|
|
From NeuroLex
| Comment
|
taken from DrugBank
|
| CurationStatus
|
uncurated +
|
| Curator
|
Ab +
|
| DefiningCitation
|
http://www.drugbank.ca/drugs/DB00107 +
|
| Definition
|
Synthetic 9 residue cyclic peptide. The ho … Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity. Pharmacology: Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term. Mechanism of action: Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. Drug type: Approved. Biotech. Drug category: Anti-tocolytic Agents. Labor Induction Agents. Oxytocics Agents. Labor Induction Agents. Oxytocics
|
| Has role
|
Drug +,
Neuropeptide +
|
| Id
|
CHEBI_7872 +
|
| Label
|
Oxytocin +
|
| Modification dateThis property is a special property in this wiki.
|
9 November 2010 01:25:11 +
|
| ModifiedDate
|
9 November 2010 +
|
| RelatedTo
|
Oxytocin-neurophysin 1 +,
Prolyl endopeptidase +
|
| SuperCategory
|
Peptide +
|
| Synonym
|
Pitocin +,
Syntocinon +,
Oxytocin (BAM Biotech) +,
Pitocin (Parke-Davis) +,
Syntocinon (Sandoz) +
|
| Categories |
Peptide
|
|
|
