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Resource:StRAnGER
| Name: | Resource:StRAnGER |
| Description: | StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER's algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context.
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| Other Name(s): | Statistical Ranking of ANotated Genomic Experimental Results |
| Parent Organization: | Resource:National Hellenic Research Foundation |
| Related to: | Resource:Gene Ontology Tools, Resource:GO |
| Resource Type(s): | Data analysis software |
| Keywords: | controlled vocabulary, functional analysis, genomics, Annotation, visualization, statistical analysis, term enrichment, ontology or annotation visualization |
| Abbreviation: | StRAnGER |
| Resource: | Resource |
| URL: | http://www.grissom.gr/stranger/ |
| PMID: | PMID 21293737 |
| Publication link: | http://www.ncbi.nlm.nih.gov/pubmed/21293737 |
| Availability: | Free for academic use |
| Address: | Metabolic Engineering and Bioinformatics Group, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou ave., 11635, Athens GREECE |
| Id: | nlx_25932 |
| Link to OWL / RDF: | Download this content as OWL/RDF |
Curation status: Curated
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| Abbrev | StRAnGER + |
| Address | Metabolic Engineering and Bioinformatics Group +, Institute of Biological Research and Biotechnology +, 48 Vassileos Constantinou ave. +, 11635 +, and Athens GREECE + |
| Availability | Free for academic use + |
| Comment | GO data updates: monthly (or more frequently) |
| CurationStatus | curated + |
| DefiningCitation | http://www.grissom.gr/stranger/ + |
| Definition | StRAnGER (Statistical Ranking of ANotated … StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER's algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context.
Platform: Online tool |
| ExampleImage |  + |
| Has default formThis property is a special property in this wiki. | Resource + |
| Has role | Data analysis software + |
| Id | nlx_25932 + |
| Is part of | Resource:National Hellenic Research Foundation + |
| Keywords | Controlled vocabulary +, Functional analysis +, Genomics +, Annotation +, Visualization +, Statistical analysis +, Term enrichment +, and Ontology or annotation visualization + |
| Label | Resource:StRAnGER + |
| ModifiedDate | 10 July 2012 + |
| PMID | 21293737 + |
| Page has default formThis property is a special property in this wiki. | Resource + |
| PublicationLink | http://www.ncbi.nlm.nih.gov/pubmed/21293737 + |
| RelatedTo | Resource:Gene Ontology Tools +, and Resource:GO + |
| SuperCategory | Resource + |
| Synonym | Statistical Ranking of ANotated Genomic Experimental Results + |
