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Tacrine

Name: Tacrine
Description: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. (PubChem) Pharmacology: Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process. Mechanism of action: Tacrine acts by elevating acetylcholine concentrations in the cerebral cortex by slowing the degradation of acetylcholine released by still intact cholinergic neurons. It does so by reversibly binding acetylcholinesterase. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Nootropic Agents. Parasympathomimetics
Synonym(s): THA, Tetrahydroaminacrine, Tetrahydroaminoacridine, Tetrahydroaminocrin, Tetrahydroaminocrine, Cognex, Romotal
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00382
*Id: CHEBI:45980
Related to: Acetylcholinesterase
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Contributors

Bandrow, Ccdbuser, Nifbot2, Whetzel



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Facts about TacrineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00382  +
DefinitionA cholinesterase inhibitor that crosses th A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. (PubChem) Pharmacology: Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process. Mechanism of action: Tacrine acts by elevating acetylcholine concentrations in the cerebral cortex by slowing the degradation of acetylcholine released by still intact cholinergic neurons. It does so by reversibly binding acetylcholinesterase. Drug type: Approved. Small Molecule. Drug category: Cholinesterase Inhibitors. Nootropic Agents. Parasympathomimetics rs. Nootropic Agents. Parasympathomimetics
Has roleDrug  +
IdCHEBI:45980  +
LabelTacrine  +
ModifiedDate31 July 2014  +
RelatedToAcetylcholinesterase  +
SuperCategoryMolecular entity  +
SynonymTHA  +, Tetrahydroaminacrine  +, Tetrahydroaminoacridine  +, Tetrahydroaminocrin  +, Tetrahydroaminocrine  +, Cognex  +, and Romotal  +