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Venlafaxine

Name: Venlafaxine
Description: Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. (Wikipedia) Pharmacology: Venlafaxine, an antidepressant agent structurally unrelated to other antidepressants, is used to treat melancholia, generalized anxiety disorder (GAD), panic disorder, post-traumatic stress disorder, and hot flashes in breast cancer survivors. Mechanism of action: Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors. Drug type: Approved. Small Molecule. Drug category: Analgesics. Antidepressants. Antidepressive Agents, Second-Generation. Serotonin Uptake Inhibitors
Synonym(s): Venlafaxina (INN-Spanish), Venlafaxine (INN:Ban), Venlafaxinum (INN-Latin), Effexor, Effexor XR, Elafax
Related to: 5-hydroxytryptamine 1A receptor, 5-hydroxytryptamine 2A receptor, Sodium-dependent noradrenaline transporter, Sodium-dependent serotonin transporter, 5-hydroxytryptamine 1B receptor
Has role: Drug
Super-category: Molecular entity
URL: http://www.drugbank.ca/drugs/DB00285
Id: CHEBI: 9943
Link to OWL / RDF: Download this content as OWL/RDF


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Facts about VenlafaxineRDF feed
Commenttaken from DrugBank
CurationStatusuncurated  +
CuratorAb  +
DefiningCitationhttp://www.drugbank.ca/drugs/DB00285  +
DefinitionVenlafaxine (Effexor) is an antidepressant Venlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. (Wikipedia) Pharmacology: Venlafaxine, an antidepressant agent structurally unrelated to other antidepressants, is used to treat melancholia, generalized anxiety disorder (GAD), panic disorder, post-traumatic stress disorder, and hot flashes in breast cancer survivors. Mechanism of action: Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors. Drug type: Approved. Small Molecule. Drug category: Analgesics. Antidepressants. Antidepressive Agents, Second-Generation. Serotonin Uptake Inhibitors nd-Generation. Serotonin Uptake Inhibitors
Has roleDrug  +
IdCHEBI: 9943  +
LabelVenlafaxine  +
ModifiedDate14 April 2014  +
RelatedTo5-hydroxytryptamine 1A receptor  +, 5-hydroxytryptamine 2A receptor  +, Sodium-dependent noradrenaline transporter  +, Sodium-dependent serotonin transporter  +, and 5-hydroxytryptamine 1B receptor  +
SuperCategoryMolecular entity  +
SynonymVenlafaxina (INN-Spanish)  +, Venlafaxine (INN:Ban)  +, Venlafaxinum (INN-Latin)  +, Effexor  +, Effexor XR  +, and Elafax  +