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Abbrev 129  +
AbbrevSource MGI  +
Created 15 August 2007  +
CurationStatus pending_final_vetting  +
DefiningCitation Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23  +
ExternallySourcedDefinition Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Appearance pink-eyed, light-bellied, light chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc OR albino Related Genotype: Aw/Aw p Tyrc/p Tyrc Strain Description For a complete history of the numerous 129 substrains please refer to Simpson, et al., 1997. Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. Most recently 129 mice are widely used strain in the production of targeted mutations due to the availability of several lines of embryonic stem cells. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of substrains into three major groups: parental substrains, steel substrains and "ter" substrains. Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. ain to match the embryonic stem cell line.
Id birnlex_109  +
Modification dateThis property is a special property in this wiki. 26 May 2009 12:39:50  +
Categories 129
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