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CommonName AHe  +, A Heston  +
Created 16 August 2007  +
CurationStatus pending_final_vetting  +
ExternallySourcedDefinition Type: Inbred Strain TJL Mating System: Sib Type: Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: a Generation: F272 (14-DEC-06) Appearance albino Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Strain Description Developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino, the A inbred strain is used widely used in cancer and immunology research. It is highly susceptible to induction of congenital cleft palate by cortisone. It has a high incidence of spontaneous lung adenomas and lung tumors readily develop in response to carcinogens. High percentage of mammary adenocarcinomas (a large proportion acinar type) develop in multiparous females. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in The Jackson Laboratory substrains. A small percent (4%) of nonproductive males are hermaphrodites. An additional 17% of nonproductive males have abnormally small testes containing no sperm. normally small testes containing no sperm.
Id birnlex_581  +
Modification dateThis property is a special property in this wiki. 26 May 2009 12:39:29  +
Categories A
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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.