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Category:A30P Alpha-Synuclein Drosophila
Authors Zhiyin Xun  +, Rena A. Sowell  +, Thomas C. Kaufman  +, David E. Clemmer  +
CurationStatus uncurated  +
Definition These transgenic flies express human A30P These transgenic flies express human A30P alpha-synuclein. The A30P mutation disrupts an alpha-helical structure in the N-terminal region of the wild type alpha-synuclein. This mutation accelerates alpha-synuclein oligomerization, decreases the rate of mature fibril formation, reduces cellular activity, and reduces cellular affinity for lipids. It has an early onset and a slightly faster aggregation than wild type alpha-synuclein. Drosophila displaying this mutation show symptoms of Parkinson's disease and are used in the laboratory to study this disorder. in the laboratory to study this disorder.
Id nlx_organ_090702  +
JournalVolume 6 +
Label A30P Alpha-Synuclein Drosophila  +
Modification dateThis property is a special property in this wiki. 28 October 2009 01:10:43  +
ModifiedDate 28 October 2009  +
PMID 17683129  +
Pages 3729-3738
PublicationDate 08/07/07 +
PublicationName Journal Of Proteone Research +
Title Lifetime Proteomic Profiling of an A30P Alpha-Synuclein Drosophila Model of Parkinson's Disease  +
Categories Mutant Drosophila
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