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Model Description * Progenitors of thi … Model Description * Progenitors of this strain used extensively to establish Embryonic Stem (ES) cell lines (e.g., W4) for the production of targeted mutation (knockout) mice * Targeted mutation mice developed from 129 agouti ES cell lines can often be maintained with maximum genomic homozygosity by mating chimeras to the 129S6 strain * Taconic's 129 mice are of the Steel ('S') subline. Origin Taconic received 129S6 inbred model stock from GenPharm International from two sublines originating from Dr. Martin Evan's colony in 1992. The mice were derived by embryo transfer in 1993. The resulting offspring were heterozygous at Gpi1 for the 'a' and 'c' alleles. Homozygous Gpi-1c brother x sister mice were selected in the Foundation Colony at F8 and became the common ancestors for all subsequent Taconic breeders. The Taconic foundation colony was at F42 in 2005. Color: White-bellied Black Agouti Coat Color Loci: Aw Genetics: * Strain Profile: Acy1s, Akp1b, Amy1a, Apoa1b, Car2a, Es1b, Es3c, Esdb, Es11a, Ggca, Glo1a, Got2b, Gpi1c, Gpt1a, Gr1a, Gus-sb, H6pdb, Hbbd, Idh1a, Ldr1a, Mod1a, Mpi1b, Neu1b, Pep3b, Pgm1b, Pgm2a, Pnpa, Trfb, Sod1a * Immunology: H2b * Other: Ptprc a * Immunology: H2b * Other: Ptprc
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