| Authors
|
Zhiyin Xun +,
Rena A. Sowell +,
Thomas C. Kaufman +,
David E. Clemmer +
|
| CurationStatus
|
uncurated +
|
| Definition
|
These transgenic flies express human A30P … These transgenic flies express human A30P alpha-synuclein. The A30P mutation disrupts an alpha-helical structure in the N-terminal region of the wild type alpha-synuclein. This mutation accelerates alpha-synuclein oligomerization, decreases the rate of mature fibril formation, reduces cellular activity, and reduces cellular affinity for lipids. It has an early onset and a slightly faster aggregation than wild type alpha-synuclein. Drosophila displaying this mutation show symptoms of Parkinson's disease and are used in the laboratory to study this disorder. in the laboratory to study this disorder.
|
| Id
|
nlx_organ_090702 +
|
| JournalVolume
|
6 +
|
| Label
|
A30P Alpha-Synuclein Drosophila +
|
| Modification dateThis property is a special property in this wiki.
|
28 October 2009 01:10:43 +
|
| ModifiedDate
|
28 October 2009 +
|
| PMID
|
17683129 +
|
| Pages
|
3729-3738
|
| PublicationDate
|
08/07/07 +
|
| PublicationName
|
Journal Of Proteone Research +
|
| Title
|
Lifetime Proteomic Profiling of an A30P Alpha-Synuclein Drosophila Model of Parkinson's Disease +
|
| Categories |
Mutant Drosophila
|
