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From NeuroLex
| Authors
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Robert Bussel Jr. and David Eliezer +
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| CurationStatus
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uncurated +
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| Definition
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These mutant flies express a the human mut … These mutant flies express a the human mutant A53T alpha-synuclein mutation. This mutation alters the secondary shift of residue 53 from a positive to a negative value and thereby creates a short contiguous region of negative shifts around the site of the mutation, indicating a local preference for extended backbone configurations. This mutation accelerates alpha-synuclein oligomerization, increases the rate of mature fibril formations, and aggregates much faster than wild type alpha-synuclein. It has an earlier onset. Flies expressing A53T alpha-synuclein show symptoms of Parkinson's disease and are used in the lab to study the disease. are used in the lab to study the disease.
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| Figure
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1 +,
2 +,
3 +
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| Id
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nlx_organ_090703 +
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| JournalNumber
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49 +
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| JournalVolume
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276 +
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| Label
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A53T Alpha-Synuclein Drosophila +
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| Modification dateThis property is a special property in this wiki.
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28 October 2009 01:13:35 +
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| ModifiedDate
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28 October 2009 +
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| PMID
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11590151 +
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| Pages
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45996-46003
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| PublicationDate
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12/07/01 +
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| PublicationName
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The Journal of Biological Chemistry +
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| Title
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Residual Structure and Dynamics in Parkinson's Disease-associated Mutants of Alpha-Synuclein +
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| Categories |
Mutant Drosophila
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