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Category:129X1/SvJ
Abbrev 129  +
AbbrevSource MGI  +
Created 15 August 2007  +
CurationStatus pending_final_vetting  +
DefiningCitation Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23  +
ExternallySourcedDefinition Type: Inbred Strain Type: Segregating Inbr Type: Inbred Strain Type: Segregating Inbred TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: b Generation: F119 (14-DEC-06) Appearance pink-eyed, light-bellied, light chinchilla Related Genotype: Aw/Aw p Tyrc-ch/p Tyrc OR albino Related Genotype: Aw/Aw p Tyrc/p Tyrc Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset prior to 3 months of age. Strain Description Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997. White et al. reported a variation in thioglycolate medium-induced peritoneal leukocyte recruitment in 4 analyzed strains. The response of total leukocyte recruitment, from greatest to least, was C57BL/6J>BALB/c>CD1>129X1/SvJ. Variations were also found in the timeline of response and cell types most impacted. of response and cell types most impacted.
Id birnlex_557  +
Modification dateThis property is a special property in this wiki. 26 May 2009 12:39:38  +
Categories 129
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