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129 +Inbr and colour depends on substrain (see Inbr and colour depends on substrain (see below). Origin: Dunn 1928 from crosses of coat colour stocks from English fanciers and a chinchilla stock from Castle. This strain has a common origin with strain 101. Most substrains carry the white-bellied agouti gene AW though only a subset have the agouti pattern as many carry albino or chinchilla and/or the pink-eyed dilution gene, p, which is derived from Asian mice of the Mus musculus type (see also strains SJL, P/J and FS/Ei) (Brilliant et al, 1994). It is known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains, but more recently it has been the most widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells. Two recent studies show that there is major genetic variation within the 129 "family", at least some of which must be attributed to genetic contamination (Threadgill et al, 1997,Simpson et al, 1997). Strain 129/SvJ was genetically contaminated in about 1978 by an unknown strain, and differs from other 129 substrains at about 25% of SSLP genetic markers. Threadgill et al suggest that it is equivalent to a recombinant congenic strain and suggest that it is designated 129cX/Sv. Simpson et al recognised three major groups of substrains: parental substrains, steel substrains and "ter" substrains. Threadgill et al identified substrains 129/Ola, 129/J, 129/Sv, 129/ReJ and 129/RrRk, and the associated embryonic stem cells. Clearly, major revision of the nomenclature of this group of strains is necessary. This will be undertaken in the next revision. In the mean time, people doing targeted mutagenesis should take special care to ensure that the genotype of their embryonic stem cell culture matches the substrain of mice which they use. ches the substrain of mice which they use.
129P1/ReJ +Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Generation: F155 (18-OCT-06) Appearance pink-eyed, light-bellied chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc-ch Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset between 3 and 5 months of age. Strain Description For a complete history of the numerous 129 substrains please refer to Simpson, et al., 1997. Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. Most recently 129 mice are widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of substrains into three major groups: parental substrains, steel substrains and "ter" substrains. Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. ain to match the embryonic stem cell line.
129P3/J +Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: bc (see, Fischer Lindahl K 1997) Generation: F175 (14-DEC-06) Appearance: pink-eyed, light-bellied, light chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc or albino Related Genotype: Aw/Aw p Tyrc/p Tyrc Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset prior to 3 months of age. Strain Description Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997. 129 substrains, see Simpson, et al., 1997.
129P3/JEmsJ +Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Appearance pink-eyed, light-bellied chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc-ch
129P4/RrRkJ +Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Appearance pink-eyed, light-bellied, light chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc OR albino Related Genotype: Aw/Aw p Tyrc/p Tyrc Strain Description For a complete history of the numerous 129 substrains please refer to Simpson, et al., 1997. Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. Most recently 129 mice are widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of substrains into three major groups: parental substrains, steel substrains and "ter" substrains. Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. ain to match the embryonic stem cell line.
129S1/SvImJ +Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Generation: F64 (14-DEC-06) Appearance white-bellied agouti Related Genotype: Aw/Aw Important Note This strain is homozygous for Gnat2cpfl3 cone photoreceptor function loss 3 which affects bright light (photopic) vision. Strain Description Historically the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas though the incidence differs between substrains.(1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 'family' which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P) steel substrains (129S) and 'teratoma' substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains see Simpson et al. 1997. In response to challenge 129S1/SvImJ mice develop immune-mediated nephritis characterized by proteinuria glomerulonephritis and tubulointerstitial disease (Xie et al. 2004). Strain Development 129S1/SvImJ was developed to serve as a control inbred strain for many of the steel-derived ES cell lines (e.g. W9.5 and CJ7). SSLP marker analysis indicates that 129S1/SvImJ is identical to 129S1/Sv +p +Tyr-c KitlSl-J/+ except for the region surrounding the Kitl gene on Chr 10. 129S1/SvImJ was derived from 129S1/Sv-+p +Tyr-c KitlSl-J/+ (Stock No. 000090). The steel-Jackson mutation (KitlSl-J formerly MgfSl-J) is segregating in Stock No. 000090. KitlSl-J was removed in 1995 at F26 by selective breeding to produce 129/Sv-+p +Tyr-c +Kitl-SlJ (Stock No. 002448 see Simpson et al. 1997). This name was later shortened to simply 129/SvImJ. Subsequently designated 129S3/SvImJ (Festing et al. 1999) this strain was renamed 129S1/SvImJ in February 2001 to emphasize its relationship to Stock No. 000090. size its relationship to Stock No. 000090.
129S6/SvEvTac +Model Description * Progenitors of thi Model Description * Progenitors of this strain used extensively to establish Embryonic Stem (ES) cell lines (e.g., W4) for the production of targeted mutation (knockout) mice * Targeted mutation mice developed from 129 agouti ES cell lines can often be maintained with maximum genomic homozygosity by mating chimeras to the 129S6 strain * Taconic's 129 mice are of the Steel ('S') subline. Origin Taconic received 129S6 inbred model stock from GenPharm International from two sublines originating from Dr. Martin Evan's colony in 1992. The mice were derived by embryo transfer in 1993. The resulting offspring were heterozygous at Gpi1 for the 'a' and 'c' alleles. Homozygous Gpi-1c brother x sister mice were selected in the Foundation Colony at F8 and became the common ancestors for all subsequent Taconic breeders. The Taconic foundation colony was at F42 in 2005. Color: White-bellied Black Agouti Coat Color Loci: Aw Genetics: * Strain Profile: Acy1s, Akp1b, Amy1a, Apoa1b, Car2a, Es1b, Es3c, Esdb, Es11a, Ggca, Glo1a, Got2b, Gpi1c, Gpt1a, Gr1a, Gus-sb, H6pdb, Hbbd, Idh1a, Ldr1a, Mod1a, Mpi1b, Neu1b, Pep3b, Pgm1b, Pgm2a, Pnpa, Trfb, Sod1a * Immunology: H2b * Other: Ptprc a * Immunology: H2b * Other: Ptprc
129T2/SvEms +Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Appearance light-bellied agouti chinchilla Related Genotype: Aw/Aw Tyrc-ch/Tyrc-ch
129T2/SvEmsJ +Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Appearance light-bellied agouti chinchilla Related Genotype: Aw/Aw Tyrc-ch/Tyrc-ch Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. Strain Description Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997. 129 substrains, see Simpson, et al., 1997.
129X1/SvJ +Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Generation: F119 (14-DEC-06) Appearance pink-eyed, light-bellied, light chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc OR albino Related Genotype: Aw/Aw p Tyrc/p Tyrc Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset prior to 3 months of age. Strain Description Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997. White et al. reported a variation in thioglycolate medium-induced peritoneal leukocyte recruitment in 4 analyzed strains. The response of total leukocyte recruitment, from greatest to least, was C57BL/6J>BALB/c>CD1>129X1/SvJ. Variations were also found in the timeline of response and cell types most impacted. of response and cell types most impacted.

A

A +Inbr: More than F150. Albino. Genet: a, b, Inbr: More than F150. Albino. Genet: a, b, c. Origin: Dr L. C. Strong, 1921, from a cross between the Cold Spring Harbor and Bagg albino random-bred stocks (and therefore relavted to BALB/c). Internationally distributed, Strain A was the third most widely used strain in cancer and immunology research (Festing, 1969), though its popularity has probably declined recently. Although it may be classified as a general-purpose strain, it is well known for a high susceptibility to induction of congenital cleft palate by cortisone and a high spontaneous incidence of lung adenomas, as well as developing a high incidence of lung tumours in response to carcinogens. Shimkin and Stoner (1975) suggest that this response may be used as a rapid in vivo assay for carcinogenesis. The strain also suffers from a defect in macrophage function somewhat resembling the mutant lps found in C3H/HeJ (Vogel et al 1981). t lps found in C3H/HeJ (Vogel et al 1981).
A/HeJ +Type: Inbred Strain TJL Mating System: Sib Type: Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: a Generation: F272 (14-DEC-06) Appearance albino Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Strain Description Developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino, the A inbred strain is used widely used in cancer and immunology research. It is highly susceptible to induction of congenital cleft palate by cortisone. It has a high incidence of spontaneous lung adenomas and lung tumors readily develop in response to carcinogens. High percentage of mammary adenocarcinomas (a large proportion acinar type) develop in multiparous females. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in The Jackson Laboratory substrains. A small percent (4%) of nonproductive males are hermaphrodites. An additional 17% of nonproductive males have abnormally small testes containing no sperm. normally small testes containing no sperm.
A/J +Type: Inbred Strain TJL Mating System: Sib Type: Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: a Generation: F275 (14-DEC-06) Appearance albino Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset between 3 and 5 months of age. Strain Description Developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino, the A inbred strain is used widely used in cancer and immunology research. It is highly susceptible to cortisone-induced congenital cleft palate by cortisone. It has a high incidence of spontaneous lung adenomas, and lung tumors readily develop in response to carcinogens. A high percentage of mammary adenocarcinomas (a large proportion acinar type) develop in multiparous females. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in The Jackson Laboratory substrains. A/J mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid, and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687). A/J mice develop cigarette smoke-induced emphysema in approximately half the time when compared with C57BL/6J mice. This inbred strain develops a late onset (4-5 months) progressive muscular dystrophy as a result of a retrotransposon insertion in the dysferlin (Dysf) gene. The Dysfprmd allele, carried by A/J mice, has been shown to result in degeneration and regeneration of myofibers and centrally placed nuclei. Proximal muscles are more severely affected than distal muscles (Ho M, et al. 2004). Sequencing of the mitochondrial genome of A/J revealed 10 adenines in a polymorphic adenine repeat sequence in the mt-Tr sequence. This repeat contains 9 adenines in NOD/LtJ, A/HeJ, A/WySnJ, and SKH2/J and 10 adenines in A/J, and NZB/B1NJ, and likely enhances the hearing loss associated w ith the ahl allele of Cdh23 (Johnson et al., 2001). hl allele of Cdh23 (Johnson et al., 2001).
A/WySnJ +Type: Inbred Strain TJL Mating System: Sib Type: Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: a Generation F257 (16-NOV-05) Appearance albino Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. Strain Description Developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino, the A inbred strain is used widely used in cancer and immunology research. It is highly susceptible to induction of congenital cleft palate by cortisone. It has a high incidence of spontaneous lung adenomas and lung tumors readily develop in response to carcinogens. High percentage of mammary adenocarcinomas (a large proportion acinar type) develop in multiparous females. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in The Jackson Laboratory substrains. Unlike A/J mice, A/WySnJ mice carry a spontaneous mutation in Tnfrsf13c and exhibit a significant loss of mature B cells (Miller, et al., 1991, Lentz et al., 1996, Shulga-Morskaya et al., 2004). al., 1996, Shulga-Morskaya et al., 2004).
Abducens nerve +The 6th cranial nerve. The abducens nerve originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye. Damage to the nerve or its nucleus disrupts horizontal eye movement control. (MSH)
Accessory nerve +The 11th cranial nerve. The accessory nerv The 11th cranial nerve. The accessory nerve originates from neurons in the medulla and in the cervical spinal cord. It has a cranial root, which joins the vagus (10th cranial) nerve and sends motor fibers to the muscles of the larynx, and a spinal root, which sends motor fibers to the trapezius and the sternocleidomastoid muscles. Damage to the nerve produces weakness in head rotation and shoulder elevation. s in head rotation and shoulder elevation.
Actinopterygii +* A group of cold-blooded, aquatic vertebr * A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales. (MSH) * A vertebrate animal usually having fins and a covering of scales or plates. It breathes by means of gills, and lives almost entirely in the water. (from Webster, 1913) (NCI) * any of numerous cold-blooded strictly aquatic craniate vertebrates that include the bony fishes and usually the cartilaginous and jawless fishes and that have typically an elongated somewhat spindle-shaped body terminating in a broad caudal fin, limbs in the form of fins when present at all, and a 2-chambered heart by which blood is sent through thoracic gills to be oxygenated. (CSP) ugh thoracic gills to be oxygenated. (CSP)
Adenohypophysis +* The anterior glandular lobe of the pitui * The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION. (MSH) * The glandular or anterior lobe of the pituitary gland which secretes several hormones. (NCI) and which secretes several hormones. (NCI)
Aldehyde +Organic compounds containing a carbonyl group in the form -CHO. (MSH)
Anger +A strong emotional feeling of displeasure aroused by being interfered with, injured or threatened (MeSH).
Annelida +* A phylum of metazoan invertebrates compr * A phylum of metazoan invertebrates comprising the segmented worms, and including marine annelids (POLYCHAETA), freshwater annelids, earthworms (OLIGOCHAETA), and LEECHES. Only the leeches are of medical interest. (Dorland, 27th ed) (MSH) * phylum of metazoan invertebrates comprising the segmented worms, and including marine annelids (Polychaeta), freshwater annelids, earthworms (Oligochaeta), and Leeches. (CSP) rthworms (Oligochaeta), and Leeches. (CSP)
Anterior commisure +A forebrain white matter structure consist A forebrain white matter structure consisting of a large fiber bundle, connecting the two cerebral hemispheres across the middle line, located in front of the columns of the fornix. On sagittal section it is oval in shape, its long diameter being vertical and measuring about 5 mm. Its fibers can be traced lateralward and backward on either side beneath the corpus striatum into the substance of the temporal lobe. It serves in this way to connect the two temporal lobes, but it also contains decussating fibers from the olfactory tracts. (http://en.wikipedia.org/wiki/Anterior_commissure) en.wikipedia.org/wiki/Anterior_commissure)
Anterior nucleus of hypothalamus +Loose heterogeneous collection of cells in the anterior hypothalamus, continuous rostrally with the medial and lateral preoptic areas and caudally with the tuber cinereum. (MSH)
Anxiety +Persistent feeling of dread, apprehension, and impending disaster (MeSH).
Aotus trivirgatus +A species of the subfamily AOTINAE, family A species of the subfamily AOTINAE, family CEBIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys. (MSH) lso known as Northern night monkeys. (MSH)
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