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Resource:StRAnGER

Name: Resource:StRAnGER
Description: StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER's algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context.


Platform: Online tool
Other Name(s): Statistical Ranking of ANotated Genomic Experimental Results
Abbreviation: StRAnGER
Parent Organization: Resource:National Hellenic Research Foundation
Resource Type(s): Data analysis software
Resource: Resource
URL: http://www.grissom.gr/stranger/
*Id: nlx_25932
PMID: PMID 21293737
Publication link: http://www.ncbi.nlm.nih.gov/pubmed/21293737
Related to: Resource:Gene Ontology Tools, Resource:GO
Availability: Free for academic use
Address: Metabolic Engineering and Bioinformatics Group, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou ave., 11635, Athens GREECE
Keywords: controlled vocabulary, functional analysis, genomics, Annotation, visualization, statistical analysis, term enrichment, ontology or annotation visualization
Link to OWL / RDF: Download this content as OWL/RDF

Curation status: Uncurated

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Notes

This page uses this default form:Resource

Contributors

Aarnaud, Ccdbuser, Jcachat, Yazin



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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.

Facts about Resource:StRAnGERRDF feed
AbbrevStRAnGER  +
AddressMetabolic Engineering and Bioinformatics Group  +, Institute of Biological Research and Biotechnology  +, 48 Vassileos Constantinou ave.  +, 11635  +, and Athens GREECE  +
AvailabilityFree for academic use  +
CommentGO data updates: monthly (or more frequently)
CurationStatuscurated  +
DefiningCitationhttp://www.grissom.gr/stranger/  +
DefinitionStRAnGER (Statistical Ranking of ANotated StRAnGER (Statistical Ranking of ANotated Genomic Experimental Results) is a web application for the automated statistical analysis of annotated gene profiling experiments, exploiting controlled biological vocabularies, like the Gene Ontology or the KEGG pathways terms. Starting from annotated lists of differentially expressed genes StRAnGER repartitions and reorders the initial distribution of terms to define a new distribution of elements where each element pools terms holding the same enrichment score. The elements are then prioritized according to StRAnGER's algorithm and, by applying bootstrapping techniques, a corrected measure of the statistical significance of these elements is derived, enabling the selection of terms mapped to these elements, unambiguously associated with respective significant gene sets. Besides their high statistical score, another selection criterion for the terms is the number of their members, something that incurs a biological prioritization in line with a Systems Biology context.


Platform: Online tool logy context.

Platform: Online tool
ExampleImageStRAnGER.PNG  +
Has default formThis property is a special property in this wiki.Resource  +
Has roleData analysis software  +
Idnlx_25932  +
Is part ofResource:National Hellenic Research Foundation  +
KeywordsControlled vocabulary  +, Functional analysis  +, Genomics  +, Annotation  +, Visualization  +, Statistical analysis  +, Term enrichment  +, and Ontology or annotation visualization  +
LabelResource:StRAnGER  +
ModifiedDate10 July 2012  +
PMID21293737  +
Page has default formThis property is a special property in this wiki.Resource  +
PublicationLinkhttp://www.ncbi.nlm.nih.gov/pubmed/21293737  +
RelatedToResource:Gene Ontology Tools  +, and Resource:GO  +
SuperCategoryResource  +
SynonymStatistical Ranking of ANotated Genomic Experimental Results  +