arrow

From NeuroLex

Jump to: navigation, search



Subventricular Zone

Name: Subventricular Zone
Description: The subventricular zone (SVZ) is one of two sources of adult-born neurons in the mammalian brain, the other being the subgranular zone (SGZ) of the hippocampus. In most adult mammals, the SVZ is a three-layered sheath that lies along the lateral wall of the lateral ventricle and consists of type A, B, and C cells. Type A rest along the ventricle wall and are neuronal precursor cells, Type B are adjacent astrocytes, and Type C are immature precursors to the Type A neuroblasts. The neuronal precursor cells travel along the rostral migratory stream ensheathed in a tube of Type B astrocytes, until they reach the olfactory bulb. There they integrate into the existing cellular network and mature into local interneurons. While the majority become adult-born granule cells, a subset become periglomerular cells. Interestingly, the human SVZ differs from other mammals' in several ways. It consists of four layers rather than three: ependymal cells (layer I), a hypo cellular gap (layer II), a ribbon of astrocytes (layer III), and a transitional zone (layer IV). The astrocytes are capable of differentiating into many kinds of tissue including new neurons. However, there is no evidence that the proliferating neurons travel along the rostral migratory stream in a chain to populate the olfactory bulb with new interneurons, as is the case for other mammals.[1]
Synonym(s): subependymal zone[2]
Abbreviation: SVZ[3]
Is part of: Telencephalon
Has role: adult neurogenesis[4]
Super-category: Regional part of brain[5]
Id: nlx_144262
PMID: PMID 14973487
Publication link: http://www.nature.com/nature/journal/v427/n6976/full/nature02301.html
Related to: olfactory bulb (main) periglomerular cell, olfactory bulb (main) adult-born granule cell, olfactory bulb, rostral migratory stream[6]
Link to OWL / RDF: Download this content as OWL/RDF


References

  1. Doetsch F et al. (1997) Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17: 5046-61 PubMed
  2. Zafar RS et al. (1992) Localization of two binding domains for thrombospondin within fibronectin. Arch Biochem Biophys 297: 271-6 PubMed
  3. Alvarez-Buylla A & Garcia-Verdugo JM (2002) Neurogenesis in adult subventricular zone. J Neurosci 22: 629-34 PubMed
  4. Quiñones-Hinojosa A et al. (2006) Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells. J Comp Neurol 494: 415-34 PubMed
  5. Doetsch F et al. (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97: 703-16 PubMed
  6. Quiñones-Hinojosa A & Chaichana K (2007) The human subventricular zone: a source of new cells and a potential source of brain tumors. Exp Neurol 205: 313-24 PubMed

Contributors

Beez, Memartone



bookmark
Facts about Subventricular ZoneRDF feed
AbbrevSVZ  +
CurationStatusuncurated  +
DefinitionThe subventricular zone (SVZ) is one of tw The subventricular zone (SVZ) is one of two sources of adult-born neurons in the mammalian brain, the other being the subgranular zone (SGZ) of the hippocampus. In most adult mammals, the SVZ is a three-layered sheath that lies along the lateral wall of the lateral ventricle and consists of type A, B, and C cells. Type A rest along the ventricle wall and are neuronal precursor cells, Type B are adjacent astrocytes, and Type C are immature precursors to the Type A neuroblasts. The neuronal precursor cells travel along the rostral migratory stream ensheathed in a tube of Type B astrocytes, until they reach the olfactory bulb. There they integrate into the existing cellular network and mature into local interneurons. While the majority become adult-born granule cells, a subset become periglomerular cells. Interestingly, the human SVZ differs from other mammals' in several ways. It consists of four layers rather than three: ependymal cells (layer I), a hypo cellular gap (layer II), a ribbon of astrocytes (layer III), and a transitional zone (layer IV). The astrocytes are capable of differentiating into many kinds of tissue including new neurons. However, there is no evidence that the proliferating neurons travel along the rostral migratory stream in a chain to populate the olfactory bulb with new interneurons, as is the case for other mammals. neurons, as is the case for other mammals.
Has default formThis property is a special property in this wiki.PONS brain region  +
Has roleAdult neurogenesis  +
Idnlx_144262  +
Is part ofTelencephalon  +
LabelSubventricular Zone  +
ModifiedDate21 March 2012  +
PMID14973487  +
PublicationLinkhttp://www.nature.com/nature/journal/v427/n6976/full/nature02301.html  +
RelatedToOlfactory bulb (main) periglomerular cell  +, Olfactory bulb (main) adult-born granule cell  +, Olfactory bulb  +, and Rostral migratory stream  +
SuperCategoryRegional part of brain  +
Synonymsubependymal zone  +