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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition Synthetic 9 residue cyclic peptide. The ho Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity. Pharmacology: Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term. Mechanism of action: Binds the oxytocin receptor which leads to an increase in intracellular calcium levels. Drug type: Approved. Biotech. Drug category: Anti-tocolytic Agents. Labor Induction Agents. Oxytocics Agents. Labor Induction Agents. Oxytocics
Has role Drug +, Neuropeptide +
Id CHEBI:7872  +
Label Oxytocin  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:23:14  +
ModifiedDate 12 August 2014  +
RelatedTo Oxytocin-neurophysin 1 +, Prolyl endopeptidase +
SuperCategory Peptide  +
Synonym Pitocin  +, Syntocinon  +, Oxytocin (BAM Biotech)  +, Pitocin (Parke-Davis)  +, Syntocinon (Sandoz)  +
Categories Peptide
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Hypothalamus oxytocin neuroendocrine magnocellular cell + Neurotransmitter


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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.