Amacrine cell  +, Astrocyte  +, Bipolar cell  +, Blood vessel  +, Brain  +, Cell  +, Ganglion cell layer  +, Central nervous system  +, Circuit  +, Horizontal cell  +, Hybridization  +, Microglia  +, Adult mouse  +, Muller cell  +, Neocortex  +, Neuronal  +, Photoreceptor  +, Protein  +, Recombinase  +, Retina  +, Spinal cord  +, Mutant mouse strain  +, BAC  +, Retinal cell  +, Cell type  +, Night vision  +, Direction  +, Neuronal circuitry  +, Connectivity  +, and Image collection  +
LabelResource:Retina Project  +
ModifiedDate6 March 2014  +
PMID19648912  +
Page has default formThis property is a special property in this wiki.Resource  +
RelatedToResource:NIF Data Federation  +
SpeciesMouse  +
SuperCategoryResource  +
Supporting AgencyResource:Friedrich Miescher Institute  +, US Office of Naval Research  +, (Naval International Cooperative Opportunities in Science and Technology Program)  +, Marie Curie Excellence  +, National Center for Competence in Research in Genetics  +, European Union  +, and NINDS  +
SynonymThe Retina Project  +, GENSAT - Retina Project  +, GENSAT Retina Project  +, Retina Project from GENSAT  +, and The Retina Project from GENSAT  +