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Triflupromazine

Name: Triflupromazine
Description: A phenothiazine used as an antipsychotic agent and as an antiemetic. (PubChem) Pharmacology: Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system. Mechanism of action: Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). Drug type: Approved. Small Molecule. Drug category: Antiemetics. Antipsychotic Agents. Antipsychotics. Dopamine Antagonists
Synonym(s): Adazine, Fluopromazine, Psyquil, Siquil, Trifluopromazine
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00508
Id: CHEBI:9711
Related to: Cholinergic system, D(1A) dopamine receptor, Muscarinic acetylcholine receptor M1, 5-hydroxytryptamine 2B receptor, Muscarinic acetylcholine receptor M2, D(2) dopamine receptor
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Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00508  +
DefinitionA phenothiazine used as an antipsychotic a A phenothiazine used as an antipsychotic agent and as an antiemetic. (PubChem) Pharmacology: Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system. Mechanism of action: Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). Drug type: Approved. Small Molecule. Drug category: Antiemetics. Antipsychotic Agents. Antipsychotics. Dopamine Antagonists ents. Antipsychotics. Dopamine Antagonists
Has roleDrug  +
IdCHEBI:9711  +
LabelTriflupromazine  +
ModifiedDate31 July 2014  +
RelatedToCholinergic system  +, D(1A) dopamine receptor  +, Muscarinic acetylcholine receptor M1  +, 5-hydroxytryptamine 2B receptor  +, Muscarinic acetylcholine receptor M2  +, and D(2) dopamine receptor  +
SuperCategoryMolecular entity  +
SynonymAdazine  +, Fluopromazine  +, Psyquil  +, Siquil  +, and Trifluopromazine  +