arrow

From NeuroLex

Jump to: navigation, search
Category:A30P Alpha-Synuclein Drosophila
Authors Zhiyin Xun  +, Rena A. Sowell  +, Thomas C. Kaufman  +, David E. Clemmer  +
CurationStatus uncurated  +
Definition These transgenic flies express human A30P These transgenic flies express human A30P alpha-synuclein. The A30P mutation disrupts an alpha-helical structure in the N-terminal region of the wild type alpha-synuclein. This mutation accelerates alpha-synuclein oligomerization, decreases the rate of mature fibril formation, reduces cellular activity, and reduces cellular affinity for lipids. It has an early onset and a slightly faster aggregation than wild type alpha-synuclein. Drosophila displaying this mutation show symptoms of Parkinson's disease and are used in the laboratory to study this disorder. in the laboratory to study this disorder.
Id nlx_organ_090702  +
JournalVolume 6 +
Label A30P Alpha-Synuclein Drosophila  +
Modification dateThis property is a special property in this wiki. 28 October 2009 01:10:43  +
ModifiedDate 28 October 2009  +
PMID 17683129  +
Pages 3729-3738
PublicationDate 08/07/07 +
PublicationName Journal Of Proteone Research +
Title Lifetime Proteomic Profiling of an A30P Alpha-Synuclein Drosophila Model of Parkinson's Disease  +
Categories Mutant Drosophila
hide properties that link here 
  No properties link to this page.
 

 

Enter the name of the page to start browsing from.

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.